Natural Course of Benign Pulmonary Metastasizing Leiomyoma

Benign metastasizing pulmonary leiomyoma is a rare disease that is usually detected several years after hysterectomy or myomectomy. Recently, we experienced two cases, one with monthly chest pain and the other without symptoms, which were diagnosed with benign metastasizing leiomyoma in the lung. A 48-year-old woman who underwent hysterectomy 12 years earlier was referred to us because of multiple pulmonary nodules on chest radiography, and chest pain for 6 months. Thoracoscopic tumor excision was performed. Pathologically, she was diagnosed with benign metastasizing leiomyoma in the lung. After that, chest computed tomography showed tumors with a progressive reduction in size. The other 48-year-old woman, who had undergone myomectomy for uterine leiomyoma 8 years before, visited our hospital for evaluation of incidentally revealed bilateral multiple nodules on chest radiography. The microscopic finding of percutaneous transthoracic needle biopsy revealed a benign pulmonary metastasizing leiomyoma originating from uterine leiomyoma. Multiple nodules on chest radiography were more increased than those performed 1 year and 3 months prior to admission. However, chest X-ray showed tumors that had progressively decreased in size at 6 months after diagnosis of menopause.

양성 전이성 폐 평활근종의 자연 경과

폐에 발생하는 양성 전이성 근종은 과거 자궁 절제술이나 근종 절제술을 시행 받은 가임기 여성에게 호발하는 드문 질환으로 악성의 임상 특징을 가진다. 대부분 무증상이나 일부에서는 마른 기침이나 흉통, 호흡곤란 및 심한 경우 호흡 부전까지 발생하는 등 여러 가지 임상양상을 가진다. 치료는 본 질환이 여성 호르몬과 관련 있어 여성 호르몬을 소실시키는 방법을 주로 사용하고 있다. 저자들은 자궁 절제술과 근종절제술을 시행받은 기왕력이 있는 여성에서 발생한 양성 전이성 폐평활근종 각각 1예를 경험하여 문헌고찰과 함께 보고하는 바이다.