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A Cross-Sectional Study on ${\gamma}-GTP$ and its Related Factors in Male Workers  

Kim, Keon-Yeop (Department of Preventive Medicine, School of Medicine, Kyungpook National University)
Lee, Jong-Hyun (Department of Preventive Medicine, School of Medicine, Kyungpook National University)
Ha, Young-Ae (Ulsan Dong Kang Hospital)
Lee, Kyung-Eun (Department of Preventive Medicine, School of Medicine, Kyungpook National University)
Kam, Sin (Department of Preventive Medicine, School of Medicine, Kyungpook National University)
Publication Information
Journal of Preventive Medicine and Public Health / v.35, no.2, 2002 , pp. 169-174 More about this Journal
Abstract
Objective : To investigate gamma-Glutamyltransferase (${\gamma}-GTP$) and its related factors in male industrial workers. Method : Five hundred and tony male workers without heart disease, diabetes mellitus, renal disease, hepatitis, and other liver diseases were surveyed in October 1998. Blood samples were collected to test for ${\gamma}-GTP$, total-cholesterol and fasting blood glucose. A self-administered questionnaire survey on life style was also done. Results : The total geometric mean value of ${\gamma}-GTP$ was 30.6 U/L. According to a univariate analysis: age, BMI(body mass index, $kg/m^2$), alcohol consumption, current smoking, stress, diastolic blood pressure, and blood total cholesterol were significantly associated with ${\gamma}-GTP$(p<0.05). From a multiple regression analysis: BMI, alcohol consumption, current smoking, diastolic blood pressure and total-cholesterol were significantly related to ${\gamma}-GTP$(p<0.05). Coffee consumption was negatively related to ${\gamma}-GTP$, but not significantly. Conclusion : We recommend that a change in health behavior (i.e. reducing alcohol intake, controlling BMI and not smoking) is necessary to decrease ${\gamma}-GTP$ in male workers.
Keywords
gamma-Glutamyltransferase; Male;
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  • Reference
1 통계청. 사망원인통계연보. 1999
2 Poikolainen K, Vartiainen E. Determinants of ${\gamma}$-GTP : positive interaction with alcohol and BMI, negative association with coffee. Am J Epidemiol 1997; 146 (12): 1019-1024   DOI   PUBMED
3 Nilssen O, Forde OH, Brenn T. Distribution and population determinants of ${\gamma}$ -GTP. Am J Epidemiol 1990; 132(2): 318-326   DOI   PUBMED
4 대한가정의학회. 한국인의 건강증진; 1996
5 Bae JM, Jeong EK, Yoo TW, Heh BY, Kim CH. A quick measurement of stress in outpatient clinic setting. Fam Med 1992; 13(10): 809-820 (Korean)
6 하영애. 남성 근로자들에서 간기능검사 이상소견 발생률과 관련요인. 경북대학교 의학 박사학위논문; 1999
7 이덕희, 하명화, 이송권. ${\gamma}$-GTP가 고혈압 발생에 미치는 영향 -철강제조업체 근로자들을 대상으로 한 4년 추구연구-. 대한예방의학회 추계학술대회 초록집; 1999,(154쪽)
8 Cheong HK, Lim HS, Kim GH. A baseline study on the choice of optimal screening test items among workers with abnormal liver function tests on workers' periodic health examination. Korean J Prev Med 1994; 27(4): 747-761 (Korean)
9 대한예방의학회. 건강 통계 자료 수집 및 측정의 표준화 연구; 1993
10 Sharp DS, Benowita NL. Re:' Alcohol, smoking, coffee, and cirrhosis' and 'Coffee and serum ${\gamma}$-GTP: a study of self-defense officials in Japan' (Letter). Am J Epidemiol 1995; 141: 480-481   DOI   PUBMED
11 서울대학교 의과대학 내과학교실. 최신지견 내과학. 1996, (458쪽)
12 Wannamethee G, Ebrahim S, Shaper AG. ${\gamma}$-GTP : determinants and association with mortality from ischemic heart disease and all causes. Am J Epidemiol 1995; 142(7): 699-708   DOI   PUBMED
13 Rosalki SB, Rau D. Serum ${\gamma}$-GTP activity in alcoholism. Clin Chemica Acta 1972; 39: 41   DOI   ScienceOn
14 Lee YJ, Ahn JE, Kim JJ, Lee BK. A retrospective cohort study on the effect of health counselling through the level of ${\gamma}$-GTP after screening test. Korean J Prev Med 1997; 30(3): 518-529 (Korean)
15 Klastsky AL, Armstrong MA. Alcohol, smoking, coffee and cirrhosis. Am J Epidemiol 1992; 136(10): 1248-1257   DOI
16 Kim IP, Kim KH. Diagnostic Usefulness of serum ${\gamma}$-GTP activity in various diseases. Newest Medical J 1975; 18(11): 1389-1399 (Korean)
17 Nilssen O, Forde OH. Seven-year longitudinal population study of change in ${\gamma}$ -GTP: the Tromso study. Am J Epidemiol 1994; 139(8): 787-792   DOI   PUBMED
18 Bae JM, Park BJ, Lee MS, Kim DH, Shin MH, Ahn YO. Association of liver dysfunction with self-medication history in Korean healthy male adults. Korean J Prev Med 1996; 29(4): 801-813 (Korean)
19 Hanes CS, Hird FJR, Isherwood FA. Enzymatic transpeptidation reactions involving ${\gamma}$ -GTP and ${\alpha}$-amino acyl peptides. J Biochemistry 1952; 51: 25   DOI
20 Gill JS, Zezulka AV, Shipley MJ, Gill SK, Beevers DG. Stroke and alcohol consumption. N Engl J Med 1986; 315: 1041-1046   DOI   PUBMED   ScienceOn
21 Yamada Y, Ishizaki M, Kido T, Honda R, Tsuritani I, Nogawa K, Yamaya H. Relationship between serum ${\gamma}$-GTP activity, blood pressure and alcohol consumption. J Hum Hypertens 1989: 3: 409-417   PUBMED
22 Lieber CS. Hepatic and metabolic effects of ethanol: pathogenesis and prevention. Ann Med 1994; 26: 325-330   DOI
23 노동부. 1997년 근로자 건강진단 실시 결과; 1998
24 Kono S, Shinchi K, Imanishi K, Todoroki I, Hatsuse K. Coffee and serum ${\gamma}$-GTP : a study of self-defense officials in japan. Am J Epidemiol 1994; 139(7): 723-727   DOI   PUBMED
25 Hanes CS, Hird FJR, Isherwood FA. Synthesis of peptides in enzymic reactions involving glutathione. Nature 1950; 166: 288   DOI   ScienceOn
26 Jacobs WLW. ${\gamma}$-GTP in diseases of the liver, cardiovascular system and diabetes mellitus. Clin Chern Acta 1972; 38: 419-434   DOI   ScienceOn
27 Kim SH, Lee YW, Kim KH. Normal serum ${\gamma}$-GTP activity of normal Koreans. Newest Medical J 1976; 19(1): 95-104 (Korean)
28 Moriya S, Nagata S, Yokoyama H, Kato S, Horie Y, Ito T, Ebihara Y, Ishii H. Expression of ${\gamma}$-GTP mRNA after depletion of glutathione in rat liver. Alcohol 1994; 29: S1: 107-111
29 Shaper AG, Wannamethee G, Whincup PH. Alcohol and blood pressure in middle-aged British men. J Hum Hypertens 1988; 2: 71-78   PUBMED