Browse > Article
http://dx.doi.org/10.3904/kjm.2013.85.3.329

A Case of Thymoma with Immunodeficiency (Good's Syndrome) with Disseminated Tuberculosis  

Jung, Hyeon (Division of Infectious Diseases, Chungnam National University Hospital)
Sohn, Kyung Mok (Division of Infectious Diseases, Chungnam National University Hospital)
Kim, Yeon-Sook (Division of Infectious Diseases, Chungnam National University Hospital)
Song, Chang Hun (Division of Infectious Diseases, Chungnam National University Hospital)
Sohn, Eun Hee (Department of Neurology, Chungnam National University Hospital)
Publication Information
The Korean Journal of Medicine / v.85, no.3, 2013 , pp. 329-333 More about this Journal
Abstract
Good's syndrome is the rare association of immunodeficiency with thymoma, characterized by hypogammaglobulinemia, depleted B-cells, diminished T-cells and inversion of the CD4/CD8 ratio. Thymectomy does not usually improve hypogammaglobulinemia; thus, the patient remains prone to infections. Infections affect primarily the sinopulmonary and gastrointestinal system. Here we present a case of a 71-year-old woman with common manifestations of Good's syndrome who succumbed to disseminated tuberculosis. Serum immunoglobulin levels should be measured for patients with thymoma and susceptibility to infection.
Keywords
Immunologic deficiency syndromes; Thymoma; Tuberculosis; Opportunistic infections;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Kelesidis T, Yang O. Good's syndrome remains a mystery after 55 years: a systematic review of the scientific evidence. Clin Immunol 2010;135:347-363.   DOI   ScienceOn
2 Kim HI, Chang HH, Park GY, et al. Two cases of cytomegalovirus retinitis as a manifestation of Good's syndrome. Korean J Med 2011;81:266-274.
3 Tarr PE, Sneller MC, Mechanic LJ, et al. Infections in patients with immunodeficiency with thymoma (Good syndrome): report of 5 cases and review of the literature. Medicine (Baltimore) 2001;80:123-133.   DOI   ScienceOn
4 Kim JY, Chin JY, Lee SS, et al. A case of Good syndrome: immunodeficiency syndrome associated with a thymoma. Korean J Med 2008;75:935-941.
5 Agarwal S, Cunningham-Rundles C. Thymoma and immunodeficiency (Good syndrome): a report of 2 unusual cases and review of the literature. Ann Allergy Asthma Immunol 2007;98:185-190.   DOI   ScienceOn
6 Song KH, Kim KH, Kim CJ, et al. A case of Good's syndrome. Infect Chemother 2007;39:259-262.
7 Kim GW, Park JH, Nam EJ, et al. A case of Good's syndrome. J Asthma Allergy Clin Immunol 2002;22:142-147.
8 Ryoo JY. Good's syndrome (thymoma with immunodeficiency): a case report. Korean J Thorac Cardiovasc Surg 2006;39:85-89.
9 Lee SH, Lee SM, Yang SC, et al. A case of granulomatous lung disease in a patient with Good's syndrome. Korean J Intern Med 2008;23:219-222.   DOI   ScienceOn
10 Chung S, Lee K, Kim MJ, et al. A case of Good's syndrome with weak ABO reverse type. Korean J Blood Transfus 2011;22:54-58.