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http://dx.doi.org/10.3904/kjim.2012.27.1.66

Associations among Body Mass Index, Insulin Resistance, and Pancreatic ${\beta}-Cell$ Function in Korean Patients with New-Onset Type 2 Diabetes  

Chung, Jin-Ook (Division of Endocrinology and Metabolism, Department of Internal Medicine, Chonnam National University Medical School)
Cho, Dong-Hyeok (Division of Endocrinology and Metabolism, Department of Internal Medicine, Chonnam National University Medical School)
Chung, Dong-Jin (Division of Endocrinology and Metabolism, Department of Internal Medicine, Chonnam National University Medical School)
Chung, Min-Young (Division of Endocrinology and Metabolism, Department of Internal Medicine, Chonnam National University Medical School)
Publication Information
The Korean journal of internal medicine / v.27, no.1, 2012 , pp. 66-71 More about this Journal
Abstract
Background/Aims: We investigated the associations among body mass index (BMI), insulin resistance, and ${\beta}-Cell$ function in Korean patients newly presenting with type 2 diabetes. Methods: In total, 132 patients with new-onset type 2 diabetes mellitus were investigated. A standard 75-g oral glucose tolerance test was performed, and the indices of insulin secretion and insulin resistance were calculated. Results: A higher BMI was associated with higher homeostasis model assessment values for insulin resistance (HOMAIR), homeostasis model assessment of ${\beta}-Cell$ function ($HOMA-{\beta}$), and insulinogenic index as well as lower levels of insulin sensitivity index composite ($ISI_{comp}$) and disposition index (DI). In multiple regression models, BMI had independent positive associations with HOMA-IR, $ISI_{comp}$, and $HOMA-{\beta}$ and inverse associations with the DI. Conclusions: Our results showed that BMI had independent positive associations with indices of insulin resistance and an inverse association with ${\beta}-Cell$ function adjusted for insulin resistance in Korean patients newly presenting with type 2 diabetes.
Keywords
Body mass index; Insulin resistance; Secretion; Diabetes mellitus, type 2;
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