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http://dx.doi.org/10.4110/in.2011.11.5.288

Role of Salvia miltiorrhiza for Modulation of Th2-derived Cytokines in the Resolution of Inflammation  

Moon, Sun-Hee (College of Pharmacy, Sahmyook University)
Shin, Seul-Mee (College of Pharmacy, Sahmyook University)
Kim, Seul-Ah (College of Pharmacy, Sahmyook University)
Oh, Hee-Eun (College of Pharmacy, Sahmyook University)
Han, Shin-Ha (College of Pharmacy, Sahmyook University)
Lee, Seung-Jeong (College of Pharmacy, Chungbuk National University)
Kim, Kyung-Jae (College of Pharmacy, Sahmyook University)
Publication Information
IMMUNE NETWORK / v.11, no.5, 2011 , pp. 288-298 More about this Journal
Abstract
Background: Salvia miltiorrhiza (SM) has been used to treat inflammatory diseases including edema and arthritis; however, the anti-inflammatory mechanism of SM action remains unresolved. Methods: The effects of an ethanol extract of SM (ESM) on pro-inflammatory cytokines such as TNF-${\alpha}$, IL-$1{\beta}$, IL-6, and NO, and on anti-inflammatory cytokines including IL-4, IL-10, TGF-${\beta}$, and IL-1Ra have been studied in an attempt to elucidate the anti-inflammatory mechanism in murine macrophages. Results: ESM inhibited the production of pro-inflammatory cytokines via down-regulation of gene and protein expression whereas it increased the anti-inflammatory cytokines. Furthermore, ESM inhibited the expression of the chemokines, RANTES and CX3CL1, as well as of inflammatory mediators such as TLR-4 and $11{\beta}$-HSD1. Conclusion: These results indicated that the regulatory effects of ESM may be mediated though the suppression of pro-inflammatory cytokines as well as the induction of anti-inflammatory cytokines. Consequently, we speculate that ESM has therapeutic potential for inflammation-associated disorders.
Keywords
Salvia miltiorrhiza; Pro-inflammatory cytokines; Chemokine; Th2 cytokine;
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Times Cited By KSCI : 1  (Citation Analysis)
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