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A case of adrenocortical adenoma with primary hyperaldosteronism and subclinical Cushing's syndrome  

Hwang, Byung-Hee (Department of Internal Medicine, Bucheon St. Mary's Hospital, The Catholic University of Korea College of Medicine)
Yu, Ji-Youn (Department of Internal Medicine, Bucheon St. Mary's Hospital, The Catholic University of Korea College of Medicine)
Jung, Jin-Hwan (Department of Internal Medicine, Bucheon St. Mary's Hospital, The Catholic University of Korea College of Medicine)
Kim, Sung-Rae (Department of Internal Medicine, Bucheon St. Mary's Hospital, The Catholic University of Korea College of Medicine)
Yoo, Soon-Jib (Department of Internal Medicine, Bucheon St. Mary's Hospital, The Catholic University of Korea College of Medicine)
Kang, Sung-Koo (Department of Internal Medicine, Bucheon St. Mary's Hospital, The Catholic University of Korea College of Medicine)
Lee, Seong-Su (Department of Internal Medicine, Bucheon St. Mary's Hospital, The Catholic University of Korea College of Medicine)
Publication Information
The Korean Journal of Medicine / v.79, no.3, 2010 , pp. 321-326 More about this Journal
Abstract
Cases of combined primary hyperaldosteronism and subclinical Cushing's syndrome are extremely rare. We identified a left adrenocortical tumor in a 41-year-old woman by computed tomography (CT) during an evaluation for hypokalemia and hypertension. Hormonal assessment demonstrated normal aldosterone concentrations, low plasma renin activity, an increased aldosterone/renin ratio, and normal serum cortisol levels. Selective adrenal venous sampling for the determination of aldosterone concentrations showed an overfunctioning left adrenal gland. Dexamethasone (overnight 1mg, 2 mg, 8 mg) suppression tests showed insuppressible cortisol. We diagnosed the patient as having an aldosterone-producing adrenal adenoma associated with subclinical Cushing's syndrome.
Keywords
Adrenocortical adenoma; Cushing's syndrome; Hyperaldosteronism;
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