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http://dx.doi.org/10.3904/kjim.2015.227

Validation of the Korean coefficient for the modification of diet in renal disease study equation  

Oh, Yun Jung (Department of Internal Medicine, Cheju Halla General Hospital)
Cha, Ran-hui (Department of Internal Medicine, National Medical Center)
Lee, Seung Hwan (Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine)
Yu, Kyung Sang (Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine)
Kim, Satbyul Estella (Department of Epidemiology and Biostatistics, Seoul National University School of Public Health)
Kim, Ho (Department of Epidemiology and Biostatistics, Seoul National University School of Public Health)
Kim, Yon Su (Department of Internal Medicine, Seoul National University College of Medicine)
Publication Information
The Korean journal of internal medicine / v.31, no.2, 2016 , pp. 344-356 More about this Journal
Abstract
Background/Aims: Race and ethnicity are important determinants when estimating glomerular filtration rate (GFR). The Korean coefficients for the isotope dilution mass spectrometry (IDMS) Modification of Diet in Renal Disease (MDRD) Study equations were developed in 2010. However, the coefficients have not been validated. The aim of this study was to validate the performance of the Korean coefficients for the IDMS MDRD Study equations. Methods: Equation development and validation were performed in separate groups (development group, n = 147 from 2008 to 2009; validation group, n = 125 from 2010 to 2012). We compared the performance of the original IDMS MDRD equations and modified equations with Korean coefficients. Performance was assessed by comparing correlation coefficients, bias, and accuracy between estimated GFR and measured GFR, with systemic inulin clearance using a single injection method. Results: The Korean coefficients for the IDMS MDRD equations developed previously showed good performance in the validation group. The new Korean coefficients for the four- and six-variable IDMS MDRD equations using both the development and validation cohorts were 1.02046 and 0.97300, respectively. No significant difference was detected for the new Korean coefficients, in terms of estimating GFR, between the original and modified IDMS MDRD Study equations. Conclusions: The modified equations with Korean coefficients for the IDMS MDRD Study equations were not superior to the original equations for estimating GFR. Therefore, we recommend using the original IDMS MDRD Study equation without ethnic adjustment in the Korean population.
Keywords
Coefficients; Glomerular filtration rate; Equation; Inulin clearance;
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