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http://dx.doi.org/10.3904/kjim.2011.26.1.8

Prostaglandin $D_2$ and $T_H2$ Inflammation in the Pathogenesis of Bronchial Asthma  

Arima, Masafumi (Department of Developmental Genetics (H2), Chiba University Graduate School of Medicine)
Fukuda, Takeshi (Department of Pulmonary Medicine and Clinical Immunology, Dokkyo University School of Medicine)
Publication Information
The Korean journal of internal medicine / v.26, no.1, 2011 , pp. 8-18 More about this Journal
Abstract
Prostaglandin D_2$ ($PGD_2$) is a major prostanoid, produced mainly by mast cells, in allergic diseases, including bronchial asthma. $PGD_2$-induced vasodilatation and increased permeability are well-known classical effects that may be involved in allergic inflammation. Recently, novel functions of $PGD_2$ have been identified. To date, D prostanoid receptor (DP) and chemoattractant receptor homologous molecule expressed on $T_H2$ cells (CRTH2) have been shown to be major $PGD_2$-related receptors. These two receptors have pivotal roles mediating allergic diseases by regulating the functions of various cell types, such as $T_H2$ cells, eosinophils, basophils, mast cells, dendritic cells, and epithelial cells. This review will focus on the current understanding of the roles of $PGD_2$ and its metabolites in $T_H2$ inflammation and the pathogenesis of bronchial asthma.
Keywords
Basophils; Asthma; Eosinophils; Mast cells; Prostaglandins; $T_H2$ cells;
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