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http://dx.doi.org/10.3904/kjm.2012.82.5.618

Renal Infarction after NSAID Treatment  

Yoon, Se-Hee (Department of Internal Medicine, Kyungpook National University School of Medicine)
Kim, Yong-Lim (Department of Internal Medicine, Kyungpook National University School of Medicine)
Park, Sun-Hee (Department of Internal Medicine, Kyungpook National University School of Medicine)
Kim, Chan-Duck (Department of Internal Medicine, Kyungpook National University School of Medicine)
Choi, Ji-Young (Department of Internal Medicine, Kyungpook National University School of Medicine)
Yun, Sung-Ro (Department of Internal Medicine, Konyang University College of Medicine)
Publication Information
The Korean Journal of Medicine / v.82, no.5, 2012 , pp. 618-622 More about this Journal
Abstract
Nonsteroidal anti-inflammatory drugs (NSAIDs) are popular in general practice. Their adverse renal effects have been well documented. Common NSAID-related renal side effects range from dysfunctional renal hemodynamic responses, nephrotic syndrome, electrolyte disturbances, acute interstitial nephritis, chronic interstitial nephritis with papillary necrosis, and acute flank pain syndrome to acute renal failure. Decreased prostaglandin synthesis can lead to renal ischemia and hemodynamically related acute renal failure. Cases of acute renal failure syndrome accompanied by severe loin pain after anaerobic exercise (ALPE) or binge drinking have previously been reported in individuals taking NSAIDs. However, severe flank pain after high-dose NSAID treatment in the absence of other conditions (exercise or volume contraction) is rare. We report a case of a 51-year-old man who suffered from severe pain in both flanks after NSAID treatment. Computed tomography revealed hypodense lesions in both kidneys.
Keywords
NSAID; Infarction; Kidney;
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1 Harirforoosh S, Jamali F. Renal adverse effects of nonsteroidal anti-inflammatory drugs. Expert Opin Drug Saf 2009;8:669-681.   DOI   ScienceOn
2 Ishikawa I. Acute renal failure with severe loin pain and patchy renal ischemia after anaerobic exercise in patients with or without renal hypouricemia. Nephron 2002;91:559-570.   DOI   ScienceOn
3 Kim HS, Yoon SI, Cheoi KS, Joung KO, Kwon SK, Kim HY. Two cases of patchy renal vasoconstriction without antecedent anaerobic exercise. Korean J Nephrol 2006;25:841-846.
4 Johnson GR, Wen SF Syndrome of flank pain and acute renal failure after binge drinking and nonsteroidal anti-inflammatory drug ingestion. J Am Soc Nephrol 1995;5:1647-1652.
5 Ruilope LM, Garcia Robles R, Paya C, et al. Effects of long-term treatment with indomethacin on renal function. Hypertension 1986;8:677-684.   DOI
6 Scharschmidt LA, Dunn MJ. Prostaglandin synthesis by rat glomerular mesangial cells in culture: effects of angiotensin II and arginine vasopressin. J Clin Invest 1983;71:1756-1764.   DOI
7 Hura CE, Kunau RT Jr. Angiotensin II-stimulated prostaglandin production by canine renal afferent arterioles. Am J Physiol 1988;254(5 Pt 2):F734-F738.
8 Jeong JY, Kim SH, Lee HJ, Sim JS. Atypical low-signal-intensity renal parenchyma: causes and patterns. Radiographics 2002;22:833-846.   DOI
9 Meyrier A, Becquemont L, Simon P, Laaban JP. Protracted anuria due to active vasoconstriction in primary or secondary malignant hypertension. Nephrol Dial Transplant 1990;5:174-178.   DOI   ScienceOn
10 Mamdani BH, Lim VS, Mahurkar SD, Katz AI, Dunea G. Recovery from prolonged renal failure in patients with accelerated hypertension. N Engl J Med 1974;291:1343-1344.   DOI   ScienceOn
11 Griffin KA, Picken M, Bidani AK. Method of renal mass reduction is a critical modulator of subsequent hypertension and glomerular injury. J Am Soc Nephrol 1994;4:2023-2031.
12 Findling JW, Waters VO, Raff H. The dissociation of renin and aldosterone during critical illness. J Clin Endocrinol Metab 1987;64:592-595.   DOI
13 Zipser RD, Davenport MW, Martin KL, et al. Hyperreninemic hypoaldosteronism in the critically ill: a new entity. J Clin Endocrinol Metab 1981;53:867-873.   DOI
14 Martin I, Basso N, Aguirre F, SArchi MI. Changes in the renin-angiotensin-aldosterone system in 2 kidney -2 clip Goldblatt hypertensive rats of both sexes submitted to chronic hypobaric hypoxia. Arch Int Physiol Biochim Biophys 1994;102:209-214.   DOI
15 Fiad TM, Cunningham SK, Hayes FJ, McKenna TJ. Effects of nifedipine treatment on the renin-angiotensin-aldosterone axis. J Clin Endocrinol Metab 1997;82:457-460.   DOI   ScienceOn
16 Korzets Z, Plotkin E, Bernheim J, Zissin R. The clinical spectrum of acute renal infarction. Isr Med Assoc J 2002;4:781-784.
17 Paris B, Bobrie G, Rossignol P, Le Coz S, Chedid A, Plouin PF. Blood pressure and renal outcomes in patients with kidney infarction and hypertension. J Hypertens 2006;24:1649-1654.   DOI   ScienceOn