Browse > Article
http://dx.doi.org/10.3904/kjm.2013.85.2.199

A Case of Langerhans Cell Histiocytosis Involving the Lung and Spine of an Adult Patient  

Lee, Chi Hoon (Department of Pulmonary and Critical Care Medicine, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine)
Kang, Sung Wook (Department of Pulmonary and Critical Care Medicine, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine)
Kim, Dong Hee (Department of Pulmonary and Critical Care Medicine, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine)
Min, Joon Ki (Department of Pulmonary and Critical Care Medicine, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine)
Kim, Yee Hyung (Department of Pulmonary and Critical Care Medicine, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine)
Choi, Cheon Woong (Department of Pulmonary and Critical Care Medicine, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine)
Yoo, Jee-Hong (Department of Pulmonary and Critical Care Medicine, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine)
Publication Information
The Korean Journal of Medicine / v.85, no.2, 2013 , pp. 199-204 More about this Journal
Abstract
Langerhans cell histiocytosis (LCH) is a proliferative disease that shares phenotypic characteristics with Langerhans cells (LCs) and involves multiple organs. Here, we report a case of LCH in a 36-year-old male simultaneously involving the lungs and thoracic spine. Chest computed tomography (CT) showed multifocal thin-walled cysts and ill-defined nodular opacities primarily in the bilateral upper and middle lung lobes that fluctuated with smoking. Despite improvement of pulmonary lesions after smoking cessation, osteolytic lesion of thoracic vertebra was aggravated. Symptoms were not improved after nerve block, suggesting vertebral instability that necessitated surgical mass removal and posterior fusion. Microscopically diffuse proliferation of immature, rounded LCs and inflammatory cell infiltration was noted. Although pulmonary LCH in an adult is a benign disease that is usually resolved spontaneously after smoking cessation, surgical treatment should be considered in a case of spinal LCH.
Keywords
Histiocytosis; Langerhans cell; Lung; Spine;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Vassallo R, Ryu JH, Schroeder DR, Decker PA, Limper AH. Clinical outcomes of pulmonary Langerhans'-cell histiocytosis in adults. N Engl J Med 2002;346:484-490.   DOI   ScienceOn
2 Grois N, Potschger U, Prosch H, et al. Risk factors for diabetes insipidus in langerhans cell histiocytosis. Pediatr Blood Cancer 2006;46:228-233.   DOI   ScienceOn
3 Kim C, Jeong SH, Shim JJ, et al. Clinical features of pulmonary langerhans cell histiocytosis in Korea. Tuberc Respir Dis 2009;66:98-103.   DOI   ScienceOn
4 Ahn SW, Ha HG, Kim HW, Ko JH. Adult langerhans cell histiocytosis of the spine presenting with neurological deficits: a case report. Korean J Spine 2010;7:199-201.
5 Yousem SA, Colby TV, Chen YY, Chen WG, Weiss LM. Pulmonary Langerhans' cell histiocytosis: molecular analysis of clonality. Am J Surg Pathol 2001;25:630-636.   DOI   ScienceOn
6 Badalian-Very G, Vergilio JA, Degar BA, Rodriguez- Galindo C, Rollins BJ. Recent advances in the understanding of Langerhans cell histiocytosis. Br J Haematol 2012;156:163-172.   DOI   ScienceOn
7 Tazi A. Adult pulmonary Langerhans' cell histiocytosis. Eur Respir J 2006;27:1272-1285.   DOI   ScienceOn