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http://dx.doi.org/10.3904/kjim.2013.28.2.206

Is the frequency of metabolic syndrome higher in South Korean women with rheumatoid arthritis than in healthy subjects?  

Lee, Seung-Geun (Department of Internal Medicine, Pusan National University School of Medicine)
Kim, Ji-Min (Department of Internal Medicine, Pusan National University School of Medicine)
Lee, Sun-Hee (Department of Internal Medicine, Pusan National University School of Medicine)
Kim, Kye-Hyung (Department of Internal Medicine, Pusan National University School of Medicine)
Kim, Ji-Hye (Department of Internal Medicine, Pusan National University School of Medicine)
Yi, Ji-Won (Department of Internal Medicine, Pusan National University School of Medicine)
Jung, Woo-Jin (Department of Internal Medicine, Pusan National University School of Medicine)
Park, Young-Eun (Department of Internal Medicine, Malgeunsem Hospital)
Park, Seong-Hu (Department of Internal Medicine, Young Do Hospital)
Lee, Joung-Wook (Department of Internal Medicine, Busan St. Mary's Medical Center)
Baek, Seung-Hoon (Department of Internal Medicine, Ilsin Christian Hospital)
Lee, Jun-Hee (Department of Internal Medicine, Ilsin Christian Hospital)
Kim, Geun-Tae (Division of Rheumatology, Department of Internal Medicine, Kosin University College of Medicine)
Publication Information
The Korean journal of internal medicine / v.28, no.2, 2013 , pp. 206-215 More about this Journal
Abstract
Background/Aims: To compare the frequency of metabolic syndrome (MetS) and magnitude of insulin resistance, measured by the homeostatic model assessment of insulin resistance (HOMA-IR), between South Korean women with rheumatoid arthritis (RA) and healthy subjects, and to evaluate risk factors for MetS and increased HOMA-IR in patients with RA. Methods: In a cross-sectional setting, 84 female patients with RA and 109 agematched healthy female subjects were consecutively recruited at a university-affiliated rheumatology center in South Korea. MetS was defined according to the Third Report of the National Cholesterol Education Program's Adult Treatment Panel (NCEP-ATP III) 2004 criteria. Results: The frequency of MetS did not differ significantly between patients with RA (19%) and healthy subjects (15.6%, p = 0.566), although patients with RA had a higher HOMA-IR compared with healthy subjects (p < 0.001). Patients with RA met the NCEP-ATP III 2004 criteria for high blood pressure more often than healthy subjects (44% vs. 19.3%, p < 0.001), and low high density lipoprotein cholesterol was more prevalent in healthy subjects (33%) than in patients with RA (14.3%, p = 0.004). Although no obvious risk factors for the presence of MetS were identified in patients with RA, higher serum C-reactive protein and disease activity score assessed using the 28-joint count for swelling and tenderness-erythrocyte sedimentation rate significantly contributed to a higher HOMA-IR. Conclusions: Despite their increased insulin resistance, South Korean women with RA did not have a significantly higher frequency of MetS compared with that in healthy subjects.
Keywords
Arthritis, rheumatoid; Metabolic syndrome X; Insulin resistance; Cardiovascular diseases;
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