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http://dx.doi.org/10.4110/in.2014.14.4.171

The Roles of Innate Lymphoid Cells in the Development of Asthma  

Woo, Yeonduk (Laboratory of Immune Regulation, Department of Biomedical Sciences, Seoul National University College of Medicine)
Jeong, Dongjin (Laboratory of Immune Regulation, Department of Biomedical Sciences, Seoul National University College of Medicine)
Chung, Doo Hyun (Laboratory of Immune Regulation, Department of Biomedical Sciences, Seoul National University College of Medicine)
Kim, Hye Young (Department of Medical Science, Seoul National University College of Medicine and Hospital)
Publication Information
IMMUNE NETWORK / v.14, no.4, 2014 , pp. 171-181 More about this Journal
Abstract
Asthma is a common pulmonary disease with several different forms. The most studied form of asthma is the allergic form, which is mainly related to the function of Th2 cells and their production of cytokines (IL-4, IL-5, and IL-13) in association with allergen sensitization and adaptive immunity. Recently, there have been many advances in understanding non-allergic asthma, which seems to be related to environmental factors such as air pollution, infection, or even obesity. Cells of the innate immune system, including macrophages, neutrophils, and natural killer T cells as well as the newly described innate lymphoid cells, are effective producers of a variety of cytokines and seem to play important roles in the development of non-allergic asthma. In this review, we focus on recent findings regarding innate lymphoid cells and their roles in asthma.
Keywords
Airway hyperreactivity; Asthma; Innate lymphoid cells; Allergic asthma; Non-allergic asthma;
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