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Late Adverse Reaction to Iodixanol ($Visipaque^{(R)}$)  

Kim, Cha-Young (Department of Internal Medicine, Gyeongsang National University Hospital)
Kim, Hee-Jin (Department of Internal Medicine, Gyeongsang National University Hospital)
Kim, Moon-Jin (Department of Internal Medicine, Gyeongsang National University Hospital)
Kang, Yeo-Jin (Department of Internal Medicine, Gyeongsang National University Hospital)
Kim, Hyun-Jung (Department of Internal Medicine, Gyeongsang National University Hospital)
Chang, Se-Ho (Department of Internal Medicine, Gyeongsang National University Hospital)
Park, Dong-Jun (Department of Internal Medicine, Gyeongsang National University Hospital)
Publication Information
The Korean Journal of Medicine / v.81, no.1, 2011 , pp. 130-134 More about this Journal
Abstract
Late adverse reactions to iodinated contrast medium are defined as reactions occurring 1 hour to 1 week after contrast medium injection. The majority of late adverse reactions are cutaneous reactions, and include itching, maculopapular rash, urticaria, erythematous patches, and angioedema. We report a patient with an iodixanol ($Visipaque^{(R)}$)-induced late adverse reaction. She was admitted for evaluation of nephrotic range proteinuria and edema. Abdomen and chest enhanced computed tomography was performed as a malignancy work-up. Sixteen hours after radiocontrast exposure, her entire body felt itchy. A maculopapular rash was first detected on her back and abdomen 24 hours after exposure, and spread over her entire body, including her face. Her skin lesions resolved completely in 5 days after administering steroid and antihistamine. We should consider late adverse reactions of iodinated contrast medium when we detect skin lesions late after radiocontrast use.
Keywords
Iodixanol; Hypersensitivity; Adverse reaction;
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