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A new Cytotoxic Triterpene Hydroperoxide from the Aerial Part of Youngia japonica  

이강노 (성균관대학교 약학대학 천연물약품화학 연구실)
이원빈 (성균관대학교 약학대학 천연물약품화학 연구실)
권학철 (성균관대학교 약학대학 천연물약품화학 연구실)
이재훈 (성균관대학교 약학대학 천연물약품화학 연구실)
최상운 (한국화학연구소)
Publication Information
YAKHAK HOEJI / v.46, no.1, 2002 , pp. 1-5 More about this Journal
Abstract
A new cytotoxic triterpene hydroperoxide (3) was isolated from the methylene chloride extract of the aerial part of Youngia japonica together with four known triterpenes (1, 2, 4 and 5). Their structures were identified by means of physico-chemical and spectral data to be $\beta$-amyrin acetate (1), taraxasterol (2), 2l$\alpha$-hydroperoxy-taraxasterol (3), oleanolic acid (4) and ursolic acid (5). Compounds 3 and 5 showed moderate cytotoxicity against five tumor cell lines.
Keywords
Youngia japonica; compositae; triterpene; 21$\alpha$-hydroperoxy-taraxasterol; cytotoxicity;
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  • Reference
1 Mass spectrometry in structural and stereochemical problems XXXII /
[ Budzikiewicz ] / J. Am. Chem. Soc
2 Current aspects of practical two-dimensional(2D) nuclear magnetic resonance(NMR) spectroscopy : Application to structure elucidation /
[ Kriwacki, R. W.;Pitner, T. P. ] / Pharmaceutical Research   DOI   ScienceOn
3 A triterpene glycoside from the fruits of Tetrapleura tetraptera /
[ Maillard, M.;Adewunmi, C. O.;Hostettman, K. ] / Phytochemistry   DOI   ScienceOn
4 /
[ 송주택;정현배;김병우;진희성 ] / 식물대보감
5 Isolation of isoamberboin and isolipidiol from while plants of Youngia japonica(L.) DC. /
[ Jang, D. S.;Ha, T. J.;Choi, S. U.;Nam, S. H.;Park, K. H.;Yang, M. S. ] / Kor. J. Pharmacogn.
6 New colorimetric cytotoxicity assay for anticancer-drug screening /
[ Skehan, P.;Storeng, R.;Scudiero, D.;Monks, A.;McMahon, J.;Vistica, D.;Warren, J. T.;Bokesch, H.;Kenney, S.;Boyd, M. R. ] / J. Natl. Cancer Inst.   DOI
7 /
[ 배기환 ] / 한국의 약용식물
8 A new caffeoyl quinic acid from Aster scaber and Its Inhibitory Activity against Human Immunodeficiency Virus-1(HIV-1) Integrase /
[ Kwon, H. C.;Jung, C. M.;Shin, C. G.;Lee, J. K.;Choi, S. U.;Lee, K. R. ] / Chem. Pharm. Bull.
9 Artekeiskeanin A : A new coumarin-monoterpene ether from Artemisia keiskeana /
[ Kwak, J. H.;Jang, W. Y.;Zee, O. P.;Lee, K. R. ] / Planta Med
10 Cytotoxic triterpenes from a Chinese medicine, Goreishi /
[ Numata, A.;Yang, P.;Takahashi, C.;Fujiki, R.;Nabae, M.;Fujita, E. ] / Chem. Pharm. Bull.   DOI   ScienceOn
11 Triterpene constituents from Euphorbia supina /
[ Tanaka, R.;Matsunaga, S. ] / Phytochemistry   DOI   ScienceOn
12 Carbon-13 NMR spectra of urs-12-enes and application to structural assignment of components of Isodon japonicus HARA tissue cultures /
[ Seo, S.;Tomita, Y.;Tori, K. ] / Tetrahedron Lett
13 Studies on Sesquiterpene Glycosides from Crepis japonica BENTH. /
[ Miyase, T.;Ueno, A.;Noro, T.;Kuroyanagi. M.;Fukushima, S. ] / Chem. Pharm. Bull.   DOI
14 Structure elucidation by NMR in organic chemistry /
[ Breitmaier, E. ] / A practical guide
15 A taraxasterol derivative and phenolic compounds from Hieracium gymnocephalum /
[ Petrovic, S. D.;Gorunovic, M. S.;Wray, V.;Merfort, I. ] / Phytochemistry   DOI   ScienceOn
16 Peroxide constituents in the natural product research /
[ Lee, K. R. ] / Kor. J. Pharmacogn.
17 Triterpenoids from euphorbia maculata /
[ Matsunaga, S.;Tanak, R.;Akagi, M. ] / Phytochemistry   DOI   ScienceOn
18 /
[ 안덕균 ] / 한국본초도감
19 Triterpenoids from Mangifera indica /
[ Anjaneyulu, V.;Ravi, K.;Prasad, K. H.;Connolly, J. D. ] / Phytochemistry   DOI   ScienceOn
20 Triterpenoids of Akebia Quinata callus tissue /
[ Ikuta, A.;Itokawa, H. ] / Triterpenoids of Akebia Quinata callus tissue