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http://dx.doi.org/10.3904/kjim.2016.31.1.30

The antibacterial effect of fatty acids on Helicobacter pylori infection  

Jung, Sung Woo (Division of Gastroenterology and Hepatology, Department of Internal Medicine, Korea University College of Medicine)
Lee, Sang Woo (Division of Gastroenterology and Hepatology, Department of Internal Medicine, Korea University College of Medicine)
Publication Information
The Korean journal of internal medicine / v.31, no.1, 2016 , pp. 30-35 More about this Journal
Abstract
Eradication of Helicobacter pylori is recommended for the management of various gastric diseases, including peptic ulcers and mucosa-associated lymphoid tissue lymphoma. Because of the increasing prevalence of antibiotic resistance, the eradication rates of antibiotic-based therapies have decreased. Therefore, alternative treatments should be considered. The antibacterial properties of fatty acids (FAs) have been investigated in various organisms, including H. pylori. Some FAs, particularly polyunsaturated FAs, have been shown to have bactericidal activity against H. pylori in vitro; however, their antibacterial effects in vivo remain controversial. Poor solubility and delivery of FAs may be important reasons for this discrepancy. Recently, a series of studies demonstrated the antibacterial effects of a liposomal formulation of linolenic acid against H. pylori, both in vitro and in vivo. Further research is needed to improve the bioavailability of FAs and apply them in clinical use.
Keywords
Helicobacter pylori; Fatty acids; Anti-bacterial agents; Liposomes; Drug delivery systems;
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1 Correia M, Michel V, Matos AA, et al. Docosahexaenoic acid inhibits Helicobacter pylori growth in vitro and mice gastric mucosa colonization. PLoS One 2012;7:e35072.   DOI
2 Simopoulos AP. Omega-3 fatty acids in inflammation and autoimmune diseases. J Am Coll Nutr 2002;21:495-505.   DOI
3 Calder PC. n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases. Am J Clin Nutr 2006;83(6 Suppl):1505S-1519S.   DOI
4 Kohli P, Levy BD. Resolvins and protectins: mediating solutions to inflammation. Br J Pharmacol 2009;158:960-971.   DOI
5 Zhang MJ, Spite M. Resolvins: anti-inflammatory and proresolving mediators derived from omega-3 polyunsaturated fatty acids. Annu Rev Nutr 2012;32:203-227.   DOI
6 Correia M, Michel V, Osorio H, et al. Crosstalk between Helicobacter pylori and gastric epithelial cells is impaired by docosahexaenoic acid. PLoS One 2013;8:e60657.   DOI
7 Lee SE, Lim JW, Kim JM, Kim H. Anti-inflammatory mechanism of polyunsaturated fatty acids in Helicobacter pylori-infected gastric epithelial cells. Mediators Inflamm 2014;2014:128919.
8 Miller TA. Protective effects of prostaglandins against gastric mucosal damage: current knowledge and proposed mechanisms. Am J Physiol 1983;245(5 Pt 1):G601-G623.
9 Duggan AE, Atherton JC, Cockayne A, et al. Clarification of the link between polyunsaturated fatty acids and Helicobacter pylori-associated duodenal ulcer disease: a dietary intervention study. Br J Nutr 1997;78:515-522.   DOI
10 Frieri G, Pimpo MT, Palombieri A, et al. Polyunsaturated fatty acid dietary supplementation: an adjuvant approach to treatment of Helicobacter pylori infection. Nutr Res 2000;20:907-916.   DOI
11 Yu HN, Zhu J, Pan WS, Shen SR, Shan WG, Das UN. Effects of fish oil with a high content of n-3 polyunsaturated fatty acids on mouse gut microbiota. Arch Med Res 2014;45:195-202.   DOI
12 Pagkalos VA, Moschandreas J, Kiriakakis M, Roussomoustakaki M, Kafatos A, Kouroumalis E. Fatty acid composition of subcutaneous adipose tissue and gastric mucosa: is there a relation with gastric ulceration? BMC Gastroenterol 2009;9:9.   DOI
13 Meier R, Wettstein A, Drewe J, Geiser HR; Swiss Helicobacter-Study Group. Fish oil (Eicosapen) is less effective than metronidazole, in combination with pantoprazole and clarithromycin, for Helicobacter pylori eradication. Aliment Pharmacol Ther 2001;15:851-855.   DOI
14 Khandouzi N, Shidfar F, Agah S, Hosseini AF, Dehnad A. Comparison of the effects of eicosapentaenoic acid and docosahexaenoic acid on the eradication of Helicobacter pylori infection, serum inflammatory factors and total antioxidant capacity. Iran J Pharm Res 2015;14:149-157.
15 Lacey RW, Lord VL. Sensitivity of staphylococci to fatty acids: novel inactivation of linolenic acid by serum. J Med Microbiol 1981;14:41-49.   DOI
16 Dyall SC. Methodological issues and inconsistencies in the field of omega-3 fatty acids research. Prostaglandins Leukot Essent Fatty Acids 2011;85:281-285.   DOI
17 Glassman HN. Surface active agents and their application in bacteriology. Bacteriol Rev 1948;12:105-148.
18 Torchilin VP. Recent advances with liposomes as pharmaceutical carriers. Nat Rev Drug Discov 2005;4:145-160.   DOI
19 Allen TM, Cullis PR. Liposomal drug delivery systems: from concept to clinical applications. Adv Drug Deliv Rev 2013;65:36-48.   DOI
20 Thamphiwatana S, Gao W, Pornpattananangkul D, et al. Phospholipase A2-responsive antibiotic delivery via nanoparticle-stabilized liposomes for the treatment of bacterial infection. J Mater Chem B Mater Biol Med 2014;2:8201-8207.   DOI
21 Suerbaum S, Michetti P. Helicobacter pylori infection. N Engl J Med 2002;347:1175-1186.   DOI
22 Malfertheiner P, Megraud F, O'Morain CA, et al. Management of Helicobacter pylori infection: the Maastricht IV/Florence Consensus Report. Gut 2012;61:646-664.   DOI
23 Graham DY. Roadmap for elimination of gastric cancer in Korea. Korean J Intern Med 2015;30:133-139.   DOI
24 Vakil N, Megraud F. Eradication therapy for Helicobacter pylori. Gastroenterology 2007;133:985-1001.   DOI
25 De Francesco V, Giorgio F, Hassan C, et al. Worldwide H. pylori antibiotic resistance: a systematic review. J Gastrointestin Liver Dis 2010;19:409-414.
26 Bang CS, Baik GH. Time to learn from the past and prepare for the future in Helicobacter pylori eradication. Korean J Intern Med 2015;30:789-791.   DOI
27 Obonyo M, Zhang L, Thamphiwatana S, Pornpattananangkul D, Fu V, Zhang L. Antibacterial activities of liposomal linolenic acids against antibiotic-resistant Helicobacter pylori. Mol Pharm 2012;9:2677-2685.   DOI
28 Jung SW, Thamphiwatana S, Zhang L, Obonyo M. Mechanism of antibacterial activity of liposomal linolenic acid against Helicobacter pylori. PLoS One 2015;10:e0116519.   DOI
29 Thamphiwatana S, Gao W, Obonyo M, Zhang L. In vivo treatment of Helicobacter pylori infection with liposomal linolenic acid reduces colonization and ameliorates inflammation. Proc Natl Acad Sci U S A 2014;111:17600-17605.   DOI
30 Gisbert JP. Rescue therapy for Helicobacter pylori infection 2012. Gastroenterol Res Pract 2012;2012:974594.
31 Chuah SK, Tsay FW, Hsu PI, Wu DC. A new look at anti-Helicobacter pylori therapy. World J Gastroenterol 2011;17:3971-3975.   DOI
32 Kabara JJ, Swieczkowski DM, Conley AJ, Truant JP. Fatty acids and derivatives as antimicrobial agents. Antimicrob Agents Chemother 1972;2:23-28.   DOI
33 Desbois AP, Smith VJ. Antibacterial free fatty acids: activities, mechanisms of action and biotechnological potential. Appl Microbiol Biotechnol 2010;85:1629-1642.   DOI
34 Hazell SL, Markesich DC, Evans DJ, Evans DG, Graham DY. Influence of media supplements on growth and survival of Campylobacter pylori. Eur J Clin Microbiol Infect Dis 1989;8:597-602.   DOI
35 Hazell SL, Graham DY. Unsaturated fatty acids and viability of Helicobacter (Campylobacter) pylori. J Clin Microbiol 1990;28:1060-1061.
36 Thompson L, Cockayne A, Spiller RC. Inhibitory effect of polyunsaturated fatty acids on the growth of Helicobacter pylori: a possible explanation of the effect of diet on peptic ulceration. Gut 1994;35:1557-1561.   DOI
37 Khulusi S, Ahmed HA, Patel P, Mendall MA, Northfield TC. The effects of unsaturated fatty acids on Helicobacter pylori in vitro. J Med Microbiol 1995;42:276-282.   DOI
38 Petschow BW, Batema RP, Ford LL. Susceptibility of Helicobacter pylori to bactericidal properties of medium-chain monoglycerides and free fatty acids. Antimicrob Agents Chemother 1996;40:302-306.
39 Bergsson G, Steingrimsson O, Thormar H. Bactericidal effects of fatty acids and monoglycerides on Helicobacter pylori. Int J Antimicrob Agents 2002;20:258-262.   DOI
40 Sun CQ, O'Connor CJ, Roberton AM. Antibacterial actions of fatty acids and monoglycerides against Helicobacter pylori. FEMS Immunol Med Microbiol 2003;36:9-17.   DOI