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Sugawara, Akira
(Department of Advanced Biological Sciences for Regeneration, Tohoku University Graduate School of Medicine)
Uruno, Akira (Department of Medical Biochemistry, Tohoku University Graduate School of Medicine) Kudo, Masataka (Department of Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine) Matsuda, Ken (Department of Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine) Yang, Chul-Woo (Division of Nephrology, Department of Internal Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea School of Medicine) Ito, Sadayoshi (Department of Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine) |
1 |
Sugawara A, Uruno A, Kudo M, Matsuda K, Yang CW, Ito S. Effects of PPAR |
2 | Sarafidis PA, Lasaridis AN. Actions of peroxisome proliferatoractivated receptors-gamma agonists explaining a possible blood pressure-lowering effect. Am J Hypertens 2006;19:646-653. DOI ScienceOn |
3 | Dormandy JA, Charbonnel B, Eckland DJ, et al. Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomized controlled trial. Lancet 2005;366:1279-1289. DOI ScienceOn |
4 | Sugawara A, Takeuchi K, Uruno A, et al. Transcriptional suppression of type 1 angiotensin II receptor gene expression by peroxisome proliferator-activated receptor-gamma in vascular smooth muscle cells. Endocrinology 2001;142:3125-3134. DOI ScienceOn |
5 | Sugawara A, Takeuchi K, Uruno A, et al. Differential effects among thiazolidinediones on the transcription of thromboxane receptor and angiotensin II type 1 receptor genes. Hypertens Res 2001;24:229-233. DOI ScienceOn |
6 | Sugawara A, Takeuchi K, Uruno A, Kudo M, Sato K, Ito S. Effects of mitogen-activated protein kinase pathway and co-activator CREP-binding protein on peroxisome proliferator-activated receptor-gamma-mediated transcription suppression of angiotensin II type 1 receptor gene. Hypertens Res 2003;26:623-628. DOI ScienceOn |
7 | Diep QN, El Mabrouk M, Cohn JS, et al. Structure, endothelial function, cell growth, and inflammation in blood vessels of angiotensin II-infused rats: role of peroxisome proliferator-activated receptor-gamma. Circulation 2002;105:2296-2302. DOI ScienceOn |
8 | Benkirane K, Viel EC, Amiri F, Schiffrin EL. Peroxisome proliferator-activated receptor gamma regulates angiotensin II-stimulated phosphatidylinositol 3-kinase and mitogen-activated protein kinase in blood vessels in vivo. Hypertension 2006;47:102-108. DOI |
9 | Ji Y, Liu J, Wang Z, Liu N, Gou W. PPARgamma agonist, rosiglitazone, regulates angiotensin II-induced vascular inflammation through the TLR4-dependent signaling pathway. Lab Invest 2009;89:887-902. DOI ScienceOn |
10 | Uruno A, Matsuda K, Noguchi N, et al. Peroxisome proliferatoractivated receptor-{gamma} suppresses CYP11B2 expression and aldosterone production. J Mol Endocrinol 2011;46:37-49. DOI ScienceOn |
11 | Wu L, Wang R, De Champlain J, Wilson TW. Beneficial and deleterious effects of rosiglitazone on hypertension development in spontaneously hypertensive rats. Am J Hypertens 2004;17:749-756. DOI ScienceOn |
12 | Iglarz M, Touyz RM, Amiri F, Lavoie MF, Diep QN, Schiffrin EL. Effect of peroxisome proliferator-activated receptor-alpha and -gamma activators on vascular remodeling in endothelin-dependent hypertension. Arterioscler Thromb Vasc Biol 2003;23:45-51. DOI ScienceOn |
13 | Ryan MJ, Didion SP, Mathur S, Faraci FM, Sigmund CD. PPAR(gamma) agonist rosiglitazone improves vascular function and lowers blood pressure in hypertensive transgenic mice. Hypertension 2004;43:661-666. DOI ScienceOn |
14 | Tsai YS, Kim HJ, Takahashi N, et al. Hypertension and abnormal fat distribution but not insulin resistance in mice with P465L PPARgamma. J Clin Invest 2004;114:240-249. DOI |
15 | Barroso I, Gurnell M, Crowley VE, et al. Dominant negative mutations in human PPARgamma associated with severe insulin resistance, diabetes mellitus and hypertension. Nature 1999;402:880-883. DOI |
16 | Majithiya JB, Paramar AN, Balaraman R. Pioglitazone, a PPARgamma agonist, restores endothelial function in aorta of streptozotocin-induced diabetic rats. Cardiovasc Res 2005;66:150-161. DOI ScienceOn |
17 | Tsai YS, Xu L, Smithies O, Maeda N. Genetic variations in peroxisome proliferator-activated receptor gamma expression affect blood pressure. Proc Natl Acad Sci U S A 2009;106:19084-19089. DOI ScienceOn |
18 | Ikeda Y, Sugawara A, Taniyama Y, et al. Suppression of rat thromboxane synthase gene transcription by peroxisome proliferator- activated receptor gamma in macrophages via an interaction with NRF2. J Biol Chem 2000;275:33142-33150. DOI ScienceOn |
19 | Sugawara A, Uruno A, Kudo M, et al. Transcription suppression of thromboxane receptor gene by peroxisome proliferator-activated receptor-gamma via an interaction with Sp1 in vascular smooth muscle cells. J Biol Chem 2002;277:9676-9683. DOI ScienceOn |
20 | Miike T, Kunishiro K, Kanda M, Azukizawa S, Kurahashi K, Shirahase H. Impairment of endothelium-dependent AChinduced relaxation in aorta of diabetic db/db mice: possible dysfunction of receptor and/or receptor-G protein coupling. Naunyn Schmiedebergs Arch Pharmacol 2008;377:401-410. DOI ScienceOn |
21 | Martens FM, Visseren FL, de Koning EJ, Rabelink TJ. Shortterm pioglitazone treatment improves vascular function irrespective of metabolic changes in patients with type 2 diabetes. J Cardiovasc Pharmacol 2005;46:773-778. DOI ScienceOn |
22 | Staniloae C, Mandadi V, Kurian D, et al. Pioglitazone improves endothelial function in non-diabetic patients with coronary artery disease. Cardiology 2007;108:164-169. DOI ScienceOn |
23 | Beyer AM, de Lange WJ, Halabi CM, et al. Endothelium-specific interference with peroxisome proliferator activated receptor gamma causes cerebral vascular dysfunction in response to a high-fat diet. Circ Res 2008;103:654-661. DOI ScienceOn |
24 | Webb DR, Davies MJ, Gray LJ, et al. Searching for the right outcome? A systematic review and meta-analysis of controlled trials using carotid intima-media thickness or pulse wave velocity to infer antiatherogenic properties of thiazolidinediones. Diabetes Obes Metab 2010;12:124-132. DOI ScienceOn |
25 | Marx N, Walcher D. Vascular effects of PPARgamma activators: from bench to bedside. Prog Lipid Res 2007;46:283-296. DOI ScienceOn |
26 | Lim S, Jin CJ, Kim M, et al. PPARgamma gene transfer sustains apoptosis, inhibits vascular smooth muscle cell proliferation, and reduces neointima formation after balloon injury in rats. Arterioscler Thromb Vasc Biol 2006;26:808-813. DOI ScienceOn |
27 | Joner M, Farb A, Cheng Q, et al. Pioglitazone inhibits in-stent restenosis in atherosclerotic rabbits by targeting transforming growth factor-beta and MCP-1. Arterioscler Thromb Vasc Biol 2007;27:182-189. DOI ScienceOn |
28 | Kudo M, Sugawara A, Saito A, Uruno A, Ito S. Effects of pioglitazone, belaprost, and fluvastatin on gene expression in vascular endothelial cells revealed by DNA microarray analyses. J Hypertens 2006;24 Suppl 6:238. |
29 | Polikandriotis JA, Mazzella LJ, Rupnow HL, Hart CM. Peroxisome proliferator-activated receptor gamma ligands stimulate endothelial nitric oxide production through distinct peroxisome proliferator-activated receptor gamma-dependent mechanisms. Arterioscler Thromb Vasc Biol 2005;25:1810-1816. DOI ScienceOn |
30 | Werner C, Kamani CH, Gensch C, Bohm M, Laufs U. The peroxisome proliferator-activated receptor-gamma agonist pioglitazone increases number and function of endothelial progenitor cells in patients with coronary artery disease and normal glucose tolerance. Diabetes 2007;56:2609-2615. DOI ScienceOn |
31 | Arima S, Kohagura K, Takeuchi K, et al. Biphasic vasodilator action of troglitazone on the renal microcirculation. J Am Soc Nephrol 2002;13:342-349. |
32 | Kleinhenz JM, Kleinhenz DJ, You S, et al. Disruption of endothelial peroxisome proliferator-activated receptor-gamma reduces vascular nitric oxide production. Am J Physiol Heart Circ Physiol 2009;297:H1647-H1654. DOI ScienceOn |
33 | Sato K, Sugawara A, Kudo M, Uruno A, Ito S, Takeuchi K. Expression of peroxisome proliferator-activated receptor isoform proteins in the rat kidney. Hypertens Res 2004;27:417-425. DOI ScienceOn |
34 | Ahn KO, Lim SW, Yang HJ, et al. Induction of PPAR gamma mRNA and protein expression by rosiglitazone in chronic cyclosporine nephropathy in the rat. Yonsei Med J 2007;48:308-316. DOI ScienceOn |
35 | Guan Y, Hao C, Cha DR, et al. Thiazolidinediones expand body fluid volume through PPARgamma stimulation of ENaC-mediated renal salt absorption. Nat Med 2005;11:861-866. DOI ScienceOn |
36 | Yang J, Zhang D, Li J, Zhang X, Fan F, Guan Y. Role of PPARgamma in renoprotection in type 2 diabetes: molecular mechanisms and therapeutic potential. Clin Sci (Lond) 2009;116:17-26. DOI ScienceOn |
37 | Sarafidis PA, Stafylas PC, Georgianos PI, Saratzis AN, Lasaridis AN. Effect of thiazolidinediones on albuminuria and proteinuria in diabetes: a meta-analysis. Am J Kidney Dis 2010;55:835-847. DOI ScienceOn |
38 | Chung BH, Lim SW, Ahn KO, et al. Protective effect of peroxisome proliferator activated receptor gamma agonists on diabetic and non-diabetic renal diseases. Nephrology (Carlton) 2005;10 Suppl:S40-S43. DOI |
39 | Chung BH, Li C, Sun BK, et al. Rosiglitazone protects against cyclosporine-induced pancreatic and renal injury in rats. Am J Transplant 2005;5:1856-1867. DOI ScienceOn |
40 | Yang HC, Deleuze S, Zuo Y, Potthoff SA, Ma LJ, Fogo AB. The PPARgamma agonist pioglitazone ameliorates aging-related progressive renal injury. J Am Soc Nephrol 2009;20:2380-2388. DOI ScienceOn |
41 | Blanquicett C, Roman J, Hart CM. Thiazolidinediones as anticancer agents. Cancer Ther 2008;6:25-34. |
42 | Yamauchi A, Takahashi I, Takasawa S, et al. Thiazolidinediones inhibit REG Ialpha gene transcription in gastrointestinal cancer cells. Biochem Biophys Res Commun 2009;379:743-748. DOI ScienceOn |
43 | Kliewer SA, Xu HE, Lambert MH, Willson TM. Peroxisome proliferator- activated receptors: from genes to physiology. Recent Prog Horm Res 2001;56:239-263. DOI ScienceOn |
44 | Marchesi C, Schiffrin EL. Peroxisome proliferator-activated receptors and the vascular system: beyond their metabolic effects. J Am Soc Hypertens 2008;2:227-238. DOI ScienceOn |
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