1 |
Banchereau, J., P. P. de, A. Valle, E. Garcia, and F. Rousset. 1991. Long-term human B cell lines dependent on interleukin-4 and antibody to CD40. Science 251: 70-72.
DOI
|
2 |
Arpin, C., J. Dechanet, K. C. Van, P. Merville, G. Grouard, F. Briere, J. Banchereau, and Y. J. Liu. 1995. Generation of memory B cells and plasma cells in vitro. Science 268: 720-722.
DOI
|
3 |
Johnston, R. J., A. C. Poholek, D. DiToro, I. Yusuf, D. Eto, B. Barnett, A. L. Dent, J. Craft, and S. Crotty. 2009. Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation. Science 325: 1006-1010.
DOI
|
4 |
Nurieva, R. I., Y. Chung, G. J. Martinez, X. O. Yang, S. Tanaka, T. D. Matskevitch, Y. H. Wang, and C. Dong. 2009. Bcl6 mediates the development of T follicular helper cells. Science 325: 1001-1005.
DOI
|
5 |
Yu, D., S. Rao, L. M. Tsai, S. K. Lee, Y. He, E. L. Sutcliffe, M. Srivastava, M. Linterman, L. Zheng, N. Simpson, J. I. Ellyard, I. A. Parish, C. S. Ma, Q. J. Li, C. R. Parish, C. R. Mackay, and C. G. Vinuesa. 2009. The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment. Immunity 31: 457-468.
DOI
|
6 |
Fillatreau, S., C. H. Sweenie, M. J. McGeachy, D. Gray, and S. M. Anderton. 2002. B cells regulate autoimmunity by provision of IL-10. Nat. Immunol. 3: 944-950.
|
7 |
Mizoguchi, A., E. Mizoguchi, H. Takedatsu, R. S. Blumberg, and A. K. Bhan. 2002. Chronic intestinal inflammatory condition generates IL-10-producing regulatory B cell subset characterized by CD1d upregulation. Immunity 16: 219-230.
DOI
ScienceOn
|
8 |
Mauri, C., D. Gray, N. Mushtaq, and M. Londei. 2003. Prevention of arthritis by interleukin 10-producing B cells. J. Exp. Med. 197: 489-501.
DOI
ScienceOn
|
9 |
Paul, W. E. and J. Ohara. 1987. B-cell stimulatory factor-1/interleukin 4. Annu. Rev. Immunol. 5: 429-459.
DOI
ScienceOn
|
10 |
Victora, G. D. and M. C. Nussenzweig. 2012. Germinal centers. Annu. Rev. Immunol. 30: 429-457.
DOI
|
11 |
MacLennan, I. C., K. M. Toellner, A. F. Cunningham, K. Serre, D. M. Sze, E. Zuniga, M. C. Cook, and C. G. Vinuesa. 2003. Extrafollicular antibody responses. Immunol. Rev. 194: 8-18.
DOI
|
12 |
King, I. L. and M. Mohrs. 2009. IL-4-producing T cells in reactive lymph nodes during helminth infection are T follicular helper cells. J. Exp. Med. 206: 1001-1007.
DOI
|
13 |
Vinuesa, C. G., M. A. Linterman, C. C. Goodnow, and K. L. Randall. 2010. T cells and follicular dendritic cells in germinal center B-cell formation and selection. Immunol. Rev. 237: 72-89.
DOI
|
14 |
Fazilleau, N., L. Mark, L. J. Heyzer-Williams, and M. G. Heyzer-Williams. 2009. Follicular helper T cells: lineage and location. Immunity 30: 324-335.
DOI
ScienceOn
|
15 |
Crotty, S. 2011. Follicular helper CD4 T cells (TFH). Annu. Rev. Immunol. 29: 621-663.
DOI
|
16 |
Nurieva, R. I., Y. Chung, D. Hwang, X. O. Yang, H. S. Kang, L. Ma, Y. H. Wang, S. S. Watowich, A. M. Jetten, Q. Tian, and C. Dong. 2008. Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages. Immunity 29: 138-149.
DOI
ScienceOn
|
17 |
Liu, X., X. Chen, B. Zhong, A. Wang, X. Wang, F. Chu, R. I. Nurieva, X. Yan, P. Chen, L. G. van der Flier, H. Nakatsukasa, S. S. Neelapu, W. Chen, H. Clevers, Q. Tian, H. Qi, L. Wei, and C. Dong. 2014. Transcription factor achaete-scute homologue 2 initiates follicular T-helper-cell development. Nature 507: 513-518.
DOI
|
18 |
Diehl, S. A., H. Schmidlin, M. Nagasawa, B. Blom, and H. Spits. 2012. IL-6 triggers IL-21 production by human T cells to drive STAT3-dependent plasma cell differentiation in B cells. Immunol. Cell Biol. 90: 802-811.
DOI
|
19 |
Eddahri, F., S. Denanglaire, F. Bureau, R. Spolski, W. J. Leonard, O. Leo, and F. Andris. 2009. Interleukin-6/STAT3 signaling regulates the ability of naive T cells to acquire B-cell help capacities. Blood 113: 2426-2433.
DOI
|
20 |
Ma, C. S., D. T. Avery, A. Chan, M. Batten, J. Bustamante, S. Boisson-Dupuis, P. D. Arkwright, A. Y. Kreins, D. Averbuch, D. Engelhard, K. Magdorf, S. S. Kilic, Y. Minegishi, S. Nonoyama, M. A. French, S. Choo, J. M. Smart, J. Peake, M. Wong, P. Gray, M. C. Cook, D. A. Fulcher, J. L. Casanova, E. K. Deenick, and S. G. Tangye. 2012. Functional STAT3 deficiency compromises the generation of human T follicular helper cells. Blood 119: 3997-4008.
DOI
|
21 |
Betz, B. C., K. L. Jordan-Williams, C. Wang, S. G. Kang, J. Liao, M. R. Logan, C. H. Kim, and E. J. Taparowsky. 2010. Batf coordinates multiple aspects of B and T cell function required for normal antibody responses. J. Exp. Med. 207: 933-942.
DOI
|
22 |
Ise, W., M. Kohyama, B. U. Schraml, T. Zhang, B. Schwer, U. Basu, F. W. Alt, J. Tang, E. M. Oltz, T. L. Murphy, and K. M. Murphy. 2011. The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells. Nat. Immunol. 12: 536-543.
DOI
|
23 |
Bollig, N., A. Brustle, K. Kellner, W. Ackermann, E. Abass, H. Raifer, B. Camara, C. Brendel, G. Giel, E. Bothur, M. Huber, C. Paul, A. Elli, R. A. Kroczek, R. Nurieva, C. Dong, R. Jacob, T. W. Mak, and M. Lohoff. 2012. Transcription factor IRF4 determines germinal center formation through follicular T-helper cell differentiation. Proc. Natl. Acad. Sci. U. S. A. 109: 8664-8669.
DOI
|
24 |
Baumjohann, D., R. Kageyama, J. M. Clingan, M. M. Morar, S. Patel, K. D. de, O. Bannard, J. A. Bluestone, M. Matloubian, K. M. Ansel, and L. T. Jeker. 2013. The microRNA cluster miR-17 approximately 92 promotes TFH cell differentiation and represses subset-inappropriate gene expression. Nat. Immunol. 14: 840-848.
DOI
|
25 |
Kang, S. G., W. H. Liu, P. Lu, H. Y. Jin, H. W. Lim, J. Shepherd, D. Fremgen, E. Verdin, M. B. Oldstone, H. Qi, J. R. Teijaro, and C. Xiao. 2013. MicroRNAs of the miR-17 approximately 92 family are critical regulators of T(FH) differentiation. Nat. Immunol. 14: 849-857.
DOI
|
26 |
Ballesteros-Tato, A., B. Leon, B. A. Graf, A. Moquin, P. S. Adams, F. E. Lund, and T. D. Randall. 2012. Interleukin-2 inhibits germinal center formation by limiting T follicular helper cell differentiation. Immunity 36: 847-856.
DOI
|
27 |
Eto, D., C. Lao, D. DiToro, B. Barnett, T. C. Escobar, R. Kageyama, I. Yusuf, and S. Crotty. 2011. IL-21 and IL-6 are critical for different aspects of B cell immunity and redundantly induce optimal follicular helper CD4 T cell (Tfh) differentiation. PLoS One 6: e17739.
DOI
|
28 |
Nakayamada, S., Y. Kanno, H. Takahashi, D. Jankovic, K. T. Lu, T. A. Johnson, H. W. Sun, G. Vahedi, O. Hakim, R. Handon, P. L. Schwartzberg, G. L. Hager, and J. J. O'Shea. 2011. Early Th1 cell differentiation is marked by a Tfh cell-like transition. Immunity 35: 919-931.
DOI
ScienceOn
|
29 |
Schmitt, N., R. Morita, L. Bourdery, S. E. Bentebibel, S. M. Zurawski, J. Banchereau, and H. Ueno. 2009. Human dendritic cells induce the differentiation of interleukin-21-producing T follicular helper-like cells through interleukin-12. Immunity 31: 158-169.
DOI
|
30 |
Johnston, R. J., Y. S. Choi, J. A. Diamond, J. A. Yang, and S. Crotty. 2012. STAT5 is a potent negative regulator of TFH cell differentiation. J. Exp. Med. 209: 243-250.
DOI
|
31 |
Sakaguchi, S., N. Sakaguchi, M. Asano, M. Itoh, and M. Toda. 1995. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 155: 1151-1164.
|
32 |
Sakaguchi, S., T. Yamaguchi, T. Nomura, and M. Ono. 2008. Regulatory T cells and immune tolerance. Cell 133: 775-787.
DOI
ScienceOn
|
33 |
Chaudhry, A., D. Rudra, P. Treuting, R. M. Samstein, Y. Liang, A. Kas, and A. Y. Rudensky. 2009. regulatory T cells control TH17 responses in a Stat3-dependent manner. Science 326: 986-991.
DOI
|
34 |
Zheng, Y., A. Chaudhry, A. Kas, P. deRoos, J. M. Kim, T. T. Chu, L. Corcoran, P. Treuting, U. Klein, and A. Y. Rudensky. 2009. Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses. Nature 458: 351-356.
DOI
|
35 |
Chung, Y., S. Tanaka, F. Chu, R. I. Nurieva, G. J. Martinez, S. Rawal, Y. H. Wang, H. Lim, J. M. Reynolds, X. H. Zhou, H. M. Fan, Z. M. Liu, S. S. Neelapu, and C. Dong. 2011. Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions. Nat. Med. 17: 983-988.
DOI
|
36 |
Koch, M. A., G. Tucker-Heard, N. R. Perdue, J. R. Killebrew, K. B. Urdahl, and D. J. Campbell. 2009. The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation. Nat. Immunol. 10: 595-602.
DOI
|
37 |
Linterman, M. A., W. Pierson, S. K. Lee, A. Kallies, S. Kawamoto, T. F. Rayner, M. Srivastava, D. P. Divekar, L. Beaton, J. J. Hogan, S. Fagarasan, A. Liston, K. G. Smith, and C. G. Vinuesa. 2011. follicular regulatory T cells control the germinal center response. Nat. Med. 17: 975-982.
DOI
ScienceOn
|
38 |
Vinuesa, C. G., I. Sanz, and M. C. Cook. 2009. Dysregulation of germinal centres in autoimmune disease. Nat. Rev. Immunol. 9: 845-857.
DOI
|
39 |
Lim, H. W., P. Hillsamer, and C. H. Kim. 2004. Regulatory T cells can migrate to follicles upon T cell activation and suppress GC-Th cells and GC-Th cell-driven B cell responses. J. Clin. Invest. 114: 1640-1649.
DOI
|
40 |
Neumann, C., F. Heinrich, K. Neumann, V. Junghans, M. F. Mashreghi, J. Ahlers, M. Janke, C. Rudolph, N. Mockel-Tenbrinck, A. A. Kuhl, M. M. Heimesaat, C. Esser, S. H. Im, A. Radbruch, S. Rutz, and A. Scheffold. 2014. Role of Blimp-1 in programing Th effector cells into IL-10 producers. J. Exp. Med. 211: 1807-1819
DOI
|
41 |
Choi, Y. S., J. A. Yang, and S. Crotty. 2013. Dynamic regulation of Bcl6 in follicular helper CD4 T (Tfh) cells. Curr. Opin. Immunol. 25: 366-372.
DOI
|
42 |
Sun, J., H. Dodd, E. K. Moser, R. Sharma, and T. J. Braciale. 2011. T cell help and innate-derived IL-27 induce Blimp-1-dependent IL-10 production by antiviral CTLs. Nat. Immunol. 12: 327-334.
DOI
|
43 |
Sage, P. T., L. M. Francisco, C. V. Carman, and A. H. Sharpe. 2013. The receptor PD-1 controls follicular regulatory T cells in the lymph nodes and blood. Nat. Immunol. 14: 152-161.
|
44 |
Choi, Y. S., R. Kageyama, D. Eto, T. C. Escobar, R. J. Johnston, L. Monticelli, C. Lao, and S. Crotty. 2011. ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6. Immunity 34: 932-946.
DOI
|
45 |
Hildebrand, J. M., Z. Yi, C. M. Buchta, J. Poovassery, L. L. Stunz, and G. A. Bishop. 2011. Roles of tumor necrosis factor receptor associated factor 3 (TRAF3) and TRAF5 in immune cell functions. Immunol. Rev. 244: 55-74.
DOI
|
46 |
Xie, P., Z. J. Kraus, L. L. Stunz, Y. Liu, and G. A. Bishop. 2011. TNF receptor-associated factor 3 is required for T cell-mediated immunity and TCR/CD28 signaling. J. Immunol. 186: 143-155.
DOI
|
47 |
Chang, J. H., H. Hu, J. Jin, N. Puebla-Osorio, Y. Xiao, B. E. Gilbert, R. Brink, S. E. Ullrich, and S. C. Sun. 2014. TRAF3 regulates the effector function of regulatory T cells and humoral immune responses. J. Exp. Med. 211: 137-151.
DOI
|
48 |
Tan, A. H., S. C. Wong, and K. P. Lam. 2006. Regulation of mouse inducible costimulator (ICOS) expression by Fyn-NFATc2 and ERK signaling in T cells. J. Biol. Chem. 281: 28666-28678.
DOI
|
49 |
Shevach, E. M. 2009. Mechanisms of T regulatory cell-mediated suppression. Immunity 30: 636-645.
DOI
ScienceOn
|
50 |
Wing, K., Y. Onishi, P. Prieto-Martin, T. Yamaguchi, M. Miyara, Z. Fehervari, T. Nomura, and S. Sakaguchi. 2008. CTLA-4 control over regulatory T cell function. Science 322: 271-275.
DOI
ScienceOn
|
51 |
Okazaki, T. and T. Honjo. 2006. The PD-1-PD-L pathway in immunological tolerance. Trends Immunol. 27: 195-201.
DOI
ScienceOn
|
52 |
Linterman, M. A., W. Pierson, S. K. Lee, A. Kallies, S. Kawamoto, T. F. Rayner, M. Srivastava, D. P. Divekar, L. Beaton, J. J. Hogan, S. Fagarasan, A. Liston, K. G. Smith, and C. G. Vinuesa. 2011. follicular regulatory T cells control the germinal center response. Nat. Med. 17: 975-982.
DOI
ScienceOn
|
53 |
Okazaki, T., Y. Tanaka, R. Nishio, T. Mitsuiye, A. Mizoguchi, J. Wang, M. Ishida, H. Hiai, A. Matsumori, N. Minato, and T. Honjo. 2003. Autoantibodies against cardiac troponin I are responsible for dilated cardiomyopathy in PD-1-deficient mice. Nat. Med. 9: 1477-1483.
DOI
|
54 |
Okazaki, T., Y. Otaka, J. Wang, H. Hiai, T. Takai, J. V. Ravetch, and T. Honjo. 2005. Hydronephrosis associated with antiurothelial and antinuclear autoantibodies in BALB/c-Fcgr2b-/-Pdcd1-/- mice. J. Exp. Med. 202: 1643-1648.
DOI
|
55 |
Good-Jacobson, K. L., C. G. Szumilas, L. Chen, A. H. Sharpe, M. M. Tomayko, and M. J. Shlomchik. 2010. PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells. Nat. Immunol. 11: 535-542.
DOI
|
56 |
Jeannin, P., S. Lecoanet, Y. Delneste, J. F. Gauchat, and J. Y. Bonnefoy. 1998. IgE versus IgG4 production can be differentially regulated by IL-10. J. Immunol. 160: 3555-3561.
|
57 |
Coffman, R. L., D. A. Lebman, and B. Shrader. 1989. Transforming growth factor beta specifically enhances IgA production by lipopolysaccharide-stimulated murine B lymphocytes. J. Exp. Med. 170: 1039-1044.
DOI
ScienceOn
|
58 |
Lu, L., H. J. Kim, M. B. Werneck, and H. Cantor. 2008. Regulation of regulatory T cells: Interruption of the NKG2A-Qa-1 interaction allows robust suppressive activity and resolution of autoimmune disease. Proc. Natl. Acad. Sci. U. S. A. 105: 19420-19425.
DOI
|
59 |
Sarantopoulos, S., L. Lu, and H. Cantor. 2004. Qa-1 restriction of suppressor T cells. J. Clin. Invest. 114: 1218-1221.
DOI
|
60 |
Hu, D., K. Ikizawa, L. Lu, M. E. Sanchirico, M. L. Shinohara, and H. Cantor. 2004. Analysis of regulatory CD8 T cells in Qa-1-deficient mice. Nat. Immunol. 5: 516-523.
DOI
|
61 |
Cantor, H. and E. A. Boyse. 1975. Functional subclasses of T-lymphocytes bearing different Ly antigens. I. The generation of functionally distinct T-cell subclasses is a differentiative process independent of antigen. J. Exp. Med. 141: 1376-1389.
DOI
|
62 |
Cantor, H., F. W. Shen, and E. A. Boyse. 1976. Separation of helper T cells from suppressor T cells expressing different Ly components. II. Activation by antigen: after immunization, antigen-specific suppressor and helper activities are mediated by distinct T-cell subclasses. J. Exp. Med. 143: 1391-1340.
DOI
ScienceOn
|
63 |
Kim, H. J., B. Verbinnen, X. Tang, L. Lu, and H. Cantor. 2010. Inhibition of follicular T-helper cells by CD8(+) regulatory T cells is essential for self tolerance. Nature 467: 328-332.
DOI
|
64 |
Kim, H. J. and H. Cantor. 2011. Regulation of self-tolerance by Qa-1-restricted CD8(+) regulatory T cells. Semin. Immunol. 23: 446-452.
DOI
|
65 |
Leavenworth, J. W., X. Tang, H. J. Kim, X. Wang, and H. Cantor. 2013. Amelioration of arthritis through mobilization of peptide-specific regulatory T cells. J. Clin. Invest. 123: 1382-1389.
DOI
|
66 |
de Kouchkovsky, D., J. H. Esensten, W. L. Rosenthal, M. M. Morar, J. A. Bluestone, and L. T. Jeker. 2013. microRNA-17-92 regulates IL-10 production by regulatory T cells and control of experimental autoimmune encephalomyelitis. J. Immunol. 191: 1594-1605.
DOI
|
67 |
Jiang, H., S. M. Canfield, M. P. Gallagher, H. H. Jiang, Y. Jiang, Z. Zheng, and L. Chess. 2010. HLA-E-restricted regulatory CD8(+) T cells are involved in development and control of human autoimmune type 1 diabetes. J. Clin. Invest. 120: 3641-3650.
DOI
|
68 |
Correale, J. and A. Villa. 2008. Isolation and characterization of regulatory T cells in multiple sclerosis. J. Neuroimmunol. 195: 121-134.
DOI
|
69 |
Lu, L. F., M. P. Boldin, A. Chaudhry, L. L. Lin, K. D. Taganov, T. Hanada, A. Yoshimura, D. Baltimore, and A. Y. Rudensky. 2010. Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responses. Cell 142: 914-929.
DOI
ScienceOn
|
70 |
Craft, J. E. 2012. Follicular helper T cells in immunity and systemic autoimmunity. Nat. Rev. Rheumatol. 8: 337-347.
DOI
|
71 |
Biswas, P. S., S. Gupta, R. A. Stirzaker, V. Kumar, R. Jessberger, T. T. Lu, G. Bhagat, and A. B. Pernis. 2012. Dual regulation of IRF4 function in T and B cells is required for the coordination of T-B cell interactions and the prevention of autoimmunity. J. Exp. Med. 209: 581-596.
DOI
|
72 |
Dienz, O., S. M. Eaton, J. P. Bond, W. Neveu, D. Moquin, R. Noubade, E. M. Briso, C. Charland, W. J. Leonard, G. Ciliberto, C. Teuscher, L. Haynes, and M. Rincon. 2009. The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by T cells. J. Exp. Med. 206: 69-78.
DOI
|
73 |
Lu, L. F., T. H. Thai, D. P. Calado, A. Chaudhry, M. Kubo, K. Tanaka, G. B. Loeb, H. Lee, A. Yoshimura, K. Rajewsky, and A. Y. Rudensky. 2009. Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells by targeting SOCS1 protein. Immunity 30: 80-91.
DOI
ScienceOn
|
74 |
Watanabe, M., S. Nakajima, K. Ohnuki, S. Ogawa, M. Yamashita, T. Nakayama, Y. Murakami, K. Tanabe, and R. Abe. 2012. AP-1 is involved in ICOS gene expression downstream of TCR/CD28 and cytokine receptor signaling. Eur. J. Immunol. 42: 1850-1862.
DOI
|
75 |
Lu, L., K. Ikizawa, D. Hu, M. B. Werneck, K. W. Wucherpfennig, and H. Cantor. 2007. Regulation of activated T cells by NK cells via the Qa-1-NKG2A inhibitory pathway. Immunity 26: 593-604.
DOI
|
76 |
Nakamura, K., A. Kitani, and W. Strober. 2001. Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta. J. Exp. Med. 194: 629-644.
DOI
ScienceOn
|
77 |
Kim, H. J., X. Wang, S. Radfar, T. J. Sproule, D. C. Roopenian, and H. Cantor. 2011. T regulatory cells express the Ly49 Class I MHC receptor and are defective in autoimmune prone B6-Yaa mice. Proc. Natl. Acad. Sci. U. S. A 108: 2010-2015.
DOI
|
78 |
Wahren-Herlenius, M. and T. Dorner. 2013. Immunopathogenic mechanisms of systemic autoimmune disease. Lancet 382: 819-831.
DOI
|
79 |
Lim, H. W., P. Hillsamer, A. H. Banham, and C. H. Kim. 2005. Cutting edge: direct suppression of B cells by regulatory T cells. J. Immunol. 175: 4180-4183.
DOI
|