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http://dx.doi.org/10.3904/kjm.2012.83.4.444

Clinical and Physiopathological Mechanism of Sarcopenia  

Hong, Sang-Mo (Department of Internal Medicine, Hanyang University College of Medicine)
Choi, Woong-Hwan (Department of Internal Medicine, Hanyang University College of Medicine)
Publication Information
The Korean Journal of Medicine / v.83, no.4, 2012 , pp. 444-454 More about this Journal
Abstract
Sarcopenia is defined the loss of muscle mass and strength with aging. Although the etiology and the pathogenesis, the diagnosis of sarcopenia are obscure, the sequel of sarcopenia, i.e. morbidity and mortality, metabolic complications, are a major public health problem. Particularly, aged people in Korea are increasing rapidly more than expected; therefore the interest of sarcopenia is also increasing rapidly. This article provides an overview of the pathogenesis, and diagnosis, epidemiology, clinical results.
Keywords
Aged; Body Composition; Muscle weakness; Sarcopenia;
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1 Winegard KJ, Hicks AL, Sale DG, Vandervoort AA. A 12-year follow-up study of ankle muscle function in older adults. J Gerontol A Biol Sci Med Sci 1996;51:B202-B207.
2 Visser M, Pahor M, Tylavsky F, et al. One- and two-year change in body composition as measured by DXA in a population-based cohort of older men and women. J Appl Physiol 2003;94:2368-2374.   DOI   ScienceOn
3 Bijlsma AY, Meskers CG, Westendorp RG, Maier AB. Chronology of age-related disease definitions: osteoporosis and sarcopenia. Ageing Res Rev 2012;11:320-324.   DOI   ScienceOn
4 Janssen I, Shepard DS, Katzmarzyk PT, Roubenoff R. The healthcare costs of sarcopenia in the United States. J Am Geriatr Soc 2004;52:80-85.   DOI   ScienceOn
5 Rosenberg IH. Sarcopenia: origins and clinical relevance. J Nutr 1997;127(5 Suppl):990S-991S.
6 Baumgartner RN, Koehler KM, Gallagher D, et al. Epidemiology of sarcopenia among the elderly in New Mexico. Am J Epidemiol 1998;147:755-763. Erratum in: Am J Epidemiol 1999;149:1161.   DOI   ScienceOn
7 Short KR, Nair KS. The effect of age on protein metabolism. Curr Opin Clin Nutr Metab Care 2000;3:39-44.   DOI   ScienceOn
8 Houston DK, Nicklas BJ, Ding J, et al. Dietary protein intake is associated with lean mass change in older, communitydwelling adults: the Health, Aging, and Body Composition (Health ABC) Study. Am J Clin Nutr 2008;87:150-155.   DOI
9 Castaneda C, Charnley JM, Evans WJ, Crim MC. Elderly women accommodate to a low-protein diet with losses of body cell mass, muscle function, and immune response. Am J Clin Nutr 1995;62:30-39.   DOI
10 Campbell WW, Trappe TA, Wolfe RR, Evans WJ. The recommended dietary allowance for protein may not be adequate for older people to maintain skeletal muscle. J Gerontol A Biol Sci Med Sci 2001;56:M373-M380.   DOI
11 Volpi E, Ferrando AA, Yeckel CW, Tipton KD, Wolfe RR. Exogenous amino acids stimulate net muscle protein synthesis in the elderly. J Clin Invest 1998;101:2000-2007.   DOI   ScienceOn
12 Volpi E, Kobayashi H, Sheffield-Moore M, Mittendorfer B, Wolfe RR. Essential amino acids are primarily responsible for the amino acid stimulation of muscle protein anabolism in healthy elderly adults. Am J Clin Nutr 2003;78:250-258.   DOI
13 Fiatarone MA, O'Neill EF, Ryan ND, et al. Exercise training and nutritional supplementation for physical frailty in very elderly people. N Engl J Med 1994;330:1769-1775.   DOI   ScienceOn
14 Volpi E, Mittendorfer B, Rasmussen BB, Wolfe RR. The response of muscle protein anabolism to combined hyperaminoacidemia andglucose-induced hyperinsulinemia is impaired in the elderly. J Clin Endocrinol Metab 2000; 85:4481-4490.   DOI   ScienceOn
15 Zadik Z, Chalew SA, McCarter RJ Jr, Meistas M, Kowarski AA. The influence of age on the 24-hour integrated concentration of growth hormone in normal individuals. J Clin Endocrinol Metab 1985;60:513-516.   DOI
16 Moller N, Vendelbo MH, Kampmann U, et al. Growth hormone and protein metabolism. Clin Nutr 2009;28: 597-603.   DOI   ScienceOn
17 Rudman D, Feller AG, Nagraj HS, et al. Effects of human growth hormone in men over 60 years old. N Engl J Med 1990;323:1-6.   DOI   ScienceOn
18 Papadakis MA, Grady D, Black D, et al. Growth hormone replacement in healthy older men improves body composition but not functional ability. Ann Intern Med 1996;124:708-716.   DOI   ScienceOn
19 Haren MT, Siddiqui AM, Armbrecht HJ, et al. Testosterone modulates gene expression pathways regulating nutrient accumulation, glucose metabolism and protein turnover in mouse skeletal muscle. Int J Androl 2011;34:55-68.   DOI   ScienceOn
20 Nass R, Thorner MO. Impact of the GH-cortisol ratio on the age-dependent changes in body composition. Growth Horm IGF Res 2002;12:147-161.   DOI   ScienceOn
21 Morley JE. Weight loss in older persons: new therapeutic approaches. Curr Pharm Des 2007;13:3637-3647.   DOI   ScienceOn
22 Ziambaras K, Dagogo-Jack S. Reversible muscle weakness in patients with vitamin D deficiency. West J Med 1997;167: 435-439.
23 Visser M, Deeg DJ, Lips P; Longitudinal Aging Study Amsterdam. Low vitamin D and high parathyroid hormone levels as determinants of loss of muscle strength and muscle mass (sarcopenia): the Longitudinal Aging Study Amsterdam. J Clin Endocrinol Metab 2003;88:5766-5772.   DOI   ScienceOn
24 Moreira-Pfrimer LD, Pedrosa MA, Teixeira L, Lazaretti- Castro M. Treatment of vitamin D deficiency increases lower limb muscle strength in institutionalized older people independently of regular physical activity: a randomized double-blind controlled trial. Ann Nutr Metab 2009;54: 291-300.   DOI   ScienceOn
25 Bischoff HA, Stähelin HB, Dick W, et al. Effects of vitamin D and calcium supplementation on falls: a randomized controlled trial. J Bone Miner Res 2003;18:343-351.   DOI   ScienceOn
26 Flicker L, MacInnis RJ, Stein MS, et al. Should older people in residential care receive vitamin D to prevent falls? results of a randomized trial. J Am Geriatr Soc 2005;53:1881-1888.   DOI   ScienceOn
27 Fong Y, Moldawer LL, Marano M, et al. Cachectin/TNF or IL-1 alpha induces cachexia with redistribution of body proteins. Am J Physiol 1989;256(3 Pt 2):R659-R665.
28 Lang CH, Frost RA, Nairn AC, MacLean DA, Vary TC. TNF-alpha impairs heart and skeletal muscle protein synthesis by altering translation initiation. Am J Physiol Endocrinol Metab 2002;282:E336-E347.   DOI
29 Dirks AJ, Leeuwenburgh C. Tumor necrosis factor alpha signaling in skeletal muscle: effects of age and caloric restriction. J Nutr Biochem 2006;17:501-508.   DOI   ScienceOn
30 Dupont-Versteegden EE. Apoptosis in muscle atrophy: relevance to sarcopenia. Exp Gerontol 2005;40:473-481.   DOI   ScienceOn
31 Braga M, Sinha Hikim AP, Datta S, et al. Involvement of oxidative stress and caspase 2-mediated intrinsic pathway signaling in age-related increase in muscle cell apoptosis in mice. Apoptosis 2008;13:822-832.   DOI   ScienceOn
32 Leeuwenburgh C, Gurley CM, Strotman BA, Dupont- Versteegden EE. Age-related differences in apoptosis with disuse atrophy in soleus muscle. Am J Physiol Regul Integr Comp Physiol 2005;288:R1288-R1296.   DOI   ScienceOn
33 Baker DJ, Hepple RT. Elevated caspase and AIF gene expression correlate with progression of sarcopenia during aging in male F344BN rats. Exp Gerontol 2006;41: 1149-1156.   DOI   ScienceOn
34 Mordier S, Deval C, Béchet D, Tassa A, Ferrara M. Leucine limitation induces autophagy and activation of lysosome-d ependent proteolysis in C2C12 myotubes through a mammalian target of rapamycin-independent signaling pathway. J Biol Chem 2000;275:29900-29906.   DOI   ScienceOn
35 Goll DE, Thompson VF, Li H, Wei W, Cong J. The calpain system. Physiol Rev 2003;83:731-801.   DOI
36 Brule C, Dargelos E, Diallo R, et al. Proteomic study of calpain interacting proteins during skeletal muscle aging. Biochimie 2010;92:1923-1933.   DOI   ScienceOn
37 Gomes MD, Lecker SH, Jagoe RT, Navon A, Goldberg AL. Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy. Proc Natl Acad Sci USA 2001;98: 14440-14445.   DOI   ScienceOn
38 Bodine SC, Latres E, Baumhueter S, et al. Identification of ubiquitin ligases required for skeletal muscle atrophy. Science 2001;294:1704-1708.   DOI   ScienceOn
39 Kadi F, Ponsot E. The biology of satellite cells and telomeres in human skeletal muscle: effects of aging and physical activity. Scand J Med Sci Sports 2010;20:39-48.
40 Corbu A, Scaramozza A, Badiali-DeGiorgi L, et al. Satellite cell characterization from aging human muscle. Neurol Res 2010;32:63-72.   DOI   ScienceOn
41 Janssen I, Baumgartner RN, Ross R, Rosenberg IH, Roubenoff R. Skeletal muscle cutpoints associated with elevated physical disability risk in older men and women. Am J Epidemiol 2004;159:413-421.   DOI   ScienceOn
42 Kovacheva EL, Hikim AP, Shen R, Sinha I, Sinha-Hikim I. Testosterone supplementation reverses sarcopenia in aging through regulation of myostatin, c-Jun NH2-terminal kinase, Notch, and Akt signaling pathways. Endocrinology 2010; 151:628-638..   DOI   ScienceOn
43 Newman AB, Kupelian V, Visser M, et al. Sarcopenia: alternative definitions and associations with lower extremity function. J Am Geriatr Soc 2003;51:1602-1609.   DOI   ScienceOn
44 Janssen I, Heymsfield SB, Ross R. Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability. J Am Geriatr Soc 2002;50:889-896.   DOI   ScienceOn
45 Janssen I. Influence of sarcopenia on the development of physical disability: the Cardiovascular Health Study. J Am Geriatr Soc 2006;54:56-62.   DOI   ScienceOn
46 Pahor M, Manini T, Cesari M. Sarcopenia: clinical evaluation, biological markers and other evaluation tools. J Nutr Health Aging 2009;13:724-728.
47 Cesari M, Leeuwenburgh C, Lauretani F, et al. Frailty syndrome and skeletal muscle: results from the Invecchiare in Chianti study. Am J Clin Nutr 2006;83:1142-1148.   DOI
48 Guralnik JM, Ferrucci L, Simonsick EM, Salive ME, Wallace RB. Lower-extremity function in persons over the age of70 years as a predictor of subsequent disability. N Engl J Med 1995;332:556-561.   DOI   ScienceOn
49 Hong S, Oh HJ, Choi H, et al. Characteristics of body fat, body fat percentage and other body composition for Koreans from KNHANES IV. J Korean Med Sci 2011;26:1599-1605.   DOI   ScienceOn
50 Visser M, Harris TB, Langlois J, et al. Body fat and skeletal muscle mass in relation to physical disability in very old men and women of the Framingham Heart Study. J Gerontol A Biol Sci Med Sci 1998;53:M214-M221.
51 Sternfeld B, Ngo L, Satariano WA, Tager IB. Associations of body composition with physical performance and selfreported functional limitation in elderly men and women. Am J Epidemiol 2002;156:110-121.   DOI   ScienceOn
52 Visser M, Deeg DJ, Lips P, Harris TB, Bouter LM. Skeletal muscle mass and muscle strength in relation to lowerextremity performance in older men and women. J Am Geriatr Soc 2000;48:381-386.
53 Visser M, Langlois J, Guralnik JM, et al. High body fatness, but not low fat-free mass, predicts disability in older men and women: the Cardiovascular Health Study. Am J Clin Nutr 1998;68:584-590.   DOI
54 Visser M, Goodpaster BH, Kritchevsky SB, et al. Muscle mass, muscle strength, and muscle fat infiltration as predictors of incident mobility limitations in well-functioning older persons. J Gerontol A Biol Sci Med Sci 2005;60:324-333.   DOI   ScienceOn
55 Bouchard DR, Janssen I. Dynapenic-obesity and physical function in older adults. J Gerontol A Biol Sci Med Sci 2010;65:71-77.
56 Lauretani F, Russo CR, Bandinelli S, et al. Age-associated changes in skeletal muscles and their effect on mobility: an operational diagnosis of sarcopenia. J Appl Physiol 2003;95: 1851-1860.
57 Visser M, Schaap LA. Consequences of sarcopenia. Clin Geriatr Med 2011;27:387-399.   DOI   ScienceOn
58 Ravussin E, Lillioja S, Anderson TE, Christin L, Bogardus C. Determinants of 24-hour energy expenditure in man: methods and results using a respiratory chamber. J Clin Invest 1986;78:1568-1578.   DOI   ScienceOn
59 Miller MD, Crotty M, Giles LC, et al. Corrected arm muscle area: an independent predictor of long-term mortality in community-dwelling older adults? J Am Geriatr Soc 2002; 50:1272-1277.   DOI   ScienceOn
60 Enoki H, Kuzuya M, Masuda Y, et al. Anthropometric measurements of mid-upper arm as a mortality predictor for community-dwelling Japanese elderly: the Nagoya Longitudinal Study of Frail Elderly (NLS-FE). Clin Nutr 2007; 26:597-604.   DOI   ScienceOn
61 Cesari M, Pahor M, Lauretani F, et al. Skeletal muscle and mortality results from the InCHIANTI Study. J Gerontol A Biol Sci Med Sci 2009;64:377-384.
62 Szulc P, Munoz F, Marchand F, Chapurlat R, Delmas PD. Rapid loss of appendicular skeletal muscle mass is associated with higher all-cause mortality in older men: the prospective MINOS study. Am J Clin Nutr 2010;91:1227-1236.   DOI   ScienceOn
63 Newman AB, Kupelian V, Visser M, et al. Strength, but not muscle mass, is associated with mortality in the health, aging and body composition study cohort. J Gerontol A Biol Sci Med Sci 2006;61:72-77.   DOI   ScienceOn
64 Roubenoff R, Parise H, Payette HA, et al. Cytokines, insulin-like growth factor 1, sarcopenia, and mortality in very old community-dwelling men and women: the Framingham Heart Study. Am J Med 2003;115:429-435.   DOI   ScienceOn
65 Rantanen T, Volpato S, Ferrucci L, Heikkinen E, Fried LP, Guralnik JM. Handgrip strength and cause-specific and total mortality in older disabled women: exploring the mechanism. J Am Geriatr Soc 2003;51:636-641.   DOI   ScienceOn