Concomitant inhibition of renin angiotensin system and Toll-like receptor 2 attenuates renal injury in unilateral ureteral obstructed mice |
Chung, Sarah
(Department of Internal Medicine, Chungnam National University School of Medicine)
Jeong, Jin Young (Department of Internal Medicine, Chungnam National University School of Medicine) Chang, Yoon Kyung (Department of Internal Medicine, College of Medicine, Daejeon St. Mary's Hospital, The Catholic University of Korea) Choi, Dae Eun (Department of Internal Medicine, Chungnam National University School of Medicine) Na, Ki Ryang (Department of Internal Medicine, Chungnam National University School of Medicine) Lim, Beom Jin (Department of Pathology, Yonsei University College of Medicine) Lee, Kang Wook (Department of Internal Medicine, Chungnam National University School of Medicine) |
1 | Min HS, Kim JE, Lee MH, et al. Effects of Toll-like receptor antagonist 4,5-dihydro-3-phenyl-5-isoxasole acetic acid on the progression of kidney disease in mice on a high-fat diet. Kidney Res Clin Pract 2014;33:33-44. DOI |
2 | Leemans JC, Stokman G, Claessen N, et al. Renal-associated TLR2 mediates ischemia/reperfusion injury in the kidney. J Clin Invest 2005;115:2894-2903. DOI |
3 | Wu H, Chen G, Wyburn KR, et al. TLR4 activation mediates kidney ischemia/reperfusion injury. J Clin Invest 2007;117:2847-2859. DOI |
4 | Pulskens WP, Teske GJ, Butter LM, et al. Toll-like receptor-4 coordinates the innate immune response of the kidney to renal ischemia/reperfusion injury. PLoS One 2008;3:e3596. DOI |
5 | Leemans JC, Butter LM, Pulskens WP, et al. The role of Toll-like receptor 2 in inflammation and fibrosis during progressive renal injury. PLoS One 2009;4:e5704. DOI |
6 | Chowdhury P, Sacks SH, Sheerin NS. Endogenous ligands for TLR2 and TLR4 are not involved in renal injury following ureteric obstruction. Nephron Exp Nephrol 2010;115:e122-e130. DOI |
7 | Esteban V, Lorenzo O, Ruperez M, et al. Angiotensin II, via AT1 and AT2 receptors and NF-kappaB pathway, regulates the inflammatory response in unilateral ureteral obstruction. J Am Soc Nephrol 2004;15:1514-1529. DOI |
8 | Chevalier RL, Forbes MS, Thornhill BA. Ureteral obstruction as a model of renal interstitial fibrosis and obstructive nephropathy. Kidney Int 2009;75:1145-1152. DOI |
9 | Choi DE, Jeong JY, Lim BJ, et al. Aliskiren ameliorates renal inflammation and fibrosis induced by unilateral ureteral obstruction in mice. J Urol 2011;186:694-701. DOI |
10 | Kaneto H, Morrissey J, McCracken R, Reyes A, Klahr S. Enalapril reduces collagen type IV synthesis and expansion of the interstitium in the obstructed rat kidney. Kidney Int 1994;45:1637-1647. DOI |
11 | Taylor KR, Trowbridge JM, Rudisill JA, Termeer CC, Simon JC, Gallo RL. Hyaluronan fragments stimulate endothelial recognition of injury through TLR4. J Biol Chem 2004;279:17079-17084. DOI |
12 | Saemann MD, Weichhart T, Zeyda M, et al. Tamm-Horsfall glycoprotein links innate immune cell activation with adaptive immunity via a Toll-like receptor-4-dependent mechanism. J Clin Invest 2005;115:468-475. DOI |
13 | Schaefer L, Babelova A, Kiss E, et al. The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophages. J Clin Invest 2005;115:2223-2233. DOI |
14 | Scheibner KA, Lutz MA, Boodoo S, Fenton MJ, Powell JD, Horton MR. Hyaluronan fragments act as an endogenous danger signal by engaging TLR2. J Immunol 2006;177:1272-1281. DOI |
15 | Burns WC, Velkoska E, Dean R, Burrell LM, Thomas MC. Angiotensin II mediates epithelial-to-mesenchymal transformation in tubular cells by ANG 1-7/MAS-1-dependent pathways. Am J Physiol Renal Physiol 2010;299:F585-F593. DOI |
16 | Wolf G, Bohlender J, Bondeva T, Roger T, Thaiss F, Wenzel UO. Angiotensin II upregulates Toll-like receptor 4 on mesangial cells. J Am Soc Nephrol 2006;17:1585-1593. DOI |
17 | Ji Y, Liu J, Wang Z, Liu N. Angiotensin II induces inflammatory response partly via Toll-like receptor 4-dependent signaling pathway in vascular smooth muscle cells. Cell Physiol Biochem 2009;23:265-276. DOI |
18 | Lim SW, Li C, Ahn KO, et al. Cyclosporine-induced renal injury induces Toll-like receptor and maturation of dendritic cells. Transplantation 2005;80:691-699. DOI |
19 | Rivera CA, Gaskin L, Allman M, et al. Toll-like receptor-2 deficiency enhances non-alcoholic steatohepatitis. BMC Gastroenterol 2010;10:52. DOI |
20 | Miyake K. Innate immune sensing of pathogens and danger signals by cell surface Toll-like receptors. Semin Immunol 2007;19:3-10. DOI |
21 | West XZ, Malinin NL, Merkulova AA, et al. Oxidative stress induces angiogenesis by activating TLR2 with novel endogenous ligands. Nature 2010;467:972-976. DOI |
22 | Shigeoka AA, Holscher TD, King AJ, et al. TLR2 is constitutively expressed within the kidney and participates in ischemic renal injury through both MyD88-dependent and -independent pathways. J Immunol 2007;178:6252-6258. DOI |
23 | Ahn KO, Lim SW, Li C, et al. Influence of angiotensin II on expression of Toll-like receptor 2 and maturation of dendritic cells in chronic cyclosporine nephropathy. Transplantation 2007;83:938-947. DOI |
24 | Johnson GB, Brunn GJ, Tang AH, Platt JL. Evolutionary clues to the functions of the Toll-like family as surveillance receptors. Trends Immunol 2003;24:19-24. DOI |
25 | Wu WP, Chang CH, Chiu YT, et al. A reduction of unilateral ureteral obstruction-induced renal fibrosis by a therapy combining valsartan with aliskiren. Am J Physiol Renal Physiol 2010;299:F929-F941. DOI |
26 | Yoo KH, Norwood VF, el-Dahr SS, Yosipiv I, Chevalier RL. Regulation of angiotensin II AT1 and AT2 receptors in neonatal ureteral obstruction. Am J Physiol 1997;273(2 Pt 2):R503-R509. |
27 | Yoon HE, Ghee JY, Piao S, et al. Angiotensin II blockade upregulates the expression of Klotho, the anti-ageing gene, in an experimental model of chronic cyclosporine nephropathy. Nephrol Dial Transplant 2011;26:800-813. DOI |
28 | Amann B, Tinzmann R, Angelkort B. ACE inhibitors improve diabetic nephropathy through suppression of renal MCP-1. Diabetes Care 2003;26:2421-2425. DOI |
29 | Wolak T, Kim H, Ren Y, Kim J, Vaziri ND, Nicholas SB. Osteopontin modulates angiotensin II-induced inflammation, oxidative stress, and fibrosis of the kidney. Kidney Int 2009;76:32-43. DOI |
30 | Persy VP, Verhulst A, Ysebaert DK, De Greef KE, De Broe ME. Reduced postischemic macrophage infiltration and interstitial fibrosis in osteopontin knockout mice. Kidney Int 2003;63:543-553. DOI |
31 | Huang Y, Wongamorntham S, Kasting J, et al. Renin increases mesangial cell transforming growth factorbeta1 and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms. Kidney Int 2006;69:105-113. DOI |
![]() |