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http://dx.doi.org/10.4110/in.2015.15.3.121

Is CD137 Ligand (CD137L) Signaling a Fine Tuner of Immune Responses?  

Kwon, Byungsuk (School of Biological Sciences, University of Ulsan)
Publication Information
IMMUNE NETWORK / v.15, no.3, 2015 , pp. 121-124 More about this Journal
Abstract
Now, it has been being accepted that reverse signaling through CD137 ligand (CD137L) plays an important role in vivo during hematopoiesis and in immune regulation. However, due to technical difficulty in dissecting both directional signaling events simultaneously in vivo, most biological activities caused by CD137-CD137L interactions are considered as results from signaling events of the CD137 receptor. To make the story more complex, $CD137^{-/-}$ and $CD137L^{-/-}$ mice have increased or decreased immune responses in a context-dependent manner. In this Mini review, I will try to provide a plausible explanation for how CD137L signaling is controlled during immune responses.
Keywords
CD137 ligand; Immune regulation; Inflammation;
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