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http://dx.doi.org/10.3904/kjim.2015.125

Prevalence and possible causes of hypouricemia at a tertiary care hospital  

Son, Chang-Nam (Department of Internal Medicine, Keimyung University Dongsan Medical Center)
Kim, Ji-Min (Department of Internal Medicine, Keimyung University Dongsan Medical Center)
Kim, Sang-Hyon (Department of Internal Medicine, Keimyung University Dongsan Medical Center)
Cho, Soo-Kyung (Department of Rheumatology, Hospital for Rheumatic Diseases, Hanyang University College of Medicine)
Choi, Chan-Bum (Department of Rheumatology, Hospital for Rheumatic Diseases, Hanyang University College of Medicine)
Sung, Yoon-Kyoung (Department of Rheumatology, Hospital for Rheumatic Diseases, Hanyang University College of Medicine)
Kim, Tae-Hwan (Department of Rheumatology, Hospital for Rheumatic Diseases, Hanyang University College of Medicine)
Bae, Sang-Cheol (Department of Rheumatology, Hospital for Rheumatic Diseases, Hanyang University College of Medicine)
Yoo, Dae-Hyun (Department of Rheumatology, Hospital for Rheumatic Diseases, Hanyang University College of Medicine)
Jun, Jae-Bum (Department of Rheumatology, Hospital for Rheumatic Diseases, Hanyang University College of Medicine)
Publication Information
The Korean journal of internal medicine / v.31, no.5, 2016 , pp. 971-976 More about this Journal
Abstract
Background/Aims: We aimed to investigate the prevalence and possible causes of hypouricemia in the Korean population and to compare our findings with published results of other populations. Methods: We examined the serum uric acid levels of 30,757 subjects who had their uric acid values measured at least once during a 1-year period. All individuals with hypouricemia (serum uric acid < 2.0 mg/dL, n = 424) were reviewed with respect to medical drug history and concomitant diseases previously identified as being associated with hypouricemia. Results: The prevalence of hypouricemia was 4.14% (299/7,223) among inpatients and 0.53% (125/23,534) among outpatients, for an overall prevalence of 1.39% (424/30,757). Possible causes associated with hypouricemia were found to be solid or hematologic malignancies (n = 86), diabetes mellitus (n = 56), and therapeutic drugs (n = 29). The medications were allopurinol (n = 11), angiotensin II receptor blockers (n = 10), salicylates (n = 6), febuxostat (n = 1), and warfarin (n = 1). In the remaining 226 individuals, the cause of hypouricemia was not identified. Conclusions: Hypouricemia is relatively common in the Korean population compared to those of other countries. The possible causes associated with hypouricemia are related to underlying diseases and medications.
Keywords
Hypouricemia; Uric acid;
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