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http://dx.doi.org/10.3904/kjm.2013.85.2.223

A Case of Podostroma Cornu-Damae Intoxication Similar to Drug Hypersensitivity Syndrome  

Yang, Jae Nam (Department of Allergy Medicine, Dongguk University Ilsan Hospital, Dongguk University College of Medicine)
Kang, Ji Hyuk (Department of Allergy Medicine, Dongguk University Ilsan Hospital, Dongguk University College of Medicine)
Kang, Yun Seong (Department of Allergy Medicine, Dongguk University Ilsan Hospital, Dongguk University College of Medicine)
Seok, Soon Ja (Agricultural Microbiology Team, National Academy of Agricultural Science, Rural Development Administration)
Kim, Woo Kyung (Department of Allergy Medicine, Dongguk University Ilsan Hospital, Dongguk University College of Medicine)
Publication Information
The Korean Journal of Medicine / v.85, no.2, 2013 , pp. 223-228 More about this Journal
Abstract
The clinical aspects of intoxication can be similar to those of drug hypersensitivity syndrome, including desquamation, hematologic abnormalities, multiple organ failure, and even death. Many people consume mushrooms that they collect in the mountains, and consequently, the incidence of poisonous mushroom intoxication is increasing. Podostroma cornu-damae is a poisonous mushroom not well-known to the public that contains trichothecene, a deadly poison. It is difficult to differentiate P. cornu-damae from other edible mushrooms, especially young Ganoderma lucidum. Therefore, the general public should be aware of the dangers of indiscreet ingestion of mushrooms. When physicians treat patients presenting clinical symptoms similar to those of drug hypersensitivity reaction following the intake of mushrooms, poisonous mushroom intoxication must be taken into consideration. We report this case together with a literature review, as we experienced one P. cornu-damae intoxication case showing similar clinical aspects to drug hypersensitivity syndrome.
Keywords
Drug hypersensitivity syndrome; Intoxication; Mushroom; Podostroma cornu-damae; Trichothecene;
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1 Bin-Umer MA, McLaughlin JE, Basu D, McCormick S, Tumer NE. Trichothecene mycotoxins inhibit mitochondrial translation: implication for the mechanism of toxicity. Toxin (Basel) 2011;3:1484-1501.   DOI
2 Suzuki M, Katoh Y, Kumagai H, et al. Successful treatment in a case of podostroma cornu-damae poisoning, a deadly poisonous mushroom. Chudoku Kenkyu 2002;15:177-182.
3 Park SK, Kim CK, Hong DS. Three cases of reversible aplastic anemia by Genoderma tsugae. J Soonchunhyang Med Coll 2004;10:719-722.
4 Choi GS, Shin YS, Kim JE, Ye YM, Park HS. Five cases of food allergy to vegetable worm (Cordyceps sinensis) showing cross-reactivity with silkworm pupae. Allergy 2010;65: 1196-1197.
5 McCormick SP, Stanley AM, Stover NA, Alexander NJ. Trichothecenes: from simple to complex mycotoxins. Toxin (Basel) 2011;3:802-814.   DOI
6 Sullivan JR, Shear NH. The drug hypersensitivity syndrome: what is the pathogenesis? Arch Dermatol 2001;137:357-364.
7 Kumari R, Timshina DK, Thappa DM. Drug hypersensitivity syndrome. Indian J Dermatol Venereol Leprol 2011;77: 7-15.   DOI   ScienceOn
8 Park JS, Park KM, Seok SJ, et al. Diversity of poisonous mushroom and investigation on their poisonous substance. Agricultural Science Institute, RDA 2008;533-540.
9 Li Y, Wang Z, Beier RC, et al. T-2 toxin, a trichothecene mycotoxin: review of toxicity, metabolism, and analytical methods. J Agric Food Chem 2011;59:3441-3453.   DOI   ScienceOn