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Neonatal Mitochondrial Respiratory Chain Defect and Vaginal Embryonal Rhabdomyosarcoma: Possibility of Oncogenesis?  

Cho, Min Su (Department of Pediatrics, Yonsei University College of Medicine)
Hur, Jin Ho (Department of Pediatrics, Yonsei University College of Medicine)
Park, Dae Young (Kojan Yonsei Pediatric Clinic)
Cho, SiHyun (Department of Obstetrics and Gynecology, Yonsei University College of Medicine)
Kim, Se Hoon (Department of Pathology, Yonsei University College of Medicine)
Lee, Young-Mock (Department of Pediatrics, Yonsei University College of Medicine)
Publication Information
Journal of The Korean Society of Inherited Metabolic disease / v.15, no.1, 2015 , pp. 25-28 More about this Journal
Abstract
Mitochondrial disorders are rare metabolic diseases. They often present during neonatal period but with nonspecific clinical features such as feeding difficulties, failure to thrive, and seizures. Mitochondrial defects have also known to be associated with neurological disorders, as well as cancers. We report the first case of neonatal mitochondrial respiratory chain defect with sarcoma botryoides confirmed by pathologic diagnosis, suggesting another possible link between mitochondrial dysfunction and cancer.
Keywords
Mitochondria; Respiratory chain defect; Neonate; Embryonal rhabdomyosarcoma; Oncogenesis;
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