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http://dx.doi.org/10.3961/jpmph.21.387

Association Between Low Muscle Mass and Non-alcoholic Fatty Liver Disease Diagnosed Using Ultrasonography, Magnetic Resonance Imaging Derived Proton Density Fat Fraction, and Comprehensive NAFLD Score in Korea  

Lee, Hun Ju (Department of Preventive Medicine, Yonsei Wonju University College of Medicine)
Chang, Jae Seung (Department of Physiology, Yonsei University Wonju College of Medicine)
Ahn, Jhii Hyun (Department of Radiology, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine)
Kim, Moon Young (Department of Internal Medicine, Yonsei University Wonju College of Medicine)
Park, Kyu-Sang (Department of Physiology, Yonsei University Wonju College of Medicine)
Ahn, Yeon-Soon (Department of Preventive Medicine, Yonsei Wonju University College of Medicine)
Koh, Sang Baek (Department of Preventive Medicine, Yonsei Wonju University College of Medicine)
Publication Information
Journal of Preventive Medicine and Public Health / v.54, no.6, 2021 , pp. 412-421 More about this Journal
Abstract
Objectives: Non-alcoholic fatty liver disease (NAFLD) is an increasingly prevalent metabolic disease. Muscle is known to influence NAFLD development. Therefore, this study aimed to determine the relationships among low muscle mass, NAFLD, and hepatic fibrosis using various definitions of low muscle mass and NAFLD diagnostic methods, including magnetic resonance imaging-based proton density fat fraction (MRI-PDFF). Methods: This cross-sectional study included 320 participants (107 males, 213 females) from the Korean Genome and Epidemiology Study on Atherosclerosis Risk of Rural Areas in the Korean General Population cohort. Muscle mass was assessed using whole-body dual-energy X-ray absorptiometry and adjusted for the height squared, body weight, and body mass index (BMI). NAFLD was diagnosed using ultrasonography (US), MRI-PDFF, and the comprehensive NAFLD score (CNS). Hepatic fibrosis was assessed using magnetic resonance elastography. Multivariable logistic and linear regression analyses were performed to determine the aforementioned associations. Results: According to US, 183 participants (57.2%) had NAFLD. Muscle mass adjusted for body weight was associated with NAFLD diagnosed using US (odds ratio [OR], 3.00; 95% confidence interval [CI], 1.70 to 5.31), MRI-PDFF (OR, 2.00; 95% CI, 1.13 to 3.53), and CNS (OR, 3.39; 95% CI, 1.73 to 6.65) and hepatic fibrosis (males: β=-0.070, p<0.01; females: β=-0.037, p<0.04). Muscle mass adjusted for BMI was associated with NAFLD diagnosed by US (OR, 1.71; 95% CI, 1.02 to 2.86) and CNS (OR, 1.95; 95% CI, 1.04 to 3.65), whereas muscle mass adjusted for height was not associated with NAFLD. Conclusions: Low muscle mass was associated with NAFLD and liver fibrosis; therefore, maintaining sufficient muscle mass is important to prevent NAFLD. A prospective study and additional consideration of muscle quality are needed to strengthen the findings regarding this association.
Keywords
Non-alcoholic fatty liver disease; Sarcopenia; Liver cirrhosis; Fibrosis;
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