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http://dx.doi.org/10.3904/kjm.2014.87.4.491

A Case of Acute Tubular Necrosis and Hearing Loss Induced by Intravenous Administration of Ciprofloxacin  

Kim, Jun Jae (Department of Internal Medicine, Sanggye Paik Hospital, Inje University College of Medicine)
Kim, Hyun-Jung (Department of Pathology, Sanggye Paik Hospital, Inje University College of Medicine)
Kim, Sang Hyun (Department of Internal Medicine, Sanggye Paik Hospital, Inje University College of Medicine)
Park, Won Do (Department of Internal Medicine, Sanggye Paik Hospital, Inje University College of Medicine)
Publication Information
The Korean Journal of Medicine / v.87, no.4, 2014 , pp. 491-495 More about this Journal
Abstract
Ciprofloxacin is a broad-spectrum antibiotic used to treat a variety of infections. However, acute kidney injury is a rarely reported side effect. Ciprofloxacin-related nephrotoxicity typically manifests as acute tubulointerstitial nephritis. To the best of our knowledge, few cases of acute tubular necrosis as a complication of ciprofloxacin have been reported to date. We herein describe a case involving a 41-year-old woman treated with intravenous ciprofloxacin at 200 mg twice daily for gastroenteritis. One day after initiation of treatment, her serum creatinine level increased from 0.95 to 3.83 mg/dL and she experienced impaired hearing. Five days later, renal biopsy demonstrated acute tubular necrosis. The acute tubular necrosis encountered in this patient resolved; however, short-term hemodialysis was required. This is the first reported case of acute kidney injury associated with ciprofloxacin use in Korea.
Keywords
Ciprofloxacin; Acute kidney injury; Acute Tubular Necrosis; Hearing loss;
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