Browse > Article
http://dx.doi.org/10.3904/kjm.2014.86.1.89

A Case of Cerebellopontine Angle Diffuse Large B Cell Lymphoma in a Systemic Lupus Erythematosus Patient  

Bae, Soo Hyun (Department of Internal Medicine, Daegu Fatima Hospital)
Kwon, Moon Hyuk (Department of Internal Medicine, Daegu Fatima Hospital)
Kim, Min Hee (Department of Internal Medicine, Daegu Fatima Hospital)
Lee, Sang Ah (Department of Internal Medicine, Daegu Fatima Hospital)
Lee, Jung Lim (Department of Internal Medicine, Daegu Fatima Hospital)
Han, Man Hun (Department of Pathology, Daegu Fatima Hospital)
Yun, Sang Mo (Department of Therapeutic Radiology, Daegu Fatima Hospital)
Publication Information
The Korean Journal of Medicine / v.86, no.1, 2014 , pp. 89-95 More about this Journal
Abstract
Patients with systemic lupus erythematosus (SLE) are at higher risk for malignant lymphomas, among which, however, primary CNS lymphoma (PCNSL) is rare. PCNSL usually occurs within the cerebral hemispheres, occasionally in the cerebellum, but rarely in the cerebellopontine angle (CPA). We report our findings in a 45-year-old man with SLE on azathioprine, who presented with sudden hearing loss and dysphagia. The brain MRI revealed a mass lesion in the right CPA. A biopsy was performed and the final diagnosis was diffuse large B cell lymphoma. This is the first report of CPA lymphoma in a SLE patient. The patient was treated with whole brain radiotherapy only because of recurrent pneumonia that was a result of dysphagia from permanent cranial nerve injury. He has been in complete remission for over 10 months.
Keywords
Diffuse large B cell lymphoma; Systemic lupus erythematosus; Hearing loss;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Pisoni CN, Grinberg AR, Plana JL, Freue RD, Manni JA, Paz L. Primary central nervous system lymphoma in a patient with systemic lupus erythematosus. Medicina (B Aires) 2003;63:221-223.
2 Woolf AS, Conway G. Systemic lupus erythematosus and primary cerebral lymphoma. Postgrad Med J 1987;63:569-571.   DOI
3 Cras P, Franckx C, Martin JJ. Primary intracerebral lymphoma in systemic lupus erythematosus treated with immunosuppressives. Clin Neuropathol 1989;8:200-205.
4 Tomabechi M, Daita G, Ohgami S, Yonemasu Y, Maekawa I. A case of primary intracerebral malignant lymphoma in systemic lupus erythematosus. No Shinkei Geka 1992;20:429-432.
5 Dasgupta N, Gelber AC, Racke F, Fine DM. Central nervous system lymphoma associated with mycophenolate mofetil in lupus nephritis. Lupus 2005;14:910-913.   DOI
6 Finelli PF, Naik K, DiGiuseppe JA, Prasad A. Primary lymphoma of CNS, mycophenolate mofetil and lupus. Lupus 2006;15:886-888.   DOI
7 Biasiotta A, Frati A, Salvati M, et al. Primary hypothalamic lymphoma in a patient with systemic lupus erythematosus: case report and review of the literature. Neurol Sci 2010;31:647-652.   DOI
8 Tsang HH, Trendell-Smith NJ, Wu AK, Mok MY. Diffuse large B-cell lymphoma of the central nervous system in mycophenolate mofetil-treated patients with systemic lupus erythematosus. Lupus 2010;19:330-333.   DOI   ScienceOn
9 Sacho RH, Kogels M, du Plessis D, Jowitt S, Josan VA. Primary diffuse large B-cell central nervous system lymphoma presenting as an acute space-occupying subdural mass. J Neurosurg 2010;113:384-387.   DOI   ScienceOn
10 Svobodova B, Hruskova Z, Rysava R, Tesar V. Brain diffuse large B-cell lymphoma in a systemic lupus erythematosus patient treated with immunosuppressive agents including mycophenolate mofetil. Lupus 2011;20:1452-1454.   DOI   ScienceOn