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http://dx.doi.org/10.3831/KPI.2011.14.4.005

Effects of Glycyrrhizae Radix Pharmacopuncture Intravenous Injection on Ischemia-Induced Acute Renal Failure in Rabbits  

Kim, Hyeong-Cheol (Dong-Eui University College of Oriental Medicine)
Kim, Gyoung-Ho (Pusan National University School of Korean Medicine)
Lee, Guem-San (Pusan National University School of Korean Medicine)
Kim, Hyung-Woo (Pusan National University School of Korean Medicine)
Lim, Se-Hyun (Department of Nursing, Far East University College of Public Health)
Lim, Chi-Yeon (Department of Medicine, Dongguk University College of Medicine)
Kim, Young-Gyun (Dong-Eui University College of Oriental Medicine)
Cho, Su-In (Pusan National University School of Korean Medicine)
Publication Information
Journal of Pharmacopuncture / v.14, no.4, 2011 , pp. 5-11 More about this Journal
Abstract
Objectives: The present study was undergone to determine whether Glycyrrhizae Radix pharmacopuncture intravenous injection exerts beneficial effect against the ischemia-induced acute renal failure in rabbits. Methods: Rabbits were treated with Glycyrrhizae Radix pharmacopuncture via i.v., followed by renal ischemia/reperfusion. The fractional excretion of glucose and phosphate were measured and the malondialdehyde content was also determined. The morphological changes of cortical part of kidney also observed with light microscope. Results: Renal ischemia/reperfusion caused increase of the fractional excretion of glucose and phosphate in ischemia-induced animals, which was prevented by Radix Glycyrrhizae extract treatment. Ischemia/reperfusion increased lipid peroxidation, which was prevented and morphological changes also altered by Radix Glycyrrhizae pharmacopuncture administration. Conclusions: These results indicate that lipid peroxidation plays a critical role in ischemia-induced acute renal failure and Glycyrrhizae Radix pharmacopuncture exerts the protective effect against acute renal failure induced by renal ischemia/reperfusion.
Keywords
Glycyrrhizae Radix; pharmacopuncture; ischemia; renal failure;
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Times Cited By KSCI : 8  (Citation Analysis)
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