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http://dx.doi.org/10.3904/kjm.2012.82.3.371

A Case of Linezolid-Associated Lactic Acidosis  

Lee, Hong-Joo (Department of Internal Medicine, Kyung Hee University College of Medicine)
Choi, Jae-Ho (Department of Internal Medicine, Kyung Hee University College of Medicine)
Kim, Sun-Yong (Department of Internal Medicine, Kyung Hee University College of Medicine)
Chung, Kyung-Hwan (Department of Internal Medicine, Kyung Hee University College of Medicine)
Lee, Tae-Won (Department of Internal Medicine, Kyung Hee University College of Medicine)
Ihm, Chun-Gyoo (Department of Internal Medicine, Kyung Hee University College of Medicine)
Moon, Ju-Young (Department of Internal Medicine, Kyung Hee University College of Medicine)
Publication Information
The Korean Journal of Medicine / v.82, no.3, 2012 , pp. 371-373 More about this Journal
Abstract
Linezolid has been used for treatment of vancomycin-resistant Enterococcus faecium infection, nosocomial pneumonia caused by Staphylococcus aureus, including methicillin-resistant Staphylococcus aureus or Streptococcus pneumoniae, and complicated and uncomplicated skin and skin structure infections. Lactic acidosis is an adverse effect associated with drugs, including metformin, the nucleoside reverse-transcriptase inhibitors and, rarely, linezolid. We report a case in which severe lactic acidosis developed as an adverse effect of linezolid in a 75-year-old woman who had been on linezolid for 30 days for treatment of a wound infection caused by methicillin-resistant coagulase-negative Staphylococcus. Discontinuation of linezolid and hemodialysis improved her lactic acidosis.
Keywords
Linezolid; Lactic acidosis;
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