Browse > Article
http://dx.doi.org/10.3904/kjm.2012.82.4.449

A Case of Duodenal Ulcer Perforation Combined with Scrub Typhus  

Kang, Jong-Won (Department of Internal Medicine, Gangneung Asan Hospital, University of Ulsan College of Medicine)
Jeong, Woo-Jin (Department of Internal Medicine, Gangneung Asan Hospital, University of Ulsan College of Medicine)
Lee, Kyoung-Won (Department of Internal Medicine, Gangneung Asan Hospital, University of Ulsan College of Medicine)
Lee, Sang-Jin (Department of Internal Medicine, Gangneung Asan Hospital, University of Ulsan College of Medicine)
Lee, Joung-Hwa (Department of Internal Medicine, Gangneung Asan Hospital, University of Ulsan College of Medicine)
Kim, Young-Don (Department of Internal Medicine, Gangneung Asan Hospital, University of Ulsan College of Medicine)
Cheon, Gab-Jin (Department of Internal Medicine, Gangneung Asan Hospital, University of Ulsan College of Medicine)
Publication Information
The Korean Journal of Medicine / v.82, no.4, 2012 , pp. 449-452 More about this Journal
Abstract
Scrub typhus is an acute febrile illness that results from the destruction of endothelial cells by Orientia tsutsugamushi and subsequent systemic vasculitis. It manifests as fever, headache, myalgia, eschar formation, and lymphadenopathy. Some authors have reported that such vasculitis involves the gastrointestinal tract and that hyperemia, erosion, ulceration, and active bleeding of the gastric mucosa subsequently develop. However, no case of ulcer perforation in a patient with scrub typhus has been reported to date. Here, we report the case of a perforated duodenal ulcer in a 70-year-old female patient with scrub typhus.
Keywords
Scrub typhus; Duodenal ulcer; Perforation;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Kim SJ, Chung IK, Chung IS, et al. The clinical significance of upper gastrointestinal endoscopy in gastrointestinal vasculitis related to scrub typhus. Endoscopy 2000;32:950-955.   DOI   ScienceOn
2 Park JH, Shim SG. Upper gastrointestinal endoscopic features and predictable factors for clinical severity in the patients with tsutsugamushi disease. 2005;69:518-527.
3 Park JY, Cho MS, Shim KN, Lee YJ, Choe HJ. The clinical feature and pathogenesis of gastroduodenal lesion in patients with scrub typhus. Korean J Med 2008;74:648-657.
4 Yang YS, Lee HS, Yoon BG, Lee CG, Lee JG. Two cases of Gastric ulcer bleeding combined with Scrub typhus. Korean J Gastrointest Endosc 2004;29:426A.
5 Aung-Thu, Supanaranond W, Phumiratanaprapin W, Phonrat B, Chinprasatsak S, Ratanajaratroj N. Gastrointestinal manifestations of septic patients with scrub typhus in Maharat Nakhon Ratchasima hospital. Southeast Asian J Trop Med Public Health 2004;35:845-851.
6 Moron CG, Popov VL, Feng HM, Wear D, Walker DH. Identification of the target cells of Orientia tsutsugamushi in human cases of scrub typhus. Mod Pathol 2001;14:752-759.   DOI   ScienceOn
7 Allen AC, Spitz S. A comparative study of the pathology of scrub typhus (tustsugamushi disease) and other rickettsial disease. Am J Pathol 1945;21:603-681.
8 Chi WC, Huang JJ, Sung JM, Lan RR, Ko WC, Chen FF. Scrub typhus associated with multiorgan failure: a case report. Scand J Infect Dis 1997;29:634-635.   DOI   ScienceOn
9 Walker TS, Mellott GE. Rickettsial stimulation of endothelial platelet-activating factor synthesis. Infect Immun 1993;61: 2024-2029.
10 Lee JK, Lee BS, Shin OS, Shin KC, Oh YG, Ki SK. A clinical study of tsutsugamushi disease that occurred in the autumns of 1989, and 1990. Korean J Med 1991;41:558-563.
11 Berman SJ, Kundin WD. Scrub typhus in South Vietnam: a study of 87 cases. Ann Intern Med 1973;79:26-30.   DOI   ScienceOn
12 Jeong YJ, Kim S, Wook YD, Lee JW, Kim KI, Lee SH. Scrub typhus: clinical, pathologic, and imaging findings. Radiographics 2007;27:161-172.   DOI   ScienceOn