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http://dx.doi.org/10.3904/kjm.2012.82.2.241

A Case of Metformin-Induced Lactic Acidosis with Acute Kidney Injury Misdiagnosed as Hepatorenal Syndrome in a Cirrhosis Patient  

Kim, Ok-Ki (Department of Internal Medicine, Chonnam National University Medical School)
Oak, Chan-Young (Department of Internal Medicine, Chonnam National University Medical School)
Jeong, Ji-Min (Department of Internal Medicine, Chonnam National University Medical School)
Lee, Jeong-Won (Department of Internal Medicine, Chonnam National University Medical School)
Shin, Min-Ho (Department of Internal Medicine, Il-Gok Hospital)
Kim, Nam-Ho (Department of Internal Medicine, Chonnam National University Medical School)
Publication Information
The Korean Journal of Medicine / v.82, no.2, 2012 , pp. 241-246 More about this Journal
Abstract
Metformin is a well-established drug for the treatment of type 2 diabetes mellitus. The incidence of metformin-induced lactic acidosis is low, but the estimated mortality rate is approximately 50% in cases with lactic acidosis in combination with metformin therapy. Lactic acidosis occurs most often in patients with compromised cardiac, pulmonary, hepatic, and/or renal function. Acute kidney injury is a relatively frequent problem in cirrhosis patients. Hepatorenal syndrome is a diagnosis of exclusion, making its diagnosis difficult in the clinical field. We report a case of metformin-induced lactic acidosis with acute kidney injury that was misdiagnosed as hepatorenal syndrome in a cirrhosis patient.
Keywords
Metformin; Acidosis; Lactic; Liver Cirrhosis; Hepatorenal syndrome;
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