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http://dx.doi.org/10.3904/kjm.2013.84.3.363

Relationship of Non-Alcoholic Fatty Liver Disease to Colorectal Neoplasia  

Lee, Jue Yong (Department of Internal Medicine, Changwon Fatima Hospital)
Kim, Ja Won (Department of Internal Medicine, Changwon Fatima Hospital)
Publication Information
The Korean Journal of Medicine / v.84, no.3, 2013 , pp. 363-371 More about this Journal
Abstract
Background/Aims: Metabolic syndrome is associated with an increased risk of colorectal cancer. Non-alcoholic fatty liver disease (NAFLD) is regarded as a hepatic manifestation of metabolic syndrome. Increased echogenicity suggesting NAFLD is a frequent incidental finding on ultrasound examination. This study examined whether NAFLD is related to colorectal neoplasia. Methods: We reviewed 1,938 consecutive individuals who underwent screening colonoscopy at Changwon Fatima Hospital between Jan 2009 and Sept 2011. The individuals were divided into adenomatous polyp (Group A; n = 494) and control (Group B; n = 1,444) groups. NAFLD was diagnosed by increased echogenicity on abdominal ultrasound. Results: The prevalence of NAFLD was 171 (34.6%) in group A and 336 (23.3%) in group B. Compared with normal subjects, group A subjects were more likely to be men, older, and have a higher body mass index (BMI), blood pressure, waist circumference, fasting glucose, uric acid, triglyceride, HbA1c, Hb and $\gamma$GT levels, and a higher prevalence of NAFLD, metabolic syndrome, diabetes mellitus, and hypertension. In a multiple logistic regression analysis, older age (${\geq}$ 50 years) (OR 2.051; 95% CI 1.647-2.553), male sex (OR 2.419; 95% CI 1.837-3.184), and prevalence of NAFLD (OR 1.289; 95% CI 1.004-1.655) were associated with an increased risk of adenomatous polyps. Conclusions: NAFLD is associated with a high prevalence of colorectal neoplasia. A fatty liver on abdominal ultrasound might predict the development of colorectal adenomatous polyps and cancer.
Keywords
Non-alcoholic fatty liver disease; Colorectal neoplasms; Early detection of cancer;
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