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http://dx.doi.org/10.3904/kjm.2014.86.6.710

Analysis of Drugs Causing Severe Cutaneous Adverse Reactions, Based on the Korean Database of Spontaneously Reported Adverse Drug Reactions  

Kim, Mi-Yeong (Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center)
Yang, Min-Suk (Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center)
Kang, Hye-Ryun (Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center)
Cho, Sang-Heon (Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center)
Min, Kyung-Up (Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center)
Publication Information
The Korean Journal of Medicine / v.86, no.6, 2014 , pp. 710-721 More about this Journal
Abstract
Background/Aims: Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reaction with eosinophilia and systemic symptoms (DRESS) are severe cutaneous adverse reactions (SCARs) that also affect the internal organs with high mortality. However, there has been no previous nationwide study of SCARs in Korea. Methods: Cases of SCARs were recruited from the nationwide Korean Pharmacovigilance Research Network database, collected from June 2009 to December 2010, by a spontaneous reporting system. We analyzed age, gender, route of administration and the causative agents. We also reviewed previously published cases of SCARs in Korea. Results: In total, 100 cases of SJS (66 cases), TEN (7 cases), and DRESS (27 cases) were reported. The mean age of the patients was $54.1{\pm}19.8$ years and the proportion of males to females was 1:0.88. In total, 81 drugs were reported as causative agents: SJS (61 drugs), TEN (15 drugs), and DRESS (29 drugs). The most commonly reported causative drug was allopurinol (12 cases). Allopurinol (8 cases) and levofloxacin (2 cases) were the most commonly reported causative drugs for SJS and TEN, respectively. In DRESS, allopurinol (4 cases) and vancomycin (4 cases) were the two most common causative drugs. Anti-infective drugs were the most common drug category (75 cases). Carbamazepine was the most commonly reported causative drug according to published cases in Korea. Conclusions: Allopurinol in the spontaneous reporting system and carbamazepine in the published cases were the most common single causative drugs in SCARs in Korea. Anti-infectives were the most common drug category in the spontaneous reporting system.
Keywords
Stevens-Johnson syndrome; Pharmacovigilance; Drug hypersensitivity; Eosinophilia;
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Times Cited By KSCI : 7  (Citation Analysis)
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