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http://dx.doi.org/10.3904/kjm.2012.82.6.764

Renal Parenchymal Malakoplakia Presenting with Abscesses and Hepatic Extension Misdiagnosed as a Malignant Tumor: A Case Report  

Yoon, Sun-Young (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine)
Lee, Hyo-Jeong (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine)
An, Ji-Hyun (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine)
Kim, Su-Jeong (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine)
Kim, Sang-We (Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine)
Woo, Jun-Hee (Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine)
Kim, Yang-Soo (Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine)
Publication Information
The Korean Journal of Medicine / v.82, no.6, 2012 , pp. 764-768 More about this Journal
Abstract
Malakoplakia is a chronic inflammatory disorder that usually affects the urinary tract in immunocompromised patients and rarely extends to adjacent organs. Due to its mass-like presentation, malakoplakia is often clinically misdiagnosed as a neoplastic lesion. We describe the case of a 51-year-old female with renal malakoplakia and hepatic extension and large intraperitoneal abscesses that had been misdiagnosed as malignancy. She was diagnosed with myasthenia gravis 12 years prior and had been treated with oral corticosteroids and immunosuppressants. Radical nephrectomy concomitant with abscess drainage was performed. The final pathology was compatible with malakoplakia, and the patient was successfully treated with antibiotics. Although renal malakoplakia is a rare disease, it should be included in the differential diagnosis of patients with a renal mass who have a history of recurrent urinary tract infections or evidence of immunosuppression.
Keywords
Kidney; Liver; Malakoplakia;
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1 Michaelis L, Gutmann C. Uber einschlüsse in blasentumoren. Z Klin Med 1902;47:208-215.
2 Dobyan DC, Truong LD, Eknoyan G. Renal malacoplakia reappraised. Am J Kidney Dis 1993;22:243-252.   DOI
3 Sung DE, Yu E, Kim CS, Ro JY. Renal malakoplakia with secondary hepatic extension: a case report. Korean J Pathol 2003;37:199-203.
4 Stanton MJ, Maxted W. Malacoplakia: a study of the literature and current concepts of pathogenesis, diagnosis and treatment. J Urol 1981;125:139-146.   DOI
5 Daroux M, Frimat M, Mirault T, et al. Renal malakoplakia: an underestimate cause of renal failure. Nephrol Ther 2011; 7:111-116.   DOI   ScienceOn
6 Jo YI, Yoo TS, Heo WM, et al. A case of renal malakoplakia with renal insufficiency. Korean J Med 1996;51:843-849.
7 Terner JY, Lattes R. Malakoplakia of colon and retroperitoneum: report of a case with a histochemical study of the Michaelis-Gutman inclusion bodies. Am J Clin Pathol 1965; 44:20-31.   DOI
8 Abdou NI, NaPombejara C, Sagawa A, et al. Malakoplakia: evidence for monocyte lysosomal abnormality correctable by cholinergic agonist in vitro and in vivo. N Engl J Med 1977;297:1413-1419.   DOI   ScienceOn
9 Oliver JM. Impaired microtubule function correctable by cyclic GMP and cholinergic agonists in the Chediak-Higashi syndrome. Am J Pathol 1976;85:395-418.
10 Curran KA, Peterson JC, Croker BP, Drane WE, Tisher CC. Gallium scan in the diagnosis and treatment of renal malacoplakia. Am J Nephrol 1990;10:416-421.   DOI   ScienceOn
11 Tam VK, Kung WH, Li R, Chan KW. Renal parenchymal malacoplakia: a rare cause of ARF with a review of recent literature. Am J Kidney Dis 2003;41:E13-E17.   DOI   ScienceOn