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http://dx.doi.org/10.3904/kjm.2012.82.4.512

A Case of Lactic Acidosis Caused by Linezolid Treatment of Persistent Methicillin-Resistant Staphylococcus Aureus Bacteremia  

Kim, Yu-Seok (Department of Internal Medicine, Asan Medical Center, Ulsan University College of Medicine)
Kim, Ji-Beom (Department of Internal Medicine, Asan Medical Center, Ulsan University College of Medicine)
Lee, Yu-Mi (Department of Internal Medicine, Asan Medical Center, Ulsan University College of Medicine)
Kim, Sung-Han (Department of Internal Medicine, Asan Medical Center, Ulsan University College of Medicine)
Choi, Sang-Ho (Department of Internal Medicine, Asan Medical Center, Ulsan University College of Medicine)
Woo, Jun-Hee (Department of Internal Medicine, Asan Medical Center, Ulsan University College of Medicine)
Kim, Yang-Soo (Department of Internal Medicine, Asan Medical Center, Ulsan University College of Medicine)
Publication Information
The Korean Journal of Medicine / v.82, no.4, 2012 , pp. 512-515 More about this Journal
Abstract
Linezolid is an antibiotic in the oxazolidinone family that works as a bacterial protein synthesis inhibitor. It is used for the treatment of Gram-positive, multidrug-resistant bacteria. Adverse effects of linezolid include bone marrow suppression, peripheral or optic neuropathy, and, less commonly, lactic acidosis. Lactic acidosis usually occurs as a result of cardiopulmonary failure or sepsis, but it is sometimes caused by drugs, such as linezolid, and treatment of such lactic acidosis involves cessation of the drug. We report a case of lactic acidosis caused by the use of linezolid for the treatment of persistent methicillin-resistant Staphylococcus aureus bacteremia, which occurred after endoscopic sclerotherapy of gastic varices.
Keywords
Lactic acidosis; Linezolid; Methicillin-resistant Staphylococcus aureus;
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