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http://dx.doi.org/10.3831/KPI.2014.17.010

Analgesic Effects of Toad Cake and Toad-cake-containing Herbal Drugs -Analgesic effects of toad cake-  

Inoue, Eiji (Tokyo Research Center, Kyushin Pharmaceutical Co., Ltd.)
Shimizu, Yasuharu (Tokyo Research Center, Kyushin Pharmaceutical Co., Ltd.)
Masui, Ryo (Tokyo Research Center, Kyushin Pharmaceutical Co., Ltd.)
Usui, Tomomi (Tokyo Research Center, Kyushin Pharmaceutical Co., Ltd.)
Sudoh, Keiichi (Tokyo Research Center, Kyushin Pharmaceutical Co., Ltd.)
Publication Information
Journal of Pharmacopuncture / v.17, no.1, 2014 , pp. 74-79 More about this Journal
Abstract
Objectives: This study was conducted to clarify the analgesic effect of toad cake and toad-cake-containing herbal drugs. Methods: We counted the writhing response of mice after the intraperitoneal administration of acetic acid as a nociceptive pain model and the withdrawal response after the plantar surface stimulation of the hind paw induced by partial sciatic nerve ligation of the mice as a neuropathic pain model to investigate the analgesic effect of toad cake and toad-cake-containing herbal drugs. A co-treatment study with serotonin biosynthesis inhibitory drug 4-chloro-DL-phenylalanine methyl ester hydrochloride (PCPA), the catecholamine biosynthesis inhibitory drug ${\alpha}$-methyl-DL-tyrosine methyl ester hydrochloride (AMPT) or the opioid receptor antagonist naloxone hydrochloride was also conducted. Results: Analgesic effects in a mouse model of nociceptive pain and neuropathic pain were shown by oral administration of toad cake and toad-cake-containing herbal drugs. The effects of toad cake and toad-cake-containing herbal drugs disappeared upon co-treatment with PCPA, but not with AMPT or naloxone in the nociceptive pain model; the analgesic effect of toad-cake-containing herbal drugs also disappeared upon co-treatment with PCPA in the neuropathic pain model. Conclusion: Toad cake and toad-cake-containing herbal drugs have potential for the treatments of nociceptive pain and of neuropathic pain, such as post-herpetic neuralgia, trigeminal neuralgia, diabetic neuralgia, and postoperative or posttraumatic pain, by activation of the central serotonin nervous system.
Keywords
neuropathic pain; nociceptive pain; serotonin; toad cake;
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