Browse > Article
http://dx.doi.org/10.3904/kjm.2013.85.1.77

Two Cases of Supraclavicular Lymph Node Metastasis in Pancreatic Adenocarcinoma  

Min, Hyun Jun (Department of Internal Medicine, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine)
Lee, Byoung Moo (Department of Internal Medicine, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine)
Kim, Dae Yong (Department of Internal Medicine, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine)
Ahn, Pyoung (Department of Internal Medicine, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine)
Park, Sang Hyun (Department of Internal Medicine, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine)
Han, Jeung Wan (Department of Internal Medicine, Hangang Sacred Heart Hospital, Hallym University College of Medicine)
Kim, Jin Bong (Department of Internal Medicine, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine)
Publication Information
The Korean Journal of Medicine / v.85, no.1, 2013 , pp. 77-82 More about this Journal
Abstract
The supraclavicular lymph node (SCN) is frequently involved in lymphoma and metastatic malignancies of the breast and lung, but is extremely rarely involved in pancreatic cancer. Only 10 such cases have been reported in the medical literature worldwide. We herein report an additional two cases. An 83-year-old male patient had a 7.6 ${\times}$ 5 cm pancreatic tumor from the pancreatic head to tail, and a 71-year-old male patient had a 2.8 ${\times}$ 1.9 cm pancreatic body tumor. PET-CT revealed SCN metastasis, and subsequent excisional biopsy confirmed metastatic adenocarcinoma. With the more popular use of PET-CT in patients with pancreatic cancer, the number of cases of metastasis to the SCN is expected to increase. This suggests that lymphatic spread is the main metastatic route in pancreatic cancer. Further large-scale studies along with increased numbers of case reports are needed to determine whether lymphatic spread is the main metastatic route in pancreatic cancer.
Keywords
Lymph node; Pancreas cancer; Adenocarcinoma; Metastasis; PET-CT;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Matsuda M, Watanabe G, Hashimoto M. A case of salvage chemotherapy with gemcitabine hydrochloride and nedaplatin for gemcitabine-refractory pancreatic cancer. Gan To Kagaku Ryoho 2008;35:137-139.
2 Nishiyama Y, Yamamoto Y, Yokoe K, et al. Contribution of whole body FDG-PET to the detection of distant metastasis in pancreatic cancer. Ann Nucl Med 2005;19:491-497.   DOI
3 Farma JM, Santillan AA, Melis M, et al. PET/CT fusion scan enhances CT staging in patients with pancreatic neoplasms. Ann Surg Oncol 2008;15:2465-2471.   DOI
4 Soman AD, Collins JM, DePetris G, et al. Isolated supraclavicular lymph node metastasis in pancreatic adenocarcinoma: a report of three cases and review of the literature. JOP 2010;11:604-609.
5 Park SS, Lee KT, Lee KH, et al. Diagnostic usefulness of PET/CT for pancreatic malignancy. Korean J Gastroenterol 2009;54:235-242.   DOI   ScienceOn
6 Lookingbill DP, Spangler N, Sexton FM. Skin involvement as the presenting sign of internal carcinoma: a retrospective study of 7316 cancer patients. J Am Acad Dermatol 1990; 22:19-26.   DOI   ScienceOn
7 Ferrone CR, Brennan MF, Gonen M, et al. Pancreatic adenocarcinoma: the actual 5-year survivors. J Gastrointest Surg 2008;12:701-706.   DOI   ScienceOn
8 Saif MW, Hotchkiss S, Brennan M, Kaley K. Pancreatic adenocarcinoma with supraclavicular lymph node metastasis: is this the Virchow's node? JOP 2011;12:66-67.
9 Kim DI. Cause and treatment of lymphedema. J Korean Med Assoc 2004;47:966-972.   DOI
10 Loh KY, Yushak AW. Images in clinical medicine: Virchow's node (Troisier's sign). N Engl J Med 2007;357:282.   DOI   ScienceOn
11 Windsor JA. Anatomy and physiology of the pancreas. In: Souba WW, Fink MP, Jurkovich GJ, Kaiser LP, Pearce WH, Pemberton JH, Soper NJ, eds. ACS Surgery: Principles & Practice. 6th ed. New York: WebMD Inc., 2006.
12 Horino K, Hiraoka T, Kanemitsu K, et al. Subcutaneous metastases after curative resection for pancreatic carcinoma: a case report and review of the literature. Pancreas 1999;19: 406-408.   DOI   ScienceOn