Browse > Article
http://dx.doi.org/10.3904/kjm.2014.87.5.603

Case of Successful Radiofrequency Ablation of Multiple Bilateral Renal Cell Carcinomas in von Hippel-Lindau Disease  

Moon, Sang Yi (Departments of Internal Medicine, College of Medicine, Dong-A University)
Kim, Dong Hyun (Departments of Internal Medicine, College of Medicine, Dong-A University)
Jung, Eui Han (Departments of Internal Medicine, College of Medicine, Dong-A University)
Park, So Young (Departments of Internal Medicine, College of Medicine, Dong-A University)
Park, Mi Kyung (Departments of Internal Medicine, College of Medicine, Dong-A University)
Kim, Duk Kyu (Departments of Internal Medicine, College of Medicine, Dong-A University)
Suh, Sunghwan (Departments of Internal Medicine, College of Medicine, Dong-A University)
Publication Information
The Korean Journal of Medicine / v.87, no.5, 2014 , pp. 603-608 More about this Journal
Abstract
Von Hippel-Lindau (VHL) disease is an inherited, autosomal dominant syndrome that manifests as a variety of benign and malignant tumors in various organs. Notably, renal cell carcinoma (RCC) in patients with VHL disease tends to be multifocal and bilateral, and tends to recur or new tumors develop after removal. Radiofrequency ablation (RFA) has recently been introduced as a minimally invasive treatment for small hereditary RCCs with a low complication rate and a minimal decrease in renal function. We present a case of successful RFA of multiple bilateral RCCs in a 24-year-old female with VHL. Computed tomography (CT) of the abdomen revealed multiple bilateral RCCs. The patient received sequential RFA for the bilateral RCCs, resulting in a complete response. At the time of writing, there was no sign of recurrence or renal failure. In conclusion, percutaneous RFA is a promising treatment for VHL patients who cannot undergo surgery, with excellent treatment outcomes and minimal change in renal function.
Keywords
von Hippel Lindau Disease; Renal cell carcinoma; Ablation;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Maher ER, Yates JR, Harries R, et al. Clinical features and natural history of von Hippel-Lindau disease. Q J Med 1990;77:1151-1163.   DOI   ScienceOn
2 Park BK, Kim CK, Park SY, Shen SH. Percutaneous radiofrequency ablation of renal cell carcinomas in patients with von Hippel Lindau disease: indications, techniques, complications, and outcomes. Acta Radiol 2013;54:418-427.   DOI   ScienceOn
3 Zagoria RJ, Traver MA, Werle DM, Perini M, Hayasaka S, Clark PE. Oncologic efficacy of CT-guided percutaneous radiofrequency ablation of renal cell carcinoma. AJR Am J Roentgenol 2007;189:429-436.   DOI   ScienceOn
4 Goldberg SN, Gazelle GS, Mueller PR. Thermal ablation therapy for focal malignancy: a unified approach to underlying principles, techniques, and diagnostic imaging guidance. AJR Am J Roentgenol 2000;174:323-331.   DOI   ScienceOn
5 Wolf JS Jr, Seifman BD, Montie JE. Nephron sparing surgery for suspected malignancy: open surgery compared to laparoscopy with selective use of hand assistance. J Urol 2000;163:1659-1664.   DOI   ScienceOn
6 Bratslavsky G, Liu JJ, Johnson AD, et al. Salvage partial nephrectomy for hereditary renal cancer: feasibility and outcomes. J Urol 2008;179:67-70.
7 Lucas SM, Stern JM, Adibi M, Zeltser IS, Cadeddu JA, Raj GV. Renal function outcomes in patients treated for renal masses smaller than 4 cm by ablative and extirpative techniques. J Urol 2008;179:75-79.
8 Kim JH, Kim TH, Kim SD, Lee KS, Sung GT. Radiofrequency ablation of renal tumors: our experience. Korean J Urol 2011;52:531-537.   DOI   ScienceOn
9 Pasticier G, Timsit MO, Badet L, et al. Nephron-sparing surgery for renal cell carcinoma: detailed analysis of complications over a 15-year period. Eur Urol 2006;49:485-490.   DOI   ScienceOn
10 Ploussard G, Droupy S, Ferlicot S, et al. Local recurrence after nephron-sparing surgery in von Hippel-Lindau disease. Urology 2007;70:435-439.   DOI   ScienceOn