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http://dx.doi.org/10.3904/kjm.2012.83.2.263

Transformation of CD5-Negative Follicular Lymphoma into CD5-Positive Diffuse Large B-Cell Lymphoma: A Case Report  

Kim, Hyeong-Kug (Department of Internal Medicine, Eulji University Hospital, Eulji University School of Medicine)
Cho, In-Sung (Department of Internal Medicine, Eulji University Hospital, Eulji University School of Medicine)
Lee, Hye-Kyung (Department of Pathology, Eulji University Hospital, Eulji University School of Medicine)
Choi, Yong-Hun (Department of Internal Medicine, Eulji University Hospital, Eulji University School of Medicine)
Cho, Seong-Min (Department of Internal Medicine, Eulji University Hospital, Eulji University School of Medicine)
Moon, Hyun-Jin (Department of Internal Medicine, Eulji University Hospital, Eulji University School of Medicine)
Lee, Jin-A (Department of Internal Medicine, Eulji University Hospital, Eulji University School of Medicine)
Publication Information
The Korean Journal of Medicine / v.83, no.2, 2012 , pp. 263-267 More about this Journal
Abstract
Diffuse large B-cell lymphoma (DLBCL) is the most frequent subtype of aggressive lymphomas. Approximately 10% of DLBCL cases express CD5 as a surface antigen. CD5-positive DLBCL can occur as the de novo or secondary type. De novo CD5-positive DLBCL arises without previous lymphoproliferative disease, and secondary CD5-positive DLBCL may or may not manifest as Richter syndrome. The transformation of follicular lymphoma (FL) into DLBCL occurs in approximately one-third of all cases. The transformation of CD5-negative low-grade B-cell lymphoma to CD5-positive DLBCL is extremely rare. We report the clinical features of a rare case that presented with a transformation from CD5-negative FL to CD5-positive DLBL over 11 years. This is the second such case published in the English literature.
Keywords
Lymphoma; large B-cell; diffuse; Lymphoma; follicular; Cell transformation; neoplastic;
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