Browse > Article
http://dx.doi.org/10.3904/kjm.2014.87.5.625

Glucocorticoid Triggers an Attack of Periodic Hypokalemic Paralysis during Treatment for Diffuse Large B-cell Lymphoma  

Ha, Kyung Sun (Department of Internal Medicine, The Catholic University College of Medicine)
Park, Young Jae (Department of Internal Medicine, The Catholic University College of Medicine)
Park, Sung Soo (Department of Internal Medicine, The Catholic University College of Medicine)
Lee, Joon Yub (Department of Internal Medicine, The Catholic University College of Medicine)
Kim, Ji Hyun (Department of Internal Medicine, The Catholic University College of Medicine)
Jang, Inae (Department of Internal Medicine, The Catholic University College of Medicine)
Byun, Jae Ho (Department of Internal Medicine, The Catholic University College of Medicine)
Publication Information
The Korean Journal of Medicine / v.87, no.5, 2014 , pp. 625-629 More about this Journal
Abstract
Hypokalemic periodic paralysis is a rare disorder characterized by sudden onset of weakness and low serum potassium levels. We report a case provoked by combination chemotherapy including prednisolone. A 23-yr-man, diagnosed with diffuse large B-cell lymphoma, received chemotherapy. He developed significant weakness in upper and lower extremities during chemotherapy, and his serum potassium level was 1.7 mmol/L. Potassium replacement restored the weakness. Further workup revealed that prednisolone had provoked hypokalemic paralysis. As prednisolone triggered an attack of hypokalemic periodic paralysis, it should be administered with caution, particularly in patients with periodic paralysis.
Keywords
Hypokalemic Periodic Paralysis; Diffuse large B-cell lymphoma;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Streeten DH, Speller PJ, Fellerman H. Use of corticotropin- induced potassium changes in the diagnosis of both hypo- and hyperkalemic periodic paralysis. Eur Neurol 1993;33:103-108.   DOI
2 Brillon DJ, Zheng B, Campbell RG, Matthews DE. Effect of cortisol on energy expenditure and amino acid metabolism in humans. Am J Physiol 1995;268:E501-513.
3 Tassone H, Moulin A, Henderson SO. The pitfalls of potassium replacement in thyrotoxic periodic paralysis: a case report and review of the literature. J Emerg Med 2004;26:157-161.   DOI   ScienceOn
4 Ikeda K, Iwasaki Y, Kinoshita M, et al. Acetazolamide- induced muscle weakness in hypokalemic periodic paralysis. Intern Med 2002;41:743-745.   DOI
5 Arzel-Hezode M, McGoey S, Sternberg D, Vicart S, Eymard B, Fontaine B. Glucocorticoids may trigger attacks in several types of periodic paralysis. Neuromuscul Disord 2009;19:217-219.   DOI   ScienceOn
6 Miyashita Y, Monden T, Yamamoto K, et al. Ventricular fibrillation due to severe hypokalemia induced by steroid treatment in a patient with thyrotoxic periodic paralysis. Intern Med 2006;45:11-13.   DOI
7 Finsterer J. Primary periodic paralyses. Acta Neurol Scand 2008;117:145-158.   DOI   ScienceOn
8 Fontaine B, Fournier E, Sternberg D, Vicart S, Tabti N. Hypokalemic periodic paralysis: a model for a clinical and research approach to a rare disorder. Neurotherapeutics 2007;4:225-232.   DOI   ScienceOn
9 Wongraoprasert S, Buranasupkajorn P, Sridama V, Snabboon T. Thyrotoxic periodic paralysis induced by pulse methylprednisolone. Intern Med 2007;46:1431-1433.   DOI
10 Sternberg D, Tabti N, Hainque B, Fontaine B. Hypokalemic Periodic Paralysis. In: Pagon RA, Adam MP, Bird TD, Dolan CR, Fong CT, Stephens K, eds. GeneReviews R[Internet]. Seattle(WA): University of Washington, 2002