Browse > Article
http://dx.doi.org/10.3831/KPI.2011.14.3.063

Effect of Artemisia capillaries on Gene Expression of Lipid Metabolism in Rat  

Jang, Woo-Seok (Department of Internal Medicine, Daegu-Haany University College of Oriental Medicine)
Publication Information
Journal of Pharmacopuncture / v.14, no.3, 2011 , pp. 63-69 More about this Journal
Abstract
Objectives : The purpose of this study is to evaluate the effect of Artemisia capillaries on gene expression of lipid metabolism in rats. Methods : The author performed several experimental items to analyze the total cholesterol and triglyceride in liver tissue, the gene expressions of CYP7A1 and HMG-CoA reductase. Results : 1. In Artemisia capillaries group, the levels of total cholesterol in liver tissue were significantly decreased. 2. In Artemisia capillaries group, the ratios of CYP7A1, HMG-CoA reductase were as same as the normal group. Conclusions : From the above results, Artemisia capillaries can be used to treat hyperlipidemia.
Keywords
Artemisia capillaries; Hyperlipidemia; Gene expression;
Citations & Related Records
Times Cited By KSCI : 9  (Citation Analysis)
연도 인용수 순위
1 Kim SC, Seo BI. Bonchojibseong. Seoul:Tree and earth. 2000:368-70.
2 Suagee JK, Corl BA, Crisman MV, Wearn JG, McCutcheon LJ, Geor RJ. De novo fatty acid synthesis and NADPH generation in equine adipose and liver tissue. Comp Biochem Physiol B Biochem Mol Biol. 2010;155(3):322-6.   DOI   ScienceOn
3 Ham IH, Jung SW, Lee KJ, Park KH, Choi HY. Effect of the aerial part of Artemisia capillaris and A. iwayomogi on the Hyperlipidemia of Rats induced by Triton WR-1339. Kor. J. Herbology. 2005;20(1):46.
4 Youh EJ, Seo BK, Huang B, Kim JI, Kang SK. Artemisia capillaries Herbal Acupuncture Improves Metabolic Abnormalities in High Fat Diet-induced Obese ICR Mice. The Journal of Korean Acupuncture & Moxibustion. 2011;28(1):1-12.   과학기술학회마을
5 Choi JS, Yim YK, Lee BR, Yang GY, Kim JK. The Effect of Achyranthis Radix Herbalacupuncture on Hyperlipidemia in Rats. Korean Journal of Acupuncture. 2010;27(3):25-6.
6 Lee JT, Lee BR, Yang GY, Lee H, Yim YK. A Study on the Effect of Herbal-acupuncture with Artemisiae Carpillaris Herba at GB34 on Hyperlipidemia in Rat. Journal of Meridian & Acupoint. 2010;27(1):107,118.
7 Park JY, Song CH. The Effect of Bupleuri Radix Herbal-acupuncture at GB34(Yangneungcheon) on Hyperlipidemia in Rats. Korean Journal of Acupuncture. 2010;27(2):121,133.   과학기술학회마을
8 An GH, Lee H. The Effect of Cnidii Rhizoma Herbal-acupuncture at GB34(Yangneungcheon) on Hyperlipidemia in Rats. The Journal of Korean Acupuncture & Moxibustion. 2010;27(4):138,143.   과학기술학회마을
9 Lee SH, Lee H. A Study on the Effect of Herbal-acupuncture with Schizandrae Fructus Solution on Hyperlipidemia in Rats Induced by High Fat Diet. The Journal of Korean Acupuncture & Moxibustion. 2011;28(2):149.   과학기술학회마을
10 Song WG, Kang JH, Lee H. The Effect of Puerariae Radix Herbal-acupuncture at GB34(Yangneungcheon) on Hyperlipidemia in Rats. The Journal of Korean Acupuncture & Moxibustion. 2009;26(4):80,86.
11 An YS, Ahn TW, Kang HJ, Lee YH, Yim YK. The Effect of Herbal-acupuncture with Moutan Cortex Radix Extract. Journal of Meridian & Acupoint. 2009;26(1):101.
12 Johnston TP. Poloxamer-407 as a general lipase inhibitor: its implications in lipid metabolism and atheroma formation in C57BL/6 mice. J Pharm Pharmacol. 2010;62(12):1807-12.   DOI   ScienceOn
13 Cheon WK, Lim KW. Effects of High-fat Diet Feeding on HMG-CoA Reductase mRNA Levels of Skeletal Muscle in Rats. The Korean Journal of Exercise Nutrition. 2010;14(3):145-6,148.
14 Pfizer 2008 Annual Report. Pfizer. http://media.pfizer.com/files/annualreport/2008/annual/review2008.pdf.
15 Bertram G. Katzung. BASIC & CLINICAL PHARMACOLOGY. Seoul:KMS. 2008:589,593.
16 Yang JL, Lee HJ, Kim YH. Effect of Hormones and Short Chain Fatty Acids on CYP7A1 Gene Expression in HepG2 Cell. J Korean Soc Food Sci Nutr. 2005;34(5):537.   과학기술학회마을   DOI   ScienceOn