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http://dx.doi.org/10.3904/kjm.2012.82.3.367

A Case of Lithium-Induced Nephrogenic Diabetes Insipidus and Rhabdomyolysis  

Moh, In-Ho (Department of Internal Medicine, Hallym Kidney Research Institute, Hallym University College of Medicine)
Lee, Young-Ki (Department of Internal Medicine, Hallym Kidney Research Institute, Hallym University College of Medicine)
Son, Seung-Yeon (Department of Internal Medicine, Hallym Kidney Research Institute, Hallym University College of Medicine)
Sin, Yun-Ho (Department of Internal Medicine, Hallym Kidney Research Institute, Hallym University College of Medicine)
Lee, Seung-Min (Department of Internal Medicine, Hallym Kidney Research Institute, Hallym University College of Medicine)
Lee, Dong-Hun (Department of Internal Medicine, Hallym Kidney Research Institute, Hallym University College of Medicine)
Noh, Jung-Woo (Department of Internal Medicine, Hallym Kidney Research Institute, Hallym University College of Medicine)
Publication Information
The Korean Journal of Medicine / v.82, no.3, 2012 , pp. 367-370 More about this Journal
Abstract
A 59-year-old woman was admitted to our hospital with polydipsia and general weakness. She had a 30-year history of bipolar disorder and was being treated with risperidone (4 mg/day) and lithium carbonate (1,200 mg/day). During her time in hospital, her urine output and serum osmolality increased, and her urine osmolality decreased. She was found to have myoglobulinuria, an elevated creatine kinase level, and abnormal renal function. Based on these findings, the patient was diagnosed with diabetes insipidus and rhabdomyolysis secondary to lithium therapy. After fluid therapy and the withdrawal of lithium, her clinical symptoms improved significantly. Her urine volume decreased gradually after treatment with amiloride. The effects of lithium on the muscle system are unknown. Hyperosmolarity caused by lithium-induced diabetes insipidus is considered a contributing factor in rhabdomyolysis.
Keywords
Lithium; Rhabdomyolysis; Nephrogenic diabetes insipidus;
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