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http://dx.doi.org/10.3961/jpmph.2011.44.6.260

Arterial Stiffness is Associated With Diabetic Retinopathy in Korean Type 2 Diabetic Patients  

Yun, Yong-Woon (Department of Preventive Medicine, Chonnam National University Medical School)
Shin, Min-Ho (Department of Preventive Medicine, Chonnam National University Medical School)
Lee, Young-Hoon (Department of Preventive Medicine, Wonkwang University Medical School)
Rhee, Jung-Ae (Department of Preventive Medicine, Chonnam National University Medical School)
Choi, Jin-Su (Department of Preventive Medicine, Chonnam National University Medical School)
Publication Information
Journal of Preventive Medicine and Public Health / v.44, no.6, 2011 , pp. 260-266 More about this Journal
Abstract
Objectives: We evaluated the association between common carotid artery intima-media thickness (CCA-IMT), brachialankle pulse wave velocity (baPWV), carotid plaque, and peripheral arterial disease (PAD) as indicators of macroangiopathy and diabetic retinopathy as an indicator of microangiopathy in type 2 diabetic patients. Methods: We analyzed 605 type 2 diabetic patients registered at a public health center in Korea. Following overnight fasting, venous blood and urine samples were collected and analyzed. The CCA-IMT, levels of carotid plaque, baPWV, and ankle-brachial index (ABI) of the subjects were assessed. We used non-mydriatic fundus photography to diagnose diabetic retinopathy. Multiple logistic regression analyses were used to evaluate the association between macroangiopathy and diabetic retinopathy. CCA-IMT and baPWV were divided into tertiles: CCA-IMT, 0.39 to 0.65 mm, 0.66 to 0.78 mm, and 0.79 to 1.30 mm; baPWV, 9.9 to 15.8 m/s, 15.9 to 18.9 m/s, and 19.0 to 38.0 m/s. Results: The association between baPWV and diabetic retinopathy remained significant after adjustment, with an increasing odds ratio (OR) in the second tertile (OR, 2.41; 95% confidence interval [CI], 1.27 to 4.55) and the third tertile (OR, 4.63; 95% CI, 2.33 to 9.21). No significant differences were observed in carotid plaque, PAD, and each tertile of CCA-IMT. Conclusions: BaPWV was associated with diabetic retinopathy, while CCA-IMT, carotid plaque, and PAD were not. This study suggests that the association between macroangiopathy and microangiopathy may be attributable to functional processes rather than structural processes within the vascular system.
Keywords
Carotid plaque; Diabetes mellitus; Diabetic retinopathy; Intima-media thickness; Peripheral arterial disease; Pulse wave velocity;
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