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A Case of Rheumatoid Arthritis Associated with Klinefelter's Syndrome  

Seo, Mi-Ryoung (Department of Internal Medicine, Division of Rheumatology, Gil Medical Center, Gachon University of Medicine and Science)
Cho, Hyun-Jung (Department of Internal Medicine, Division of Rheumatology, Gil Medical Center, Gachon University of Medicine and Science)
Choi, Hyo-Jin (Department of Internal Medicine, Division of Rheumatology, Gil Medical Center, Gachon University of Medicine and Science)
Baek, Han-Joo (Department of Internal Medicine, Division of Rheumatology, Gil Medical Center, Gachon University of Medicine and Science)
Ahn, Jeong-Yeal (Department of Laboratory Medicine, Gil Medical Center, Gachon University of Medicine and Science)
Publication Information
The Korean Journal of Medicine / v.81, no.3, 2011 , pp. 412-415 More about this Journal
Abstract
Klinefelter's syndrome is a disorder of sexual differentiation in males, characterized by the presence of two or more X-chromosomes, hypogonadism, and lack of secondary sexual characteristics. The association between Klinefelter's syndrome and systemic lupus erythematous has been described, while cases of rheumatoid arthritis associated with Klinefelter's syndrome are rare. We report the first Korean case: a 29-year-old man with Klinefelter's syndrome who developed rheumatoid arthritis. The sex hormone imbalance might have influenced the onset and course of his disease.
Keywords
Klinefelter's syndrome; Rheumatoid arthritis; Sex hormones;
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