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http://dx.doi.org/10.4110/in.2011.11.5.253

Vitamin D Receptor Gene TaqI, BsmI and FokI Polymorphisms in Korean Patients with Tuberculosis  

Kang, Tae-Jin (Institute of Chronic Disease, College of Pharmacy, Sahmyook University)
Jin, Song-Hou (Institute of Hansen's Disease, College of Medicine, The Catholic University of Korea)
Yeum, Chung-Eun (Institute of Hansen's Disease, College of Medicine, The Catholic University of Korea)
Lee, Seong-Beom (Institute of Hansen's Disease, College of Medicine, The Catholic University of Korea)
Kim, Chi-Hong (Department of Internal Medicine, College of Medicine, The Catholic University of Korea)
Lee, Sang-Haak (Department of Internal Medicine, College of Medicine, The Catholic University of Korea)
Kim, Kwan-Hyoung (Department of Internal Medicine, College of Medicine, The Catholic University of Korea)
Shin, Eun-Soon (DNA Link Inc.)
Chae, Gue-Tae (Institute of Hansen's Disease, College of Medicine, The Catholic University of Korea)
Publication Information
IMMUNE NETWORK / v.11, no.5, 2011 , pp. 253-257 More about this Journal
Abstract
Background: The active metabolite (1, 25- dihydroxycholecalciferol) of vitamin D (25-hydroxycholecalciferol) leads to activation of macrophages and deficiency of vitamin D seems to be involved in the risk of tuberculosis. The effects of vitamin D are exerted by interaction with the vitamin D receptor (VDR) and may be influenced by polymorphism in the VDR gene. In this study, variation in the VDR gene was investigated in Korean population with tuberculosis. Methods: We typed three VDR polymorphisms of restriction endonuclease sites for TaqI, BsmI and FokI in 155 patients with tuberculosis and 105 healthy volunteers. Results: The frequencies of FokI genotypes determined from TB patients were 29.13% for FF, 56.31% for Ff, and 14.56% for ff. We observed 1.4-fold increased prevalence of the Ff genotype in TB patients compared with normal healthy groups (p=0.0857). However, there was no significant association between the genotype groups, TB patient and normal control, for FokI polymorphism. There was also no significant association between VDR gene and tuberculosis in another polymorphism (BsmI and TaqI). Conclusion: Three polymorphisms (TaqI, BsmI and FokI) in the VDR gene do not appear to be responsible for host susceptibility to human tuberculosis in Korean population.
Keywords
VDR; Polymorphism; Tuberculosis; Korean; FokI;
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1 Rook GA, Steele J, Fraher L, Barker S, Karmali R, O'Riordan J, Stanford J: Vitamin D3, gamma interferon, and control of proliferation of Mycobacterium tuberculosis by human monocytes. Immunology 57;159-163, 1986.
2 Wilkinson RJ, Llewelyn M, Toossi Z, Patel P, Pasvol G, Lalvani A, Wright D, Latif M, Davidson RN: Influence of vitamin D deficiency and vitamin D receptor polymorphisms on tuberculosis among Gujarati Asians in west London: a case-control study. Lancet 355;618-621, 2000.   DOI   ScienceOn
3 Liu PT, Stenger S, Li H, Wenzel L, Tan BH, Krutzik SR, Ochoa MT, Schauber J, Wu K, Meinken C, Kamen DL, Wagner M, Bals R, Steinmeyer A, ZUgel U, Gallo RL, Eisenberg D, Hewison M, Hollis BW, Adams JS, Bloom BR, Modlin RL: Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science 311; 1770-1773, 2006.   DOI   ScienceOn
4 Vidyarani M, Selvaraj P, Jawahar MS, Narayanan PR: 1, 25 Dihydroxyvitamin D3 modulated cytokine response in pulmonary tuberculosis. Cytokine 40;128-134, 2007.   DOI   ScienceOn
5 Schauf V, Ryan S, Scollard D, Jonasson O, Brown A, Nelson K, Smith T, Vithayasai V. Leprosy associated with HLA-DR2 and DQw1 in the population of northern Thailand. Tissue Antigens 26;243-247, 1985.
6 Bellamy R, Ruwende C, Corrah T, McAdam KP, Thursz M, Whittle HC, Hill AV: Tuberculosis and chronic hepatitis B virus infection in Africans and variation in the vitamin D receptor gene. J Infect Dis 179;721-724, 1999.   DOI   ScienceOn
7 Roy S, Frodsham A, Saha B, Hazra SK, Mascie-Taylor CG, Hill AV: Association of vitamin D receptor genotype with leprosy type. J Infect Dis 179;187-191, 1999.   DOI   ScienceOn
8 Lucotte G, Mercier G, Burckel A: Fok I polymorphism at the human vitamin D receptor gene locus in Europeans and Africans. Clin Genet 55;281-282, 1999.   DOI   ScienceOn
9 Delgado JC, Baena A, Thim S, Goldfeld AE: Ethnic-specific genetic associations with pulmonary tuberculosis. J Infect Dis 186;1463-1468, 2002.   DOI   ScienceOn
10 Kim SJ, Choi IH, Dahlberg S, Nisperos B, Kim JD, Hansen JA: HLA and leprosy in Koreans. Tissue Antigens 29;146-153, 1987.
11 Bellamy R, Ruwende C, Corrah T, McAdam KP, Whittle HC, Hill AV. Variations in the NRAMP1 gene and susceptibility to tuberculosis in West Africans. N Engl J Med 338;640-644, 1998.   DOI   ScienceOn
12 Rani R, Fernandez-Vina MA, Zaheer SA, Beena KR, Stastny P: Study of HLA class II alleles by PCR oligotyping in leprosy patients from north India. Tissue Antigens 42;133-137, 1993.   DOI   ScienceOn
13 Singh SP, Mehra NK, Dingley HB, Pande JN, Vaidya MC: Human leukocyte antigen (HLA)-linked control of susceptibility to pulmonary tuberculosis and association with HLA-DR types. J Infect Dis 148;676-681, 1983.   DOI   ScienceOn
14 Haussler MR, Whitfield GK, Haussler CA, Hsieh JC, Thompson PD, Selznick SH, Dominguez CE, Jurutka PW: The nuclear vitamin D receptor: biological and molecular regulatory properties revealed. J Bone Miner Res 13;325-349, 1998.   DOI   ScienceOn
15 Abel L, SAnchez FO, Oberti J, Thuc NV, Hoa LV, Lap VD, Skamene E, Lagrange PH, Schurr E: Susceptibility to leprosy is linked to the human NRAMP1 gene. J Infect Dis 177;133-145, 1998.   DOI   ScienceOn
16 Deluca HF, Cantorna MT. Vitamin D: its role and uses in immunology. FASEB J 15;2579-2585, 2001.   DOI
17 Rigby WF: The immunobiology of vitamin D. Immunol Today 9;54-58, 1988.   DOI   ScienceOn
18 Wang LM, Kimura A, Satoh M, Mineshita S: HLA linked with leprosy in southern China: HLA-linked resistance alleles to leprosy. Int J Lepr Other Mycobact Dis 67;403-408, 1999.
19 Dorman SE, Holland SM: Mutation in the signal-transducing chain of the interferon-gamma receptor and susceptibility to mycobacterial infection. J Clin Invest 101;2364-2369, 1998.   DOI   ScienceOn
20 Altare F, Durandy A, Lammas D, Emile JF, Lamhamedi S, Le Deist F, Drysdale P, Jouanguy E, Doffinger R, Bernaudin F, Jeppsson O, Gollob JA, Meinl E, Segal AW, Fischer A, Kumararatne D, Casanova JL: Impairment of mycobacterial immunity in human interleukin-12 receptor deficiency. Science 280;1432-1435, 1998.   DOI