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http://dx.doi.org/10.3904/kjm.2014.86.1.84

A Case of Different Organ Responses to Immunosuppressive Therapy In a Microscopic Polyangiitis Patient with Interstitial Lung Disease  

Lee, Jae Joon (Division of Nephrology, Department of Internal Medicine, Eulji University Hospital)
Shin, Jong Ho (Division of Nephrology, Department of Internal Medicine, Eulji University Hospital)
Bang, Ki Tae (Division of Nephrology, Department of Internal Medicine, Eulji University Hospital)
Choi, Ji Wook (Division of Nephrology, Department of Internal Medicine, Eulji University Hospital)
Moon, Hyun Jin (Division of Nephrology, Department of Internal Medicine, Eulji University Hospital)
Jeon, Jae Woong (Division of Nephrology, Department of Internal Medicine, Eulji University Hospital)
Jeong, Jin Uk (Division of Nephrology, Department of Internal Medicine, Eulji University Hospital)
Publication Information
The Korean Journal of Medicine / v.86, no.1, 2014 , pp. 84-88 More about this Journal
Abstract
Microscopic polyangiitis (MPA) is an idiopathic autoimmune disease characterized by systemic vasculitis associated with antineutrophil cytoplasmic autoantibodies. Interstitial lung disease is a less recognized manifestation of MPA and has a poor prognosis. A 61-year-old man presented with persistent cough, sputum and dyspnea. Laboratory examination revealed microscopic hematuria and renal insufficiency. Perinuclear anti-neutrophil cytoplasmic autoantibodies were positive according to serological testing. Computed tomography scans showed bibasilar reticulation and honeycombing in a peripheral distribution. Therefore, renal biopsy was performed, and MPA was diagnosed. After treating with corticosteroids and immunosuppressive agents, the patient had a complete renal response but progressive interstitial lung disease. We report a case of MPA presenting with interstitial lung disease in which the patient experienced different responses in each organ.
Keywords
Microscopic polyangiitis; Interstitial lung disease; Anti-neutrophil cytoplasmic antibody-associated vasculitis;
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