1 |
Martinez A, Rivas F, Perojil A, Parra A, Garcia-Granados A, Fernandez-Vivas A. Biotransformation of oleanolic and maslinic acids by Rhizomucor miehei. Phytochemistry. 2013;94:229-237.
DOI
|
2 |
Parmar S, Sharma T, Airao V, Bhatt R, Aghara R, Chavda S, Rabadiya SO, Gangwal AP. Neuropharmacological effects of triterpenoids. Phytopharmacology. 2013;4:354-372.
|
3 |
Pollier J, Goossens A. Oleanolic acid. Phytochemistry. 2012;77:10-15.
DOI
|
4 |
Maia JL, Lima-Junior RC, Melo CM, David JP, David JM, Campos AR, Santos FA, Rao VS. Oleanolic acid, a pentacyclic triterpene attenuates capsaicin-induced nociception in mice: possible mechanisms. Pharmacol Res. 2006;54:282-286.
DOI
|
5 |
Moreira DLF, de-Souza GHB, Rodrigues IV, Lopes NP, de Oliveira AR. A non-michaelian behavior of the in vitro metabolism of the pentacyclic triterpene alfa and beta amyrins by employing rat liver microsomes. J Pharm Biomed Anal. 2013;84:14-19.
DOI
|
6 |
Csuk R, Siewert B, Dressel C, Schafer R. Tormentic acid derivatives: synthesis and apoptic activity. Eur J Med Chem. 2012;56:237-245.
DOI
|
7 |
Mandal A, Ghosh S, Bothra AK, Nanda AK, Ghosh P. Synthesis of friedelan triterpenoid analogs with DNA topoisomerase inhibitory activity and their molecular docking studies. Eur J Med Chem. 2012;54:137-143.
DOI
|
8 |
American Cancer Society, Cancer Facts & Figures 2016, Atlanta: American Cancer Society; 2016.
|
9 |
International Agency for Research on Cancer and Cancer Research UK. World Cancer Factsheet, Cancer Research UK, London; 2012.
|
10 |
American Cancer Society. Cancer Facts & Figures 2013. Atlanta: American Cancer Society; 2013.
|
11 |
Ali I, Wani WA, Saleem K. Cancer scenario in India with future perspectives. Cancer Ther. 2011;8:56-70.
|
12 |
Hu Y, Fu L. Targeting cancer stem cells: a new therapy to cure cancer patients. Am J Cancer Res. 2012;2:340-356.
|
13 |
Ebner F, Schremmer-Danninger E, Rehbock J. The role of TP53 and p21 gene polymorphisms in breast cancer biology in a well specified and characterized German cohort. J Cancer Res Clin Oncol. 2010;136:1369-1375.
DOI
|
14 |
Mutai C, Abatis D, Vagias C, Moreau D, Roussakis C, Roussis V. Cytotoxic lupane-type triterpenoids from Acacia mellifera. Phytochemistry. 2004;65:1159-1164.
DOI
|
15 |
Ketron AC, Osheroff N. Phytochemicals as anticancer and chemopreventive topoisomerase II poisons. Phytochem Rev. 2013;13:19-35.
DOI
|
16 |
Sun H, Fang WS, Wang WZ, Hu C. Structure-activity relationships of oleanane-and ursane-type triterpenoids. Botanical Studies. 2006;47:339-368.
|
17 |
Chen Y, Williams V, Filippova M, Filippov V, Duerksen-Hughes P. Viral carcinogenesis: factors inducing DNA damage and virus integration. Cancers. 2014;6: 2155-2186.
DOI
|
18 |
Nath R, RoyS, De B, Choudhury MD. Anticancer and antioxidant activity of croton: a review. Int J Pharm Pharm Sci. 2013;5:63-70.
|
19 |
Ramachandran S, Prasad NR. Effect of ursolic acid, a triterpenoid antioxidant, on ultraviolet-B radiation-induced cytotoxicity, lipid peroxidation and DNA damage in human lymphocytes. Chem Biol Interact. 2008;176:99-107.
DOI
|
20 |
Pittayapan P. Health Insurance for Cancer Care in Asia: Thailand. Asia Pac J Oncol Nurs. 2016;3:54.
DOI
|
21 |
Sreedevi A, Javed R, Dinesh A. Epidemiology of cervical cancer with special focus on India. Int J Womens Health. 2015;7:405-414.
|
22 |
Dsouza ND, Murthy N, Aras R. Projection of cancer incident cases for India-till 2026. Asian Pac J Cancer Prev. 2013;14:4379-4386.
DOI
|
23 |
Dikshit R, Gupta PC, Ramasundarahettige C, Gajalakshmi V, Aleksandrowicz L, Badwe R, et al. Cancer mortality in India: a nationally representative survey. The Lancet. 2012;379:1807-1816.
DOI
|
24 |
James JT, Dubery IA. Pentacyclic triterpenoids from the medicinal herb, Centella asiatica (L.) Urban. Molecules. 2009;14:3922-3941.
DOI
|
25 |
Laszczyk MN. Pentacyclic triterpenes of the lupane, oleanane and ursane group as tools in cancer therapy. Planta med. 2009;75:1549-1560.
DOI
|
26 |
Reyes CP, Nunez MJ, Jimenez IA, Busserolles J, Alcaraz MJ, Bazzocchi IL. Activity of lupane triterpenoids from Maytenus species as inhibitors of nitric oxide and prostaglandin E 2. Bioorg Med Chem. 2006;14:1573-1579.
DOI
|
27 |
Yan XJ, Gong LH, Zheng FY, Cheng KJ, Chen ZS, Shi Z. Triterpenoids as reversal agents for anticancer drug resistance treatment. Drug Discov Today. 2014;19:482-488.
DOI
|
28 |
Yan J, Sun L, Zhang X, Li Z, Zhou L, Qiu M. Serratene Triterpenoids from Palhinhaea cernua var. sikkimensis. Chem Pharm Bull (Tokyo). 2009;57:1381-1384.
DOI
|
29 |
Shanmugam MK, Dai X, Kumar AP, Tan BK, Sethi G, Bishayee A. Ursolic acid in cancer prevention and treatment:molecular targets, pharmacokinetics and clinical studies. Biochem Pharmacol. 2013;85:1579-1587.
DOI
|
30 |
Furtado RA, Rodrigues EP, Araujo FR, Oliveira WL, Furtado MA, Castro MB, et al. Ursolic acid and oleanolic acid suppress preneoplastic lesions induced by 1, 2-dimethylhydrazine in rat colon. Toxicol Pathol. 2008;36:576-580.
DOI
|
31 |
Salminen A, Lehtonen M, Suuronen T, Kaarniranta K, Huuskonen J. Terpenoids: natural inhibitors of NF- signaling with anti-inflammatory and anticancer potential. Cell Mol Life Sci. 2008;65:2979-2999.
DOI
|
32 |
Wittayalai S, Sathalalai S, Thorroad S, Worawittayanon P, Ruchirawat S, Thasana N. Lycophlegmariols A-D: Cytotoxic serratene triterpenoids from the club moss Lycopodium phlegmaria L. Phytochemistry. 2012;76:117-123.
DOI
|
33 |
Lopez-Hortas L, Perez-Larran P, Gonzalez-Munoz MJ, Falque E, Dominguez H. Recent developments on the extraction and application of ursolic acid. A review. Food Research International. 2018;103:130-149.
DOI
|
34 |
Kangsamaksin T, Chaithongyot S, Wootthichairangsan C, Hanchaina R, Tangshewinsirikul C, Svasti J. Lupeol and stigmasterol suppress tumor angiogenesis and inhibit cholangiocarcinoma growth in mice via downregulation of tumor necrosis factor-. Plos One. 2017;12:1-16.
|
35 |
Turan I, Demir S, Kilinc K, Yaman SO, Misir S, Kara H, et al. Cytotoxic effect of Rosa canina extract on human colon cancer cells through repression of telomerase expression. Journal of Pharmaceutical Analysis. 2018;8(6):394-399.
DOI
|
36 |
Thoppil RJ, Bishayee A. Terpenoids as potential chemopreventive and therapeutic agents in liver cancer. World J Hepatol. 2011;3:228-249.
DOI
|
37 |
Gauthier C, Legault J, Lebrun M, Dufour P, Pichette A. Glycosidation of lupane-type triterpenoids as potent in vitro cytotoxic agents. Bioorg Med Chem. 2006;14:6713-6725.
DOI
|
38 |
Feng JH, Chen W, Zhao Y, Ju XL. Anti-tumor activity of oleanolic, ursolic and glycyrrhetinic acid. The Open Natural Products Journal. 2009;2:48-52.
DOI
|
39 |
Soldi C, Pizzolatti MG, Luiz AP, Marcon R, Meotti FC, Mioto LA, et al. Synthetic derivatives of the -and -amyrin triterpenes and their antinociceptive properties. Bioorg Med Chem. 2008;16:3377-3386.
DOI
|
40 |
Kvasnica M, Sarek J, Klinotova E, Dzubak P, Hajduch M. Synthesis of phthalates of betulinic acid and betulin with cytotoxic activity. Bioorg Med Chem. 2005;13:3447-3454.
DOI
|
41 |
Patocka J. Biologically active pentacyclic triterpenes and their current medicine signification. J Appl Biomed. 2003;1:7-12.
DOI
|
42 |
Bishayee A, Ahmed S, Brankov N, Perloff M. Triterpenoids as potential agents for the chemoprevention and therapy of breast cancer. Front Biosci. 2011;16:980.
DOI
|
43 |
Li ZJ, Yao C, Liu SF, Chen L, Xi YM, Zhang W, et al. Cytotoxic effect of icaritin and its mechanisms in inducing apoptosis in human burkitt lymphoma cell line. Biomed Res Int. 2014;1-7.
|
44 |
Andreeff M, Goodrich DW, Pardee AB. Cell proliferation, differentiation, and apoptosis. In: Kufe DW, Pollock RE, Weichselbaum RR editors. Holland-Frei Cancer Medicine. 6th edit. Hamilton (ON): BC Decker;2003.
|
45 |
Kaur J, Sharma M, Sharma P, Bansal MP. Antitumor activity of lantadenes in DMBA/TPA induced skin Tumors in mice: expression of transcription factors. Am J Biomed Sci. 2010;2:79-90.
|
46 |
Satomi Y, Nishino H, Shibata S. Glycyrrhetinic acid and related compounds induce G1 arrest and apoptosis in human hepatocellular carcinoma HepG2. Anticancer Res. 2005; 25:4043-4047.
|
47 |
Grace-Lynn C, Darah I, Chen Y, Latha LY, Jothy SL, Sasidharan S. In vitro antioxidant activity potential of lantadene A, a pentacyclic triterpenoid of Lantana plants. Molecules. 2012;17:11185-11198.
DOI
|
48 |
Patel S. A weed with multiple utility: Lantana camara. Reviews in Environmental Science and Bio/Technology. 2011;10:341-351.
DOI
|
49 |
Wang SR, Fang WS. Pentacyclic triterpenoids and their saponins with apoptosis-inducing activity. Curr Top Med Chem. 2009;9:1581-1596.
DOI
|
50 |
Sharma P, Allison JP. Immune checkpoint targeting in cancer therapy: toward combination strategies with curative potential. Cell. 2015;161:205-214.
DOI
|
51 |
Juan ME, Planas JM, Ruiz-Gutierrez V, Daniel H, Wenzel U. Antiproliferative and apoptosis-inducing effects of maslinic and oleanolic acids, two pentacyclic triterpenes from olives, on HT-29 colon cancer cells. Br J Nutr. 2008;100:36-43.
DOI
|
52 |
Sharma M, Sharma P, Bansal M, Singh J. Lantadene A-induced apoptosis in human leukemia HL-60 cells. Indian J Pharmacol. 2007;39:140.
DOI
|
53 |
Wynendaele W, OosteromVA, Pawinski A, De Bruijn EA, Maesi RA. Angiogenesis: possibilities for therapeutic interventions. Pharm World Sci. 1998;20:225-235.
DOI
|
54 |
Prasad S, Kalra N, Shukla Y. Induction of apoptosis by lupeol and mango extract in mouse prostate and LNCaP cells. Nutr Cancer. 2008;60:120-130.
DOI
|
55 |
Mu X, Shi W, Sun L, Li H, Li H, Jiang Z, et al. Pristimerin, a triterpenoid, inhibits tumor angiogenesis by targeting VEGFR2 activation. Molecules. 2012;17:6854-6868.
DOI
|
56 |
Senese S, Lo Y, Huang D, Zangle TA, Gholkar AA, Robert L, et al. Chemical dissection of the cell cycle: probes for cell biology and anti-cancer drug development. Cell Death Dis. 2014;5:e1462.
DOI
|
57 |
Janakiram NB, Indranie C, Malisetty SV, Jagan P, Steele VE, Rao CV. Chemoprevention of colon carcinogenesis by oleanolic acid and its analog in male F344 rats and modulation of COX-2 and apoptosis in human colon HT-29 cancer cells. Pharm Res. 2008;25:2151-2157.
DOI
|
58 |
Kanda T, Yokosuka O. The androgen receptor as an emerging target in hepatocellular carcinoma. J Hepatocell Carcinoma. 2015;2:91-99.
DOI
|
59 |
Fritz WA, Lin TM, Peterson RE. The aryl hydrocarbon receptor (AhR) inhibits vanadate-induced vascular endothelial growth factor (VEGF) production in TRAMP prostates. Carcinogenesis. 2008;29:1077-1082.
DOI
|
60 |
Lu JJ, Dang YY, Huang M, Xu WS, Chen XP, Wang YT. Anti-cancer properties of terpenoids isolated from Rhizoma Curcumae-A review. J Ethnopharmacol. 2012;143: 406-411.
DOI
|
61 |
Sun CC, Zhang YS, Xue X, Cheng YN, Liu HP, Zhao CR, et al. Inhibition of angiogenesis involves in anticancer activity of riccardin D, a macrocyclic bisbibenzyl, in human lung carcinoma. Eur J Pharmacol. 2011;667:136-143.
DOI
|
62 |
Swain SS, Rout KK, Chand PK. Production of triterpenoid anti-cancer compound taraxerol in Agrobacterium-transformed root cultures of butterfly pea (Clitoria ternatea L.). Appl Biochem Biotechnol. 2012;168:487-503.
DOI
|
63 |
Khanal P, Oh WK, Thuong PT, Cho SD, Choi HS. 24-Hydroxyursolic acid from the leaves of the Diospyros kaki (Persimmon) induces apoptosis by activation of AMP-activated protein kinase. Planta Med. 2010;76:689-693.
DOI
|
64 |
Neto CC. Ursolic acid and other pentacyclic triterpenoids: anticancer activities and occurrence in berries. Berries and Cancer Prevention. Springer New York; 2011.
|
65 |
Kim SS, Won SJ, Kim NJ, Cho SD, Choi HS. 3-Oxoolean-12-en-27-oic acid isolated from Aceriphyllum rossii induces caspase-8-dependent apoptosis in human promyelocytic leukemia HL-60 cells. Biol Pharm Bull. 2009;32:91-98.
DOI
|
66 |
Youn SH, Lee JS, Lee MS, Cha EY, Thuong PT, Kim JR, Chang ES. Anticancer properties of pomolic acid-induced AMP-activated protein kinase activation in MCF7 human breast cancer cells. Biol Pharm Bull. 2012;35:105-110.
DOI
|
67 |
Harsh M. Textbook of pathology. Jaypee Brothers Medical Publishers. New Delhi; 2010.
|
68 |
Singh MP, Kumar V, Agarwal A, Kumar R, Bhatt ML, Misra S. Clinico-epidemiological study of oral squamous cell carcinoma: A tertiary care centre study in North India. J Oral Biol Craniofac Res. 2016;6:32-35.
DOI
|
69 |
Loney T, Aw TC, Handysides DG Ali R, Blair I, Grivna M, Shah SM, et al. An analysis of the health status of the United Arab Emirates: the 'Big 4'public health issues. Global health action. 2013;6:1-8.
DOI
|
70 |
Dhanamani M, Devi SL, Kannan S. Ethnomedicinal plants for cancer therapy - a review. Hygeia JD Med. 2011;3:1-10.
|
71 |
Rang HP, Ritter JM, Flower RJ. Rang and Dale's Pharmacology: With student consult online access: Elsevier Health Sciences. 7th edition. Churchill Livingstone: Edinburgh; 2012.
|
72 |
Wang FZ, Yang NN, Zhao YL, Liu QQ, Fei HR, Zhang JG. PF-04691502 triggers cell cycle arrest, apoptosis and inhibits the angiogenesis in hepatocellular carcinoma cells. Toxicol Lett. 2013;220:150-156.
DOI
|
73 |
Niedzwiecki A, Roomi MW, Kalinovsky T, Rath M. Anticancer Efficacy of Polyphenols and Their Combinations. Nutrients. 2016;8:552.
DOI
|
74 |
Safarzadeh E, ShotorbaniSS, Baradaran B. Herbal medicine as inducers of apoptosis in cancer treatment. Adv Pharm Bull. 2014;4:421-427.
|
75 |
Fabio GD, Romanucci V, De Marco A, Zarrelli A. Triterpenoids from Gymnema sylvestre and their pharmacological activities. Molecules. 2014;19:10956-10981.
DOI
|
76 |
Pratheeshkumar P, Sreekala C, Zhang Z, Budhraja A, Ding S, Son YO, Wang X, Hitron A, Hyun-Jung K, Wang L, Lee JC. Cancer prevention with promising natural products: mechanisms of action and molecular targets. Anticancer Agents Med Chem. 2012;12:1159-1184.
DOI
|
77 |
Shu L, Cheung KL, Khor TO, Chen C, Kong AN. Phytochemicals: cancer chemoprevention and suppression of tumor onset and metastasis. Cancer Metastasis Rev. 2010;29:483-502.
DOI
|
78 |
Muffler K, Leipold D, Scheller MC, Haas C, Steingroewer J, Bley T, Neuhaus HE, Mirata MA, Schrader J, Ulber R. Biotransformation of triterpenes. Process Biochemistry. 2011;46:1-15.
DOI
|