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http://dx.doi.org/10.3904/kjm.2012.82.5.603

Localized Uterine Recurrence of Hepatocellular Carcinoma 4 Years after Curative Resection  

Lee, Sang-Jin (Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine)
Shin, Jung-Woo (Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine)
Park, Neung-Hwa (Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine)
Nah, Yang-Won (Department of Surgery, Ulsan University Hospital, University of Ulsan College of Medicine)
Yoo, Hang-Jo (Department of Obstetrics and Gynecology, Ulsan University Hospital, University of Ulsan College of Medicine)
Jung, Yoong-Ki (Department of Radiology, Ulsan University Hospital, University of Ulsan College of Medicine)
Choi, Hye-Jeong (Department of Pathology, Ulsan University Hospital, University of Ulsan College of Medicine)
Publication Information
The Korean Journal of Medicine / v.82, no.5, 2012 , pp. 603-608 More about this Journal
Abstract
Extrahepatic metastasis of hepatocellular carcinoma (HCC) can be found in various organs, but metastasis to the female genital tract is extremely rare. A 48-year-old woman who had undergone curative left lobectomy for small HCC 4 years earlier was admitted because of sequential alpha-fetoprotein elevation. Upon abdominal MRI and hepatic angiography, no evidence of HCC recurrence was found in the remnant liver. However, a positron emission tomography CT scan showed a hypermetabolic lesion in the uterine fundus, which was revealed as metastatic HCC after total hysterectomy. This is, to our knowledge, the first documented case of metastatic uterine tumor that originated from HCC without intrahepatic recurrence.
Keywords
Hepatocellular carcinoma; Uterine neoplasm; Metastatic neoplasm;
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Times Cited By KSCI : 1  (Citation Analysis)
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1 Uka K, Aikata H, Takaki S, et al. Clinical features and prognosis of patients with extrahepatic metastases from hepatocellular carcinoma. World J Gastroenterol 2007;13:414-420.   DOI
2 Lo CM, Lai EC, Fan ST, Choi TK, Wong J. Resection for extrahepatic recurrence of hepatocellular carcinoma. Br J Surg 1994;81:1019-1021.   DOI   ScienceOn
3 Poon RT, Fan ST, O'Suilleabhain CB, Wong J. Aggressive management of patients with extrahepatic and intrahepatic recurrences of hepatocellular carcinoma by combined resection and locoregional therapy. J Am Coll Surg 2002;195:311-318.   DOI   ScienceOn
4 Yang Y, Nagano H, Ota H, et al. Patterns and clinicopathologic features of extrahepatic recurrence of hepatocellular carcinoma after curative resection. Surgery 2007;141:196-202.   DOI   ScienceOn
5 Kumar A, Schneider V. Metastases to the uterus from extrapelvic primary tumors. Int J Gynecol Pathol 1983;2:134-140.   DOI
6 Katyal S, Oliver JH 3rd, Peterson MS, Ferris JV, Carr BS, Baron RL. Extrahepatic metastases of hepatocellular carcinoma. Radiology 2000;216:698-703.   DOI
7 Natsuizaka M, Omura T, Akaike T, et al. Clinical features of hepatocellular carcinoma with extrahepatic metastases. J Gastroenterol Hepatol 2005;20:1781-1787.   DOI   ScienceOn
8 Charache H. Metastatic carcinoma in the uterus. Am J Surg 1941;53:152-157.   DOI   ScienceOn
9 Ryo E, Sato T, Takeshita S, Ayabe T, Tanaka F. Uterine metastasis from hepatocellular carcinoma: a case report. Int J Gynecol Cancer 2006;16:1894-1896.   DOI   ScienceOn
10 Kang WD, Kim CH, Cho MK, et al. Hepatocellular carcinoma presenting as uterine metastasis. Cancer Res Treat 2008;40:141-144.   DOI   ScienceOn
11 Park UJ, Kim YH, Kang KJ, Lim TJ. Risk factors for early recurrence after surgical resection for hepatocellular carcinoma. Korean J Hepatol 2008;14:371-380.   DOI   ScienceOn
12 Kanda M, Tateishi R, Yoshida H, et al. Extrahepatic metastasis of hepatocellular carcinoma: incidence and risk factors. Liver Int 2008;28:1256-1263.   DOI   ScienceOn
13 Zhang BH, Yang BH, Tang ZY. Randomized controlled trial of screening for hepatocellular carcinoma. J Cancer Res Clin Oncol 2004;130:417-422.
14 Nobuoka D, Kato Y, Gotohda N, et al. Postoperative serum alpha-fetoprotein level is a useful predictor of recurrence after hepatectomy for hepatocellular carcinoma. Oncol Rep 2010;24:521-528.
15 Shin WY, Suh KS, Kim T, Jeon YM, Yi NJ, Lee KU. Could patients who underwent hepatic resection due to hepatocellular carcinoma with high alpha-fetoprotein be monitored for recurrence by alpha-fetoprotein level? Korean J Hepatol 2010;16: 168-175.   DOI   ScienceOn
16 Stemmermann GN. Extrapelvic carcinoma metastatic to the uterus. Am J Obstet Gynecol 1961;82:1261-1266.   DOI
17 So BJ, Bekaii-Saab T, Bloomston MA, Patel T. Complete clinical response of metastatic hepatocellular carcinoma to sorafenib in a patient with hemochromatosis: a case report. J Hematol Oncol 2008;1:18.   DOI   ScienceOn
18 Yeganeh M, Finn RS, Saab S. Apparent remission of a solitary metastatic pulmonary lesion in a liver transplant recipient treated with sorafenib. Am J Transplant 2009;9:2851-2854.   DOI   ScienceOn