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http://dx.doi.org/10.3904/kjm.2014.86.4.442

Role of Ammonia Transporters in the Kidney with Ureteral Obstruction  

Han, Ki-Hwan (Department of Anatomy, Ewha Womans University School of Medicine)
Publication Information
The Korean Journal of Medicine / v.86, no.4, 2014 , pp. 442-443 More about this Journal
Abstract
Recent studies have identified a new family of ammonia transporters, Rh B glycoprotein (Rhbg) and Rh C glycoprotein (Rhcg). Rhbg and Rhcg are expressed in the collecting duct system of the kidney. Although it remains controversial whether Rhbg contributes to renal ammonia transport, Rhcg expression parallels ammonia excretion in a variety of experimental models. Kim et al. made an animal model of unilateral ureteral obstruction and demonstrated a decrease in urinary ammonia excretion. Immunohistochemistry with quantitative morphometric analysis revealed that total intensity of Rhcg expression significantly decreased in the obstructed kidney, but did not change in the non-obstructed kidney. These results suggest that decreased Rhcg is likely to cause for the impaired renal ammonia excretion in unilateral ureteral obstruction.
Keywords
Ammonia; Collecting duct; Ureteral obstruction;
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Times Cited By KSCI : 1  (Citation Analysis)
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1 Han KH, Kim HY, Weiner ID. Expression of rh glycoproteins in the Mammalian kidney. Electrolyte Blood Press 2009;7:14-19.   DOI   ScienceOn
2 Marini AM, Matassi G, Raynal V, Andre B, Cartron JP, Cherif-Zahar B. The human Rhesus-associated RhAG protein and a kidney homologue promote ammonium transport in yeast. Nat Genet 2000;26:341-344.   DOI   ScienceOn
3 Eladari D, Cheval L, Quentin F, et al. Expression of RhCG, a new putative NH(3)/NH(4)(+) transporter, along the rat nephron. J Am Soc Nephrol 2002;13:1999-2008.   DOI   ScienceOn
4 Han KH, Croker BP, Clapp WL, et al. Expression of the ammonia transporter, rh C glycoprotein, in normal and neoplastic human kidney. J Am Soc Nephrol 2006;17:2670-2679.   DOI   ScienceOn
5 Han KH, Lee HW, Handlogten ME, et al. Expression of the ammonia transporter family member, Rh B Glycoprotein, in the human kidney. Am J Physiol Renal Physiol 2013;304:F972-981.   DOI   ScienceOn
6 Weiner ID, Verlander JW. Role of NH3 and NH4+ transporters in renal acid-base transport. Am J Physiol Renal Physiol 2011;300:F11-23.   DOI   ScienceOn
7 Khademi S, O'Connell J 3rd, Remis J, Robles-Colmenares Y, Miercke LJ, Stroud RM. Mechanism of ammonia transport by Amt/MEP/Rh: structure of AmtB at 1.35 A. Science 2004;305:1587-1594.   DOI   ScienceOn
8 Biver S, Belge H, Bourgeois S, et al. A role for Rhesus factor Rhcg in renal ammonium excretion and male fertility. Nature 2008;456:339-343.   DOI   ScienceOn
9 Kim SJ, Kim HY, Choi JH, et al. Renal expression of ammonia transporter in rat with unilateral ureteral obstruction. Korean J Med 2014;86:444-452.   DOI
10 Han KH. Mechanisms of the effects of acidosis and hypokalemia on renal ammonia metabolism. Electrolyte Blood Press 2011;9:45-49.   DOI