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http://dx.doi.org/10.3831/KPI.2021.24.4.196

The Effect of Comfrey on Enoxaparin-Induced Bruise in Patients with Acute Coronary Syndrome: A Randomised Clinical Trial  

Bagheri, Zahra (Department of Medical Surgical Nursing, School of Nursing and Midwifery, Hamadan University of Medical Sciences)
Azizi, Azim (Chronic Diseases (Home Care) Research Center, Malayer School of Nursing, Hamadan University of Medical Sciences)
Oshvandi, Khodayar (Department of Medical Surgical Nursing, School of Nursing and Midwifery, Hamadan University of Medical Sciences)
Mohammadi, Younes (Department of Epidemiology, School of Public Health, Hamadan University of Medical Sciences)
Larki-Harchegani, Amir (Department of Pharmacology and Toxicology, School of Pharmacy, Hamadan University of Medical Sciences)
Publication Information
Journal of Pharmacopuncture / v.24, no.4, 2021 , pp. 196-205 More about this Journal
Abstract
Objectives: Bruising is an important side effect of enoxaparin injection. Comfrey (Symphytum officinale) is used to treat different types of wounds, bone fractures, and bruising in traditional medicine in many countries for centuries. This study aimed to determine the effects of the Comfrey ointment on the bruise size and color following enoxaparin injection. Methods: This double-blind randomized clinical trial was conducted on 80 patients with acute coronary syndrome (ACS). The participants were randomly divided into two groups of 40, namely Comfrey and Placebo. Changes in bruise size and color in both groups were assessed daily before and after the intervention. Results: The Comfrey and Placebo groups were homogeneous in demographic and clinical variables. A downward trend was observed in the bruise size in both groups throughout the study. However, the bruise size was smaller in the Comfrey group than the Placebo group on day 2-5 of the intervention. Moreover, there was a significant difference in bruise color between the groups, with a shorter healing course in the Comfrey group. Conclusion: The Comfrey ointment accelerated the healing process of enoxaparin injection-induced bruising in patients with ACS. It is recommended as a safe and simple approach for these patients.
Keywords
bruise; enoxaparin; comfrey; acute coronary syndrome; patient; ointment;
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