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http://dx.doi.org/10.3904/kjm.2012.82.3.341

Protease Inhibitor Treatment of Disseminated Intravascular Coagulation Associated with Aortic Dissection  

Ko, Sung-Min (Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine)
Kim, Nam-Jun (Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine)
Kim, Chung-Hun (Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine)
Cho, Jin-Hyun (Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine)
Lee, Eun-Young (Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine)
Huh, Kyung-Min (Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine)
Kim, Duk-Kyung (Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine)
Publication Information
The Korean Journal of Medicine / v.82, no.3, 2012 , pp. 341-346 More about this Journal
Abstract
Disseminated intravascular coagulation (DIC) is a rare complication of aortic dissection. We report an unusual case of a 64-year-old woman with DIC associated with chronic aortic dissection who developed catastrophic intracranial hemorrhage. Computed tomography (CT) revealed partially thrombosed false lumen in the chronic dissected aneurysm of the thoracoabdominal aorta, which remained after surgery for acute type A aortic dissection. The laboratory profile showed features of DIC, including thrombocytopenia, hypofibrinogenemia, and increased D-dimer levels. Bleeding diathesis, including ecchymosis and coagulopathy, showed improvement following treatment with protease inhibitors (nafamostat and camostat).
Keywords
Aortic dissection; Disseminated intravascular coagulation; Protease inhibitor; Nafamostat mesilate; Heparin;
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